← Cofactor catalogue
Metal ion
nickel(2+)
CofactorMech:nickel · CHEBI:49786
nickel(2+) is represented by the precise ChEBI entity CHEBI:49786. Cofactor roles are chemical-context annotations; ingredient links describe chemical supply and do not establish uptake, bioavailability or a requirement for every organism.
Download source YAML · View source at this revision
Chemical identity evidence
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ChEBI CHEBI:49786 — ChEBI assigns a cofactor, coenzyme or prosthetic-group role to CHEBI:49786.
Source reference · JSON Pointer /roles_classification · Source licence: CC-BY-4.0
Scoped relationships
Provisional links retain upstream ingredient identifiers. Verified links describe the cited source context, not universal organism requirements. Conjugate forms and precursor supply are distinct relationships.
Supplied by · CHEBI:53542
PROVISIONAL · mediaingredientmech
The source is a chemically specified salt containing this metal in the +2 oxidation state; supply is chemical composition, not proof of uptake, cellular availability or enzyme occupancy.
Linked source record: data/ingredients/mapped/Nickel_II_chloride_hexahydrate.yaml
Source revision: 0529fc6bc065bfa04aba0aed234f6b0cfad6a142
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MIM ingredient identity — The cited ingredient is mapped to CHEBI:53542; this is a compound-identity assertion, not a bioavailability measurement.
Source reference · JSON Pointer /identifier · Source licence: CC-BY-4.0
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ChEBI CHEBI:53542 — The exact source salt or hydrate supplies the chemical component represented by CHEBI:34887; this is a composition relationship.
Source reference · JSON Pointer /ontology_relations · Source licence: CC-BY-4.0
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ChEBI CHEBI:34887 — The issuing ChEBI definition explicitly states nickel oxidation state +2 in nickel dichloride.
Source reference · JSON Pointer /definition · Source licence: CC-BY-4.0
Supplied by · CHEBI:34887
PROVISIONAL · mediaingredientmech
The source is a chemically specified salt containing this metal in the +2 oxidation state; supply is chemical composition, not proof of uptake, cellular availability or enzyme occupancy.
Linked source record: data/ingredients/mapped/Nicl2.yaml
Source revision: 0529fc6bc065bfa04aba0aed234f6b0cfad6a142
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MIM ingredient identity — The cited ingredient is mapped to CHEBI:34887; this is a compound-identity assertion, not a bioavailability measurement.
Source reference · JSON Pointer /identifier · Source licence: CC-BY-4.0
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ChEBI CHEBI:34887 — The issuing ChEBI definition explicitly states nickel oxidation state +2 in nickel dichloride.
Source reference · JSON Pointer /definition · Source licence: CC-BY-4.0
Supplied by · CHEBI:53542
PROVISIONAL · mediaingredientmech
The source is a chemically specified salt containing this metal in the +2 oxidation state; supply is chemical composition, not proof of uptake, cellular availability or enzyme occupancy.
Linked source record: data/ingredients/mapped/Nicl2_X_6_H2o.yaml
Source revision: 0529fc6bc065bfa04aba0aed234f6b0cfad6a142
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MIM ingredient identity — The cited ingredient is mapped to CHEBI:53542; this is a compound-identity assertion, not a bioavailability measurement.
Source reference · JSON Pointer /identifier · Source licence: CC-BY-4.0
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ChEBI CHEBI:53542 — The exact source salt or hydrate supplies the chemical component represented by CHEBI:34887; this is a composition relationship.
Source reference · JSON Pointer /ontology_relations · Source licence: CC-BY-4.0
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ChEBI CHEBI:34887 — The issuing ChEBI definition explicitly states nickel oxidation state +2 in nickel dichloride.
Source reference · JSON Pointer /definition · Source licence: CC-BY-4.0
Required by · proteintraitsmech:COFACTOR_REQ_CHEBI_49786
VERIFIED · proteintraitsmech
Conceptual requirement coverage: this PTM trait defines the requirement for the same ChEBI chemical. It is not an organism-level or enzyme-level measurement.
Linked source record: data/traits/function/cofactor_requirement/chebi/nickel-2-chebi49786.yaml
Source revision: 8d08b33cfbee1e9d1c2fdb2211b82b49dd0c8b1f
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PTM cofactor-requirement concept — The target is a CLASS trait with an explicit cross-reference to this chemical, rather than a measured protein observation.
Source reference · JSON Pointer /xrefs · Source licence: CC-BY-4.0
Used by · MetaCyc:PWY-5705
VERIFIED · pathwaymech
PathwayMech edge allantoin-glyoxylate-iii-edge-036 records UniProtKB:P77731 has_cofactor CHEBI:49786. This is a cross-reference to the source-scoped reaction or cofactor annotation, not proof of complete pathway flux. The link concerns nickel-dependent urea release by purified AllA; it does not assign a universal metal stoichiometry.
Linked source record: data/pathways/allantoin-degradation-to-glyoxylate-iii.yaml
Source revision: 9584009d49579267233124f4a1057b9425a007d9
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PathwayMech reaction or cofactor edge — PathwayMech edge allantoin-glyoxylate-iii-edge-036 records UniProtKB:P77731 has_cofactor CHEBI:49786. This is a cross-reference to the source-scoped reaction or cofactor annotation, not proof of complete pathway flux. The link concerns nickel-dependent urea release by purified AllA; it does not assign a universal metal stoichiometry.
Source reference · JSON Pointer /mechanistic_edges/35 · Source licence: CC-BY-4.0
Research gaps
- proteintraitsmech: The curated PTM link covers a cofactor-requirement concept only. A separately sourced, named enzyme exemplar requiring this exact chemical has not been curated in this seed record.