BioModels MODEL2204300001 Kefir Community Model

Community ID CommunityMech:000009

Ecological State ENGINEERED

Environment laboratory environment
ENVO:01001405

BioModels record MODEL2204300001 is a genome-scale model from the Blasche et al. kefir study and is described as a model of a microbial species participating in a kefir community.

Taxonomy

Taxon	Ontology ID	Functional Roles	Abundance
Lactobacillus kefiranofaciens	NCBITaxon:33962	PRIMARY_DEGRADER	DOMINANT
Lactococcus lactis	NCBITaxon:1358	PRIMARY_DEGRADER	N/A
Leuconostoc mesenteroides	NCBITaxon:1245	SECONDARY_FERMENTER	N/A
Lactobacillus kefiri	NCBITaxon:33963	SECONDARY_FERMENTER	N/A
Acetobacter fabarum	NCBITaxon:728467	CROSS_FEEDER	N/A
Kazachstania exigua	NCBITaxon:1380867	CROSS_FEEDER	N/A

Ecological Interactions

Taxon

Cross-feeding

Mutualism

Syntrophy

Competition

Commensalism

L. kefiranofaciens Proteolytic Support for L. mesenteroides

MUTUALISM

Source Taxon: Lactobacillus kefiranofaciens

Target Taxon: Leuconostoc mesenteroides

Metabolites: peptide (CHEBI:16670), amino acid (CHEBI:33709)

Evidence

PMID:33398099 - SUPPORT (IN_VITRO)

"proteolytic activity of L. kefiranofaciens constitutes its beneficial impact on L. mesenteroides"
PMID:33398099 - SUPPORT (IN_VITRO)

"casein peptides as well as free amino acids restore the growth of L. mesenteroides"

L. mesenteroides Lactate Provisioning to L. kefiranofaciens

MUTUALISM

Source Taxon: Leuconostoc mesenteroides

Target Taxon: Lactobacillus kefiranofaciens

Metabolites: L-lactate (CHEBI:422)

Evidence

PMID:33398099 - SUPPORT (IN_VITRO)

"lactate considerably boosted (circa three-fold) the growth of L. kefiranofaciens"
PMID:33398099 - SUPPORT (IN_VITRO)

"the metabolic cooperation between L. kefiranofaciens and L. mesenteroides is mediated by amino acids and small peptides liberated by proteolytic activity of L. kefiranofaciens, which in turn benefits from lactic acid produced by L. mesenteroides"

Acetobacter Lactate Cross-Feeding

CROSS_FEEDING

Source Taxon: Acetobacter fabarum

Metabolites: L-lactate (CHEBI:422)

Evidence

PMID:33398099 - SUPPORT (IN_VITRO)

"The majority of the mutualistic interactions, 8 in total, involved A. fabarum and a lactate-producing partner, supporting its dependency on lactate and late onset during fermentation."
PMID:33398099 - SUPPORT (IN_VITRO)

"Acetobacter sp. benefited from lactate most between 7 and 12 mg/ml"

Kazachstania Lactate-Promoted Growth

CROSS_FEEDING

Source Taxon: Kazachstania exigua

Metabolites: L-lactate (CHEBI:422)

Evidence

PMID:33398099 - SUPPORT (IN_VITRO)

"Kazachstania exigua (and Saccharomyces unisporus) were also promoted by lactate but at lower concentrations"
PMID:33398099 - SUPPORT (IN_VITRO)

"the time-windows of yeast and Acetobacter growth align well with the beneficial or inhibitory range of lactate and acetate concentration"

Associated Datasets

Dataset	Type	Repository	Accession
BioModels model file SBML file deposited as MODEL2204300001.	OTHER	OTHER	kefir_bacterium_1.xml
Primary publication Publication describing metabolic cooperation and niche partitioning in kefir.	OTHER	OTHER	PMID:33398099