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Coenzyme
thiamine(1+) diphosphate
CofactorMech:thiamine-diphosphate · CHEBI:9532
thiamine(1+) diphosphate is represented by the precise ChEBI entity CHEBI:9532. Cofactor roles are chemical-context annotations; ingredient links describe chemical supply and do not establish uptake, bioavailability or a requirement for every organism.
Download source YAML · View source at this revision
Chemical identity evidence
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ChEBI CHEBI:9532 — ChEBI assigns a cofactor, coenzyme or prosthetic-group role to CHEBI:9532.
Source reference · JSON Pointer /roles_classification · Source licence: CC-BY-4.0
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UniProt thiamine pyrophosphate keyword — The issuing UniProt keyword identifies thiamine pyrophosphate as a coenzyme; chemical charge distinctions remain those of the ChEBI grounding.
Source reference · JSON Pointer /definition_excerpt · Source licence: CC-BY-4.0
Scoped relationships
Provisional links retain upstream ingredient identifiers. Verified links describe the cited source context, not universal organism requirements. Conjugate forms and precursor supply are distinct relationships.
Supplied by · CHEBI:9532
PROVISIONAL · mediaingredientmech
The current MIM ontology mapping exactly matches the candidate cofactor chemical identifier. This establishes a compound supply link, not organism-specific uptake or requirement.
Linked source record: data/ingredients/mapped/Thiamine_pyrophosphate.yaml
Source revision: 0529fc6bc065bfa04aba0aed234f6b0cfad6a142
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MIM ingredient identity — The cited ingredient is mapped to CHEBI:9532; this is a compound-identity assertion, not a bioavailability measurement.
Source reference · JSON Pointer /identifier · Source licence: CC-BY-4.0
Required by · proteintraitsmech:COFACTOR_REQ_CHEBI_9532
VERIFIED · proteintraitsmech
Conceptual requirement coverage: this PTM trait defines the requirement for the same ChEBI chemical. It is not an organism-level or enzyme-level measurement.
Linked source record: data/traits/function/cofactor_requirement/chebi/thiamine-1-diphosphate-chebi9532.yaml
Source revision: 8d08b33cfbee1e9d1c2fdb2211b82b49dd0c8b1f
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PTM cofactor-requirement concept — The target is a CLASS trait with an explicit cross-reference to this chemical, rather than a measured protein observation.
Source reference · JSON Pointer /xrefs · Source licence: CC-BY-4.0
Conjugate form produced by · MetaCyc:THISYN-PWY
VERIFIED · pathwaymech
PathwayMech edge thiamine-edge-058 records RHEA:15914 produces CHEBI:58937. This is a cross-reference to the source-scoped reaction or cofactor annotation, not proof of complete pathway flux. The pathway chemical is CHEBI:58937, a distinct conjugate form of CHEBI:9532; this link does not identify their charge states.
Target chemical: CHEBI:58937
Linked source record: data/pathways/thiamine-diphosphate-biosynthesis-i.yaml
Source revision: 9584009d49579267233124f4a1057b9425a007d9
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PathwayMech reaction or cofactor edge — PathwayMech edge thiamine-edge-058 records RHEA:15914 produces CHEBI:58937. This is a cross-reference to the source-scoped reaction or cofactor annotation, not proof of complete pathway flux.
Source reference · JSON Pointer /mechanistic_edges/57 · Source licence: CC-BY-4.0
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ChEBI CHEBI:9532 — ChEBI provides the conjugate-form relationship linking the source chemical family to CHEBI:58937.
Source reference · JSON Pointer /ontology_relations · Source licence: CC-BY-4.0
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ChEBI CHEBI:45931 — The intermediate conjugate form links thiamine(1+) diphosphate to its more deprotonated form.
Source reference · JSON Pointer /ontology_relations · Source licence: CC-BY-4.0
Conjugate form required by · EC:4.1.1.1
VERIFIED · proteintraitsmech
The PTM enzyme-class record retains UniProtKB:P83779 as a named microbial exemplar. Its independently retrieved UniProt entry annotates CHEBI:58937. This link is restricted to that exemplar, not every member of EC:4.1.1.1. The cofactor annotation uses ECO:0000250 by similarity to P06169; it is not a direct assay of the Candida albicans exemplar. The cofactor is a conjugate form distinct from the neutral or differently charged seed entity.
Target chemical: CHEBI:58937
Linked source record: data/traits/function/enzymatic_activity/ec/4-1-1-1-ec4-1-1-1.yaml
Source revision: 8d08b33cfbee1e9d1c2fdb2211b82b49dd0c8b1f
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PTM named enzyme exemplar — The exact named exemplar is retained in canonical_examples.
Source reference · JSON Pointer /canonical_examples/1 · Source licence: CC-BY-4.0
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UniProt microbial enzyme cofactor annotation — The cofactor annotation uses ECO:0000250 by similarity to P06169; it is not a direct assay of the Candida albicans exemplar.
Source reference · JSON Pointer /comments/3 · Source licence: CC-BY-4.0
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ChEBI CHEBI:9532 — The seed entity and annotated enzyme cofactor belong to the explicitly linked conjugate series.
Source reference · JSON Pointer /ontology_relations · Source licence: CC-BY-4.0
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ChEBI CHEBI:45931 — This intermediate charge state provides the second link in the thiamine-diphosphate conjugate series.
Source reference · JSON Pointer /ontology_relations · Source licence: CC-BY-4.0
Research gaps
- No research gaps recorded. This does not establish complete evidence coverage.