Prosthetic group

FAD

CofactorMech:fad · CHEBI:16238

FAD is represented by the precise ChEBI entity CHEBI:16238. Cofactor roles are chemical-context annotations; ingredient links describe chemical supply and do not establish uptake, bioavailability or a requirement for every organism.

Download source YAML · View source at this revision

Chemical identity evidence

ChEBI CHEBI:16238 — ChEBI assigns a cofactor, coenzyme or prosthetic-group role to CHEBI:16238.

Source reference · JSON Pointer /roles_classification · Source licence: CC-BY-4.0

Scoped relationships

Provisional links retain upstream ingredient identifiers. Verified links describe the cited source context, not universal organism requirements. Conjugate forms and precursor supply are distinct relationships.

Supplied by · CHEBI:16238

PROVISIONAL · mediaingredientmech

The current MIM ontology mapping exactly matches the candidate cofactor chemical identifier. This establishes a compound supply link, not organism-specific uptake or requirement.

Linked source record: data/ingredients/mapped/Fad.yaml
Source revision: 0529fc6bc065bfa04aba0aed234f6b0cfad6a142

MIM ingredient identity — The cited ingredient is mapped to CHEBI:16238; this is a compound-identity assertion, not a bioavailability measurement.

Source reference · JSON Pointer /identifier · Source licence: CC-BY-4.0

Required by · proteintraitsmech:COFACTOR_REQ_CHEBI_16238

VERIFIED · proteintraitsmech

Conceptual requirement coverage: this PTM trait defines the requirement for the same ChEBI chemical. It is not an organism-level or enzyme-level measurement.

Linked source record: data/traits/function/cofactor_requirement/chebi/fad-chebi16238.yaml
Source revision: 8d08b33cfbee1e9d1c2fdb2211b82b49dd0c8b1f

PTM cofactor-requirement concept — The target is a CLASS trait with an explicit cross-reference to this chemical, rather than a measured protein observation.

Source reference · JSON Pointer /xrefs · Source licence: CC-BY-4.0

Conjugate form produced by · MetaCyc:RIBOSYN2-PWY

VERIFIED · pathwaymech

PathwayMech edge edge-044 records RHEA:17238 produces CHEBI:57692. This is a cross-reference to the source-scoped reaction or cofactor annotation, not proof of complete pathway flux. The pathway chemical is CHEBI:57692, a distinct conjugate form of CHEBI:16238; this link does not identify their charge states.

Target chemical: CHEBI:57692

Linked source record: data/pathways/flavin-biosynthesis-i.yaml
Source revision: 9584009d49579267233124f4a1057b9425a007d9

PathwayMech reaction or cofactor edge — PathwayMech edge edge-044 records RHEA:17238 produces CHEBI:57692. This is a cross-reference to the source-scoped reaction or cofactor annotation, not proof of complete pathway flux.

Source reference · JSON Pointer /mechanistic_edges/43 · Source licence: CC-BY-4.0
ChEBI CHEBI:16238 — ChEBI provides the conjugate-form relationship linking the source chemical family to CHEBI:57692.

Source reference · JSON Pointer /ontology_relations · Source licence: CC-BY-4.0

Conjugate form required by · EC:1.3.5.1

VERIFIED · proteintraitsmech

The PTM enzyme-class record retains UniProtKB:P00363 as a named microbial exemplar. Its independently retrieved UniProt entry annotates CHEBI:57692. This link is restricted to that exemplar, not every member of EC:1.3.5.1. The UniProt cofactor note cites experimental ECO:0000269 evidence (PMIDs 10373108, 24374335 and 26644464). The cofactor is a conjugate form distinct from the neutral or differently charged seed entity.

Target chemical: CHEBI:57692

Linked source record: data/traits/function/enzymatic_activity/ec/1-3-5-1-ec1-3-5-1.yaml
Source revision: 8d08b33cfbee1e9d1c2fdb2211b82b49dd0c8b1f

PTM named enzyme exemplar — The exact named exemplar is retained in canonical_examples.

Source reference · JSON Pointer /canonical_examples/0 · Source licence: CC-BY-4.0
UniProt microbial enzyme cofactor annotation — The UniProt cofactor note cites experimental ECO:0000269 evidence (PMIDs 10373108, 24374335 and 26644464).

Source reference · JSON Pointer /comments/3 · Source licence: CC-BY-4.0
ChEBI CHEBI:16238 — The seed entity and annotated enzyme cofactor belong to the explicitly linked conjugate series.

Source reference · JSON Pointer /ontology_relations · Source licence: CC-BY-4.0

Research gaps

No research gaps recorded. This does not establish complete evidence coverage.

Curation provenance

Recorded curation events
UTC timestamp	Action and curator	Summary
2026-11-09T01:42:27Z	CREATE · cofactor-stream-c	Curate initial source-backed cofactor and scoped cross-corpus links History source