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Streptococcus mutans - Veillonella parvula Adult Severe Caries Model

Community ID CommunityMech:000085
Ecological State ENGINEERED
Environment adult severe caries plaque biofilm
ENVO:01001034

A defined dual-species oral biofilm model for adult severe caries pairing Streptococcus mutans with the ASC-associated pathobiont Veillonella parvula. The coculture increases mature biofilm formation, acid resistance, oxidative stress tolerance, and rodent caries severity relative to Streptococcus mutans alone.

Taxonomy

Taxon Ontology ID Functional Roles Abundance
Streptococcus mutans NCBITaxon:1309 N/A
  • PMID:39345197 - SUPPORT (IN_VIVO)
    "This study is focused on the composition of dental plaque microbiome profiles in order to identify disease-relevant species and to investigate into their interactions with the S. mutans."
Veillonella parvula NCBITaxon:29466 DOMINANT
  • PMID:39345197 - SUPPORT (IN_VIVO)
    "The most significantly abundant taxon found associated with ASC was V. parvula."

Ecological Interactions

Ecological interaction network for Streptococcus mutans - Veillonella parvula Adult Severe Caries Model Bipartite graph where circle nodes represent taxa and colored rectangles represent ecological interactions (cross-feeding, mutualism, syntrophy, competition, commensalism).
Taxon
Cross-feeding
Mutualism
Syntrophy
Competition
Commensalism
Niche partitioning
Colonization facilitation
Strain competition
Predation

Veillonella parvula Promotion of Streptococcus mutans Biofilm Virulence

COLONIZATION_FACILITATION

Source Taxon: Veillonella parvula

Target Taxon: Streptococcus mutans

Evidence

  • PMID:39345197 - SUPPORT (IN_VIVO)
    "In vitro experiments found that V. parvula can effectively promote S. mutans mature biofilm formation with enhanced acid resistance, hydrogen peroxide detoxicity, and biofilm virulence."

Pathobiont-Driven Adult Severe Caries Exacerbation

COLONIZATION_FACILITATION

Source Taxon: Veillonella parvula

Target Taxon: Streptococcus mutans

Evidence

  • PMID:39345197 - SUPPORT (IN_VIVO)
    "Rodent model experiments revealed that V. parvula was incapable of causing disease on its own, but it significantly heightened the biofilm virulence of S. mutans when being co-infected and augmented the progression, quantity, and severity of dental caries."