{"cross_mech":[],"family":{"alphafold_models":17571,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family is the Small Multidrug Resistance (SMR) family. Several members have been shown to export a range of toxins, including ethidium bromide ([[cite:PUB00019898]] and quaternary ammonium compounds [[cite:PUB00002174]], through coupling with proton influx [[cite:PUB00019899]].","domain_architectures":11,"interpro_id":"IPR045324","known_evidence_count":null,"matches":28666,"name":"Small Multidrug Resistance protein","partial_evidence_count":null,"pfam_id":"PF00893","proteins":28663,"proteomes":13207,"short_name":"Multi_Drug_Res","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF00893","structures":20,"taxa":18029,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF00893.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":17571,"domain_architectures":11,"matches":28666,"proteins":28663,"proteomes":13207,"structures":20,"taxa":18029},"curation_status":"SEEDED","description":"This family is the Small Multidrug Resistance (SMR) family. Several members have been shown to export a range of toxins, including ethidium bromide ([[cite:PUB00019898]] and quaternary ammonium compounds [[cite:PUB00002174]], through coupling with proton influx [[cite:PUB00019899]].","id":"Pfam:PF00893","interpro_id":"InterPro:IPR045324","name":"Small Multidrug Resistance protein","pfam_id":"PF00893","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Multi_Drug_Res","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF00893"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF00893.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"aa45acf527139c7dccd1aa34e8efb65b742caf6f70443c51d0746787ec498df6"}},"protein_examples":{"candidate_count":10,"discovery_scanned":true,"example_count":10,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Bacillus subtilis (strain 168)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/multi-drug-res-pf00893.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF00893","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/multi-drug-res-pf00893.yaml"}],"pfam_ids":["PF00893"],"protein_name":"Uncharacterized membrane protein YvdR","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAWFLLVIAGIEEIIAAIAMKYIDGTRKKWPIIVMTVGFGLSFYCLSQAMIVLPAGVAYAVWTGIGSIGVSAVGLIWFKERFQLSQVISLCLILAGVIGLRLTSSS","sequence_length":106,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"4d07be1c45e4ba864a56ac743ddd46a50bc4cb1e9af8c95f0f9dd0dbe6e2842b","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/O06999.json","taxon_id":"224308","uniprot_accession":"O06999","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Bacillus subtilis (strain 168)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/multi-drug-res-pf00893.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF00893","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/multi-drug-res-pf00893.yaml"}],"pfam_ids":["PF00893"],"protein_name":"Uncharacterized membrane protein YvdS","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MNWVLVFIAGLLEVVWASSLKHADSLLDWIIIFILIAVSFILLIRSYQKIPMAAAYTVFVGIGTVGTYLTGIVLGESFSAAQMFFLALLLAGILGMKLFTKESKSQPGGEK","sequence_length":111,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"f7bd1e6340b4b09d77f6234aa923bca543d475d7ebf3aec8027e154b936f50eb","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/O32262.json","taxon_id":"224308","uniprot_accession":"O32262","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Bacillus subtilis (strain 168)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/protein_family/ncbifam/smr-family-multidrug-efflux-transporter-ebra-nf051481.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:NF051481","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/protein_family/ncbifam/smr-family-multidrug-efflux-transporter-ebra-nf051481.yaml"}],"pfam_ids":["PF00893"],"protein_name":"Multidrug resistance protein EbrA","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MLIGYIFLTIAICSESIGAAMLKVSDGFKKWKPSALVVIGYSLAFYMLSLTLNHIPLSLSYATWSGAGTVLTTVIGVKWFKEDLNAKGLIGILLLLSGVVLLNWP","sequence_length":105,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"1d811d866d6ff4f01aa3845c0b32f1b8477918c60284ed939ba2e90306acda81","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P0CW80.json","taxon_id":"224308","uniprot_accession":"P0CW80","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Bacillus subtilis (strain 168)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/protein_family/ncbifam/smr-family-multidrug-efflux-transporter-ebrb-nf051482.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:NF051482","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/protein_family/ncbifam/smr-family-multidrug-efflux-transporter-ebrb-nf051482.yaml"}],"pfam_ids":["PF00893"],"protein_name":"Multidrug resistance protein EbrB","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MRGLLYLALAIVSEVFGSTMLKLSEGFTQAWPIAGVIVGFLSAFTFLSFSLKTIDLSSAYATWSGVGTALTAIVGFLLFGETISLKGVFGLTLVIAGVVVLNQSKAHAEDKKQTACE","sequence_length":117,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"0e5e7735c762d92435f867fafcdf64f260c15d5795ad1de0f59cd7c9d4f005f6","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P0CW82.json","taxon_id":"224308","uniprot_accession":"P0CW82","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli (strain K12)","origins":[{"cited_uniprot_accession":"P23895","commit":"937ba6254eb987adcbd92e82b21b2ce8651dc5e3","link_basis":["uniprot_pfam_xref"],"mech":"CellStructureMech","path":"data/structures/other/emre_multidrug_transporter_complex.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:1990207","section":"uniprot_accession","url":"https://github.com/CultureBotAI/CellStructureMech/blob/937ba6254eb987adcbd92e82b21b2ce8651dc5e3/data/structures/other/emre_multidrug_transporter_complex.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/amino-acid-betaine-transmembrane-transporter-activity-go0015199.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0015199","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/amino-acid-betaine-transmembrane-transporter-activity-go0015199.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/choline-transmembrane-transporter-activity-go0015220.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0015220","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/choline-transmembrane-transporter-activity-go0015220.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/cellular-response-to-xenobiotic-stimulus-go0071466.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0071466","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/cellular-response-to-xenobiotic-stimulus-go0071466.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/choline-transport-go0015871.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0015871","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/choline-transport-go0015871.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/glycine-betaine-transport-go0031460.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0031460","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/glycine-betaine-transport-go0031460.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/xenobiotic-metabolic-process-go0006805.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0006805","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/xenobiotic-metabolic-process-go0006805.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/xenobiotic-transport-go0042908.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0042908","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/xenobiotic-transport-go0042908.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/protein_family/ncbifam/emre-family-multidrug-efflux-smr-transporter-nf007087.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:NF007087","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/protein_family/ncbifam/emre-family-multidrug-efflux-smr-transporter-nf007087.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/protein_family/ncbifam/multidrug-efflux-smr-transporter-emre-nf042984.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:NF042984","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/protein_family/ncbifam/multidrug-efflux-smr-transporter-emre-nf042984.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/multi-drug-res-pf00893.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF00893","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/multi-drug-res-pf00893.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/multidrug-transporter-emre-superfamily-ipr037185.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR037185","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/multidrug-transporter-emre-superfamily-ipr037185.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/1-10-3730-20-1-10-3730-20.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:1.10.3730.20","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/1-10-3730-20-1-10-3730-20.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:P23895","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF00893"],"protein_name":"Multidrug transporter EmrE","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"ef2609217dd96e4497a66ea32c6e1f73d348cd3934b723ec6fa4df9e0acb7927","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MNPYIYLGGAILAEVIGTTLMKFSEGFTRLWPSVGTIICYCASFWLLAQTLAYIPTGIAYAIWSGVGIVLISLLSWGFFGQRLDLPAIIGMMLICAGVLIINLLSRSTPH","sequence_length":110,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"ef2609217dd96e4497a66ea32c6e1f73d348cd3934b723ec6fa4df9e0acb7927","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P23895.json","taxon_id":"83333","uniprot_accession":"P23895","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Bacillus subtilis (strain 168)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/multi-drug-res-pf00893.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF00893","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/multi-drug-res-pf00893.yaml"}],"pfam_ids":["PF00893"],"protein_name":"Probable guanidinium efflux system subunit GdnC","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKWGLVVLAAVFEVVWVIGLKHADSALTWSGTAIGIIFSFYLLMKATHSLPVGTVYAVFTGLGTAGTVLSEIVLFHEPVGWPKLLLIGVLLIGVIGLKLVTQDETEEKGGEA","sequence_length":112,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"077e0138b899dbd5ba7f722fb2f90018f3e6bc3ea0645bc45a513298b5f3c60b","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P49856.json","taxon_id":"224308","uniprot_accession":"P49856","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Bacillus subtilis (strain 168)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/multi-drug-res-pf00893.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF00893","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/multi-drug-res-pf00893.yaml"}],"pfam_ids":["PF00893"],"protein_name":"Probable guanidinium efflux system subunit GdnD","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASFSLLSYAMETTPMGTAYAVWTGIGTAGGALIGILFYKEQKDAKRIFFIALILCSAVGLKILS","sequence_length":105,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"170ec6f8b542462f5d5cbc077f47c631caef3891ac2ed8191540f81bff339490","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/P49857.json","taxon_id":"224308","uniprot_accession":"P49857","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli (strain K12)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/amino-acid-betaine-transmembrane-transporter-activity-go0015199.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0015199","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/amino-acid-betaine-transmembrane-transporter-activity-go0015199.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/spermidine-transmembrane-transporter-activity-go0015606.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0015606","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/spermidine-transmembrane-transporter-activity-go0015606.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/glycine-betaine-transport-go0031460.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0031460","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/glycine-betaine-transport-go0031460.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/spermidine-transmembrane-transport-go1903711.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:1903711","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/spermidine-transmembrane-transport-go1903711.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/protein_family/ncbifam/multidrug-spermidine-efflux-smr-transporter-subunit-mdti-nf007934.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:NF007934","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/protein_family/ncbifam/multidrug-spermidine-efflux-smr-transporter-subunit-mdti-nf007934.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/multi-drug-res-pf00893.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF00893","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/multi-drug-res-pf00893.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/multidrug-transporter-emre-superfamily-ipr037185.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR037185","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/multidrug-transporter-emre-superfamily-ipr037185.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/1-10-3730-20-1-10-3730-20.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:1.10.3730.20","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/1-10-3730-20-1-10-3730-20.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:P69210","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF00893"],"protein_name":"Spermidine export protein MdtI","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"77c7eefca44d6d6c755793a2f990e2d1b682c2dcef3c67a92c13e1adf3f2362f","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MAQFEWVHAAWLALAIVLEIVANVFLKFSDGFRRKIFGLLSLAAVLAAFSALSQAVKGIDLSVAYALWGGFGIAATLAAGWILFGQRLNRKGWIGLVLLLAGMIMVKLA","sequence_length":109,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"77c7eefca44d6d6c755793a2f990e2d1b682c2dcef3c67a92c13e1adf3f2362f","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P69210.json","taxon_id":"83333","uniprot_accession":"P69210","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli (strain K12)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/amino-acid-betaine-transmembrane-transporter-activity-go0015199.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0015199","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/amino-acid-betaine-transmembrane-transporter-activity-go0015199.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/spermidine-transmembrane-transporter-activity-go0015606.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0015606","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/spermidine-transmembrane-transporter-activity-go0015606.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/glycine-betaine-transport-go0031460.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0031460","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/glycine-betaine-transport-go0031460.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/spermidine-transmembrane-transport-go1903711.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:1903711","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/spermidine-transmembrane-transport-go1903711.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/protein_family/ncbifam/multidrug-spermidine-efflux-smr-transporter-subunit-mdtj-nf007767.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:NF007767","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/protein_family/ncbifam/multidrug-spermidine-efflux-smr-transporter-subunit-mdtj-nf007767.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/multi-drug-res-pf00893.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF00893","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/multi-drug-res-pf00893.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/multidrug-transporter-emre-superfamily-ipr037185.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR037185","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/multidrug-transporter-emre-superfamily-ipr037185.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/1-10-3730-20-1-10-3730-20.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:1.10.3730.20","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/1-10-3730-20-1-10-3730-20.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:P69212","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF00893"],"protein_name":"Spermidine export protein MdtJ","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"12a79db185d28e2bb17cf0edfca9dc5941e12af7b252d3fbe7391a53e64692e0","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MYIYWILLGLAIATEITGTLSMKWASVSEGNGGFILMLVMISLSYIFLSFAVKKIALGVAYALWEGIGILFITLFSVLLFDESLSLMKIAGLTTLVAGIVLIKSGTRKARKPELEVNHGAV","sequence_length":121,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"12a79db185d28e2bb17cf0edfca9dc5941e12af7b252d3fbe7391a53e64692e0","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P69212.json","taxon_id":"83333","uniprot_accession":"P69212","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli (strain K12)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/protein_family/ncbifam/quaternary-ammonium-compound-efflux-smr-transporter-suge-nf008512.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:NF008512","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/protein_family/ncbifam/quaternary-ammonium-compound-efflux-smr-transporter-suge-nf008512.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/multi-drug-res-pf00893.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF00893","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/multi-drug-res-pf00893.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:P69937","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF00893"],"protein_name":"Guanidinium exporter","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"0083070eb5093d988f31d0ad231326109da0338529af1d8f9176c61775a2096c","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MSWIILVIAGLLEVVWAVGLKYTHGFSRLTPSVITVTAMIVSMALLAWAMKSLPVGTAYAVWTGIGAVGAAITGIVLLGESANPMRLASLALIVLGIIGLKLSTH","sequence_length":105,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"0083070eb5093d988f31d0ad231326109da0338529af1d8f9176c61775a2096c","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P69937.json","taxon_id":"83333","uniprot_accession":"P69937","uniprot_release":"2026_03"}],"pfam_id":"PF00893","short_name":"Multi_Drug_Res","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
