An in situ infant gut microbiome study of Candida parapsilosis colonization in hospitalized infants, combining genomics, transcriptomics, and proteomics. Five unique C. parapsilosis genomes were assembled from infant gut samples and compared, providing the first multi-omics characterization of how this common cause of invasive candidiasis adapts genetically and behaviorally to the developing infant microbiome context. The work fills a gap left by pure-culture studies and informs understanding of how C. parapsilosis functions in a microbiome rather than in isolation.
Taxonomy
| Taxon | Ontology ID | Functional Roles | Abundance |
|---|---|---|---|
| Candida parapsilosis | NCBITaxon:5480 |
PRIMARY_DEGRADER
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N/A |
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Ecological Interactions
Taxon
Cross-feeding
Mutualism
Syntrophy
Competition
Commensalism
Niche partitioning
Colonization facilitation
Strain competition
Predation
Genetic and Behavioral Adaptation in Microbiome Context
COMMENSALISMEvidence
-
PMID:34154658 - SUPPORT (IN_VIVO)"Genetic and behavioral adaptation of Candida parapsilosis to the microbiome of hospitalized infants revealed by in situ genomics, transcriptomics, and proteomics"
Microbiome Context Versus Pure Culture
COMMENSALISMEvidence
-
PMID:34154658 - SUPPORT (IN_VIVO)"C. parapsilosis has been primarily studied in pure culture, leaving gaps in understanding of its function in a microbiome context"
External Resources
| Name | Repository | Resource ID |
|---|---|---|
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Primary publication for the C. parapsilosis hospitalized-infant community
PubMed record for the West et al. 2021 Microbiome paper. |
OTHER | PMID:34154658 |
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DOI landing page
DOI link to the Microbiome paper. |
OTHER | doi:10.1186/s40168-021-01085-y |
Environmental Factors
| Factor | Value | Unit |
|---|---|---|
| Clinical setting | hospitalized infants | N/A |
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