← Cofactor catalogue
Coenzyme
coenzyme M
CofactorMech:coenzyme-m · CHEBI:17905
coenzyme M is represented by the precise ChEBI entity CHEBI:17905. Cofactor roles are chemical-context annotations; ingredient links describe chemical supply and do not establish uptake, bioavailability or a requirement for every organism.
Download source YAML · View source at this revision
Chemical identity evidence
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ChEBI CHEBI:17905 — ChEBI assigns a cofactor, coenzyme or prosthetic-group role to CHEBI:17905.
Source reference · JSON Pointer /roles_classification · Source licence: CC-BY-4.0
Scoped relationships
Provisional links retain upstream ingredient identifiers. Verified links describe the cited source context, not universal organism requirements. Conjugate forms and precursor supply are distinct relationships.
Supplied by · CHEBI:17905
PROVISIONAL · mediaingredientmech
The current MIM ontology mapping exactly matches the candidate cofactor chemical identifier. This establishes a compound supply link, not organism-specific uptake or requirement.
Linked source record: data/ingredients/mapped/2-mercaptoethanesulfonate.yaml
Source revision: 0529fc6bc065bfa04aba0aed234f6b0cfad6a142
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MIM ingredient identity — The cited ingredient is mapped to CHEBI:17905; this is a compound-identity assertion, not a bioavailability measurement.
Source reference · JSON Pointer /identifier · Source licence: CC-BY-4.0
Required by · proteintraitsmech:COFACTOR_REQ_CHEBI_17905
VERIFIED · proteintraitsmech
Conceptual requirement coverage: this PTM trait defines the requirement for the same ChEBI chemical. It is not an organism-level or enzyme-level measurement.
Linked source record: data/traits/function/cofactor_requirement/chebi/coenzyme-m-chebi17905.yaml
Source revision: 8d08b33cfbee1e9d1c2fdb2211b82b49dd0c8b1f
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PTM cofactor-requirement concept — The target is a CLASS trait with an explicit cross-reference to this chemical, rather than a measured protein observation.
Source reference · JSON Pointer /xrefs · Source licence: CC-BY-4.0
Used by · MetaCyc:METHANOGENESIS-PWY
VERIFIED · pathwaymech
PathwayMech edge native-ne036 records MetaCyc:CoM consumes MetaCyc:2.1.1.86-RXN. This is a cross-reference to the source-scoped reaction or cofactor annotation, not proof of complete pathway flux. ChEBI explicitly cross-references MetaCyc:CoM. The native route ends at methyl-CoM; it does not itself include methane formation.
Linked source record: data/pathways/methanogenesis-from-h2-and-co2.yaml
Source revision: 9584009d49579267233124f4a1057b9425a007d9
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PathwayMech reaction or cofactor edge — PathwayMech edge native-ne036 records MetaCyc:CoM consumes MetaCyc:2.1.1.86-RXN. This is a cross-reference to the source-scoped reaction or cofactor annotation, not proof of complete pathway flux. ChEBI explicitly cross-references MetaCyc:CoM. The native route ends at methyl-CoM; it does not itself include methane formation.
Source reference · JSON Pointer /mechanistic_edges/35 · Source licence: CC-BY-4.0
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ChEBI CHEBI:17905 — The issuing ChEBI record cross-references the native MetaCyc identifier CoM.
Source reference · JSON Pointer /database_accessions · Source licence: CC-BY-4.0
Research gaps
- proteintraitsmech: The curated PTM link covers a cofactor-requirement concept only. A separately sourced, named enzyme exemplar requiring this exact chemical has not been curated in this seed record.