{"cross_mech":[],"family":{"alphafold_models":15274,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"Hydration of NAD(P)H to NAD(P)HX, which inhibits several dehydrogenases, is corrected by an ATP-dependent dehydratase and an epimerase. The ATP-dependent dehydratase has been identified as the product of the vertebrate Carkd (carbohydrate kinase domain) gene [[cite:PUB00073185],[cite:PUB00100876]]. Variants of this enzyme leads to deficient NADHX repair mitochondrial dysfunction in humans, associated with a lethal neurometabolic disorder in early childhood [[cite:PUB00100876]]. In E. coli, it is found as the C-terminal domain of a bifunctional enzyme (YjeF) that also includes the epimerase and uses ADP instead of ATP [[cite:PUB00060794]]. These enzymes are widespread in eukaryotes, prokaryotes, and archaea.","domain_architectures":88,"interpro_id":"IPR000631","known_evidence_count":null,"matches":22644,"name":"NAD(P)H-hydrate dehydratase","partial_evidence_count":null,"pfam_id":"PF01256","proteins":22302,"proteomes":19898,"short_name":"Carb_kinase","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01256","structures":37,"taxa":32358,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF01256.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":15274,"domain_architectures":88,"matches":22644,"proteins":22302,"proteomes":19898,"structures":37,"taxa":32358},"curation_status":"SEEDED","description":"Hydration of NAD(P)H to NAD(P)HX, which inhibits several dehydrogenases, is corrected by an ATP-dependent dehydratase and an epimerase. The ATP-dependent dehydratase has been identified as the product of the vertebrate Carkd (carbohydrate kinase domain) gene [[cite:PUB00073185],[cite:PUB00100876]]. Variants of this enzyme leads to deficient NADHX repair mitochondrial dysfunction in humans, associated with a lethal neurometabolic disorder in early childhood [[cite:PUB00100876]]. In E. coli, it is found as the C-terminal domain of a bifunctional enzyme (YjeF) that also includes the epimerase and uses ADP instead of ATP [[cite:PUB00060794]]. These enzymes are widespread in eukaryotes, prokaryotes, and archaea.","id":"Pfam:PF01256","interpro_id":"InterPro:IPR000631","name":"NAD(P)H-hydrate dehydratase","pfam_id":"PF01256","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Carb_kinase","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01256"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF01256.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"e5b7e6d3230518b60eb4ad27ef24872bb8d99be1fee73ed9e098b0c9b50eea0a"}},"protein_examples":{"candidate_count":12,"discovery_scanned":true,"example_count":12,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Aquifex aeolicus (strain VF5)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/pattern/yjef-c-2.yaml","qualification_status":"NOT_ASSESSED","record_id":"PROSITE:PS01050","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/pattern/yjef-c-2.yaml"}],"pfam_ids":["PF01256","PF03853"],"protein_name":"Bifunctional NAD(P)H-hydrate repair enzyme Nnr","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKILKAHEMSSIDNKTIEEIGIPSLVLMENASKGVFENIRKYFPDAKNILVVAGKGNNGGDGLALARHLYLNGFSVDIFLAFGEVKGDAKTQLEILKKIGIEPLKKKPDFKEYDLIVDAIFGTGFQPPVKGEVANLIKEINNSSVPIVSIDIPSGLSADTGESFEPSVKADLTVTFQFPKICHYLYPAAKKCGKVEVVDISIPEFLAKDVKRDLLRKSDLKPYKREPDTYKTKEGSVLLVGGSVGKTGAVIMSAKAASRAGAGLVTVGIPRELNPIFESLLIEEMSLPLSGTSRLSVFCVEEILELKDRFHALGIGMGMDRYEEGQDIVISLLEKWEKPILIDADGINNLADYGDYTPLKDREIPAVLTPHIGEFSRLTGYDTKTITYNQIDIAQEFSEKNRCYLVLKGARTVISTPDGRAYLFADGTPALAKGGTGDVLAGILTALIAKMDTEEALKLGVYLHGLAGKVAEKKLHTESVKATDVTESLPEAFREIYVN","sequence_length":499,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"fa7aeaa706736607e33fae3ac5d8024c5af947f5f506068853da86449cca5909","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/O67377.json","taxon_id":"224324","uniprot_accession":"O67377","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli (strain K12)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/carb-kinase-pf01256.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF01256","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/carb-kinase-pf01256.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/pattern/yjef-c-1.yaml","qualification_status":"NOT_ASSESSED","record_id":"PROSITE:PS01049","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/pattern/yjef-c-1.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/pattern/yjef-c-2.yaml","qualification_status":"NOT_ASSESSED","record_id":"PROSITE:PS01050","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/pattern/yjef-c-2.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:P31806","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF01256","PF03853"],"protein_name":"Bifunctional NAD(P)H-hydrate repair enzyme Nnr","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"1fa6052bd095a5589e4beff0cba7409bb19ce42e8fda756dc540f5f001975974","sequence_version":2,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MTDHTMKKNPVSIPHTVWYADDIRRGEREAADVLGLTLYELMLRAGEAAFQVCRSAYPDARHWLVLCGHGNNGGDGYVVARLAKAVGIEVTLLAQESDKPLPEEAALAREAWLNAGGEIHASNIVWPESVDLIVDALLGTGLRQAPRESISQLIDHANSHPAPIVAVDIPSGLLAETGATPGAVINADHTITFIALKPGLLTGKARDVTGQLHFDSLGLDSWLAGQETKIQRFSAEQLSHWLKPRRPTSHKGDHGRLVIIGGDHGTAGAIRMTGEAALRAGAGLVRVLTRSENIAPLLTARPELMVHELTMDSLTESLEWADVVVIGPGLGQQEWGKKALQKVENFRKPMLWDADALNLLAINPDKRHNRVITPHPGEAARLLGCSVAEIESDRLHCAKRLVQRYGGVAVLKGAGTVVAAHPDALGIIDAGNAGMASGGMGDVLSGIIGALLGQKLSPYDAACAGCVAHGAAADVLAARFGTRGMLATDLFSTLQRIVNPEVTDKNHDESSNSAP","sequence_length":515,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"1fa6052bd095a5589e4beff0cba7409bb19ce42e8fda756dc540f5f001975974","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/P31806.json","taxon_id":"83333","uniprot_accession":"P31806","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Caenorhabditis elegans","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/atp-dependent-nad-p-h-hydrate-dehydratase-activity-go0047453.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0047453","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/atp-dependent-nad-p-h-hydrate-dehydratase-activity-go0047453.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/conservation/interpro/carbohydrate-kinase-predicted-conserved-site-ipr017953.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR017953","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/conservation/interpro/carbohydrate-kinase-predicted-conserved-site-ipr017953.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/b-subtilis-yxko-protein-of-unknown-function-and-related-proteins-based-cd01171.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd01171","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/b-subtilis-yxko-protein-of-unknown-function-and-related-proteins-based-cd01171.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/atp-adp-dependent-s-nad-p-h-hydrate-dehydratase-ipr000631.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR000631","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/atp-adp-dependent-s-nad-p-h-hydrate-dehydratase-ipr000631.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/ncbifam/nad-p-h-hydrate-dehydratase-tigr00196.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:TIGR00196","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/ncbifam/nad-p-h-hydrate-dehydratase-tigr00196.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/profile/yjef-c-3.yaml","qualification_status":"NOT_ASSESSED","record_id":"PROSITE:PS51383","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/profile/yjef-c-3.yaml"}],"pfam_ids":["PF01256"],"protein_name":"ATP-dependent (S)-NAD(P)H-hydrate dehydratase","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MDHFIKLLPKLTPHLRKGDCGKMGVIGGSLEYTGAPYFAASSASRLGADLIHIFCDPDAAQVIKGYSPDLIVHPGMTANSIIPKLSRMDAIVIGPGLGRNPNIWPLMQELFEFVRNRDVPFVIDGDGLWFVSEHIEKFPRQMSATVLTPNIVEFSRLCKSALGEEDVLNVRNNSQLQHLAAELSRKMNVTIYLKGEVDLVVTPNGEVSKCSTESSLRRCGGQGDVTAGSLGLFLYWAKKNLGDDWTSAHHEAGIASSWLVRTAGRRAFEKHGRSMNTPLLLDEIPKLVRDVETREMKDTVHTDSSKH","sequence_length":307,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"53e80471806af9a95e603b371d6c0fce605e4868fa574271e5e62f44bc75c93f","sequence_version":3,"source_url":"https://rest.uniprot.org/uniprotkb/P32740.json","taxon_id":"6239","uniprot_accession":"P32740","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/atp-dependent-nad-p-h-hydrate-dehydratase-activity-go0047453.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0047453","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/atp-dependent-nad-p-h-hydrate-dehydratase-activity-go0047453.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/conservation/interpro/carbohydrate-kinase-predicted-conserved-site-ipr017953.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR017953","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/conservation/interpro/carbohydrate-kinase-predicted-conserved-site-ipr017953.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/pattern/yjef-c-1.yaml","qualification_status":"NOT_ASSESSED","record_id":"PROSITE:PS01049","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/pattern/yjef-c-1.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/pattern/yjef-c-2.yaml","qualification_status":"NOT_ASSESSED","record_id":"PROSITE:PS01050","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/pattern/yjef-c-2.yaml"}],"pfam_ids":["PF01256"],"protein_name":"ATP-dependent (S)-NAD(P)H-hydrate dehydratase","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MLAELSHRELIKLAQKRCIPPLLPKFHKGQSGGRVCIIGGCEDYTGAPYFSANATALMGCDLTHVICEYNAGTVIKSYTPNLMVHPYLRMSNTKLDVDMDEQRKKINSLLDRIHVVVIGPGLGRDPLMLKSIKDIIRYILEKHEGKIPLVIDADGLFLVTQDSEVKEMLKSYPKGRVILTPNVVEFKRLCDAIGKKGDSHSEMGSLIAQELNCIVVEKGQSDKIFSPDSEKDMLTNSEEGSNKRVGGQGDTLTGAISCMLAFSRAMYDFKICEQEEKGESSNDKPLKNWVDYAMLSCYAGCTITRECSRLGFKAKGRAMQTTDLNDRVGEVFAKLFG","sequence_length":337,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"beb44bd8327911d93843a7ffd8a654d5b9f5a52768e98270635d619cf4cd9ae0","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P36059.json","taxon_id":"559292","uniprot_accession":"P36059","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mycobacterium leprae (strain TN)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/pattern/yjef-c-2.yaml","qualification_status":"NOT_ASSESSED","record_id":"PROSITE:PS01050","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/pattern/yjef-c-2.yaml"}],"pfam_ids":["PF01256","PF03853"],"protein_name":"Bifunctional NAD(P)H-hydrate repair enzyme Nnr","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MRHYYSVAAIRDAEASLLASLPDGVLMKRAAYGLASVIIRELAVRTGGVTGRRVCAVVGSGDNGGDALWAATFLRRRGAAADAVLLNPDRVHRKALVAFRKAGGRIVENVSAATDLVIDGVVGISGSGPLRPAAAAVFATVSASGVPVVAVDLPSGIDVVTGVINGPAVHAALTVTFGGLKPVHALADCGDVTLVDIGLDLPDSDILGLQAADVAAYWPVPGVHDDKYTQGVTGVLAGSSTYPGAAVLCTGAAVAATSGMVRYAGSAYTQVLAHWPEVIASATPTAAGRVQSWVVGPGLGIDATATAALWFALETDLPVLVDADGLTMLAAHPDLVINRNAPTVLTPHASEFARLAGTPPGDDRVGACRKLADSFGATVLLKGNVTVIADPGGPVYLNPAGQSWAATAGSGDVLSGMIGALLAAGLPAAEAAAAAAFVHARAAALSAADPGPGDVPTSASRMVSHIRTALAAL","sequence_length":473,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"0a62c93856fcb54e1853aad72c40b47cb710e58df94535e9422d66a5678819b8","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/P37391.json","taxon_id":"272631","uniprot_accession":"P37391","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Bacillus subtilis (strain 168)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/adp-dependent-nad-p-h-hydrate-dehydratase-activity-go0052855.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0052855","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/adp-dependent-nad-p-h-hydrate-dehydratase-activity-go0052855.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/nad-p-hx-epimerase-activity-go0052856.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0052856","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/nad-p-hx-epimerase-activity-go0052856.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/metabolite-repair-go0110051.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0110051","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/metabolite-repair-go0110051.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/nicotinamide-nucleotide-metabolic-process-go0046496.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0046496","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/nicotinamide-nucleotide-metabolic-process-go0046496.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/conservation/interpro/carbohydrate-kinase-predicted-conserved-site-ipr017953.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR017953","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/conservation/interpro/carbohydrate-kinase-predicted-conserved-site-ipr017953.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/b-subtilis-yxko-protein-of-unknown-function-and-related-proteins-based-cd01171.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd01171","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/b-subtilis-yxko-protein-of-unknown-function-and-related-proteins-based-cd01171.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/atp-adp-dependent-s-nad-p-h-hydrate-dehydratase-ipr000631.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR000631","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/atp-adp-dependent-s-nad-p-h-hydrate-dehydratase-ipr000631.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/ncbifam/nad-p-h-hydrate-dehydratase-tigr00196.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:TIGR00196","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/ncbifam/nad-p-h-hydrate-dehydratase-tigr00196.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/pattern/yjef-c-1.yaml","qualification_status":"NOT_ASSESSED","record_id":"PROSITE:PS01049","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/pattern/yjef-c-1.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/pattern/yjef-c-2.yaml","qualification_status":"NOT_ASSESSED","record_id":"PROSITE:PS01050","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/pattern/yjef-c-2.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/profile/yjef-c-3.yaml","qualification_status":"NOT_ASSESSED","record_id":"PROSITE:PS51383","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/profile/yjef-c-3.yaml"}],"pfam_ids":["PF01256"],"protein_name":"ADP-dependent (S)-NAD(P)H-hydrate dehydratase","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MNVPFWTEEHVRATLPERDAESHKGTYGTALLLAGSDDMPGAALLAGLGAMRSGLGKLVIGTSENVIPLIVPVLPEATYWRDGWKKAADAQLEETYRAIAIGPGLPQTESVQQAVDHVLTADCPVILDAGALAKRTYPKREGPVILTPHPGEFFRMTGVPVNELQKKRAEYAKEWAAQLQTVIVLKGNQTVIAFPDGDCWLNPTGNGALAKGGTGDTLTGMILGMLCCHEDPKHAVLNAVYLHGACAELWTDEHSAHTLLAHELSDILPRVWKRFE","sequence_length":276,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"61e662b7b52560983a900ef37414b180f524c295a338180c6169120e4c3e84dc","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P94368.json","taxon_id":"224308","uniprot_accession":"P94368","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/pattern/yjef-c-1.yaml","qualification_status":"NOT_ASSESSED","record_id":"PROSITE:PS01049","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/pattern/yjef-c-1.yaml"}],"pfam_ids":["PF01256","PF03853"],"protein_name":"Bifunctional NAD(P)H-hydrate repair enzyme Nnr","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MRHYYSVDTIRAAEAPLLASLPDGALMRRAAFGLATEIGRELTARTGGVVGRRVCAVVGSGDNGGDALWAATFLRRRGAAADAVLLNPDRTHRKALAAFTKSGGRLVESVSAATDLVIDGVVGISGSGPLRPAAAQVFAAVQAAAIPVVAVDIPSGIDVATGAITGPAVHAALTVTFGGLKPVHALADCGRVVLVDIGLDLAHTDVLGFEATDVAARWPVPGPRDDKYTQGVTGVLAGSSTYPGAAVLCTGAAVAATSGMVRYAGTAHAEVLAHWPEVIASPTPAAAGRVQAWVVGPGLGTDEAGAAALWFALDTDLPVLVDADGLTMLADHPDLVAGRNAPTVLTPHAGEFARLAGAPPGDDRVGACRQLADALGATVLLKGNVTVIADPGGPVYLNPAGQSWAATAGSGDVLSGMIGALLASGLPSGEAAAAAAFVHARASAAAAADPGPGDAPTSASRISGHIRAALAAL","sequence_length":473,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"1d53b9ab8da34c654b32a834dc0882c5b4086c1246e623655432bdeabec2c25c","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P9WF11.json","taxon_id":"83332","uniprot_accession":"P9WF11","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/atp-dependent-nad-p-h-hydrate-dehydratase-activity-go0047453.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0047453","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/atp-dependent-nad-p-h-hydrate-dehydratase-activity-go0047453.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/metabolite-repair-go0110051.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0110051","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/metabolite-repair-go0110051.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/nicotinamide-nucleotide-metabolic-process-go0046496.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0046496","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/nicotinamide-nucleotide-metabolic-process-go0046496.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/b-subtilis-yxko-protein-of-unknown-function-and-related-proteins-based-cd01171.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd01171","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/b-subtilis-yxko-protein-of-unknown-function-and-related-proteins-based-cd01171.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/atp-adp-dependent-s-nad-p-h-hydrate-dehydratase-ipr000631.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR000631","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/atp-adp-dependent-s-nad-p-h-hydrate-dehydratase-ipr000631.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/ncbifam/nad-p-h-hydrate-dehydratase-tigr00196.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:TIGR00196","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/ncbifam/nad-p-h-hydrate-dehydratase-tigr00196.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/carb-kinase-pf01256.yaml","qualification_status":"QUALIFIED","record_id":"Pfam:PF01256","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/carb-kinase-pf01256.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/profile/yjef-c-3.yaml","qualification_status":"NOT_ASSESSED","record_id":"PROSITE:PS51383","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/profile/yjef-c-3.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q8IW45","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF01256"],"protein_name":"ATP-dependent (S)-NAD(P)H-hydrate dehydratase","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"06619253ad684911a3dc05d829613f516c0eb1e7731e4603246d52d01d1884c7","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MVTRAGAGTAVAGAVVVALLSAALALYGPPLDAVLERAFSLRKAHSIKDMENTLQLVRNIIPPLSSTKHKGQDGRIGVVGGCQEYTGAPYFAAISALKVGADLSHVFCASAAAPVIKAYSPELIVHPVLDSPNAVHEVEKWLPRLHALVVGPGLGRDDALLRNVQGILEVSKARDIPVVIDADGLWLVAQQPALIHGYRKAVLTPNHVEFSRLYDAVLRGPMDSDDSHGSVLRLSQALGNVTVVQKGERDILSNGQQVLVCSQEGSSRRCGGQGDLLSGSLGVLVHWALLAGPQKTNGSSPLLVAAFGACSLTRQCNHQAFQKHGRSTTTSDMIAEVGAAFSKLFET","sequence_length":347,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"06619253ad684911a3dc05d829613f516c0eb1e7731e4603246d52d01d1884c7","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8IW45.json","taxon_id":"9606","uniprot_accession":"Q8IW45","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Arabidopsis thaliana","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/atp-dependent-nad-p-h-hydrate-dehydratase-activity-go0047453.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0047453","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/atp-dependent-nad-p-h-hydrate-dehydratase-activity-go0047453.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/metabolite-repair-go0110051.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0110051","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/metabolite-repair-go0110051.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/b-subtilis-yxko-protein-of-unknown-function-and-related-proteins-based-cd01171.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd01171","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/b-subtilis-yxko-protein-of-unknown-function-and-related-proteins-based-cd01171.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/atp-adp-dependent-s-nad-p-h-hydrate-dehydratase-ipr000631.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR000631","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/atp-adp-dependent-s-nad-p-h-hydrate-dehydratase-ipr000631.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/ncbifam/nad-p-h-hydrate-dehydratase-tigr00196.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:TIGR00196","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/ncbifam/nad-p-h-hydrate-dehydratase-tigr00196.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/profile/yjef-c-3.yaml","qualification_status":"NOT_ASSESSED","record_id":"PROSITE:PS51383","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/profile/yjef-c-3.yaml"}],"pfam_ids":["PF01256"],"protein_name":"ATP-dependent (S)-NAD(P)H-hydrate dehydratase","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MLVKPSIISGLVRLTSHSPSSSSSVLRRQEFLVRTLCGSPIIRAMSSTSEADAESVLRTVTPSLDLKRHKGQAGKIAVIGGCREYTGAPYFAAISALKIGADLSHVFCTKDAAPVIKSYSPELIVHPVLEESYSISQLSEEDKREVQDKVLGEVGKWMERFDCLVIGPGLGRDPFLLECVSIIMLLAKKSNVPFVIDGDGLFLVTNSIDLVHSYPLAVLTPNVNEYKRLVQKVLNCEVDEQNAEDQLRSLAKQIGGVTILRKGKSDLISNGETVKSVSIYGSPRRCGGQGDILSGGVAVFLSWAQQLKSDPESPSENPAILGCIAASGLLRKAASLAFTKHKRSTLTSDIIECLGESLEDICPAS","sequence_length":365,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"c3edd2a5ac7f1411edc3a01b95b06992e8332b7207f3e2c91d55b7a4576805cc","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q94AF2.json","taxon_id":"3702","uniprot_accession":"Q94AF2","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/atp-dependent-nad-p-h-hydrate-dehydratase-activity-go0047453.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0047453","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/atp-dependent-nad-p-h-hydrate-dehydratase-activity-go0047453.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/b-subtilis-yxko-protein-of-unknown-function-and-related-proteins-based-cd01171.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd01171","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/b-subtilis-yxko-protein-of-unknown-function-and-related-proteins-based-cd01171.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/atp-adp-dependent-s-nad-p-h-hydrate-dehydratase-ipr000631.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR000631","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/atp-adp-dependent-s-nad-p-h-hydrate-dehydratase-ipr000631.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/ncbifam/nad-p-h-hydrate-dehydratase-tigr00196.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:TIGR00196","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/ncbifam/nad-p-h-hydrate-dehydratase-tigr00196.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/carb-kinase-pf01256.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF01256","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/carb-kinase-pf01256.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/profile/yjef-c-3.yaml","qualification_status":"NOT_ASSESSED","record_id":"PROSITE:PS51383","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/profile/yjef-c-3.yaml"}],"pfam_ids":["PF01256"],"protein_name":"ATP-dependent (S)-NAD(P)H-hydrate dehydratase","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAVHACGAAAAVVALLSAAIALQWSPLYAVLQRALSLHTAHATKDMENLFQLVRNIVPALTSKKHKGQDGRIGIVGGCQEYTGAPYFAGISALKVGADLTHVFCAREAAPVIKSYSPELIVHPVLDSSNAVEEVEKWLPRLHALVVGPGLGRDDLLLNNVRGILESTKARDIPVVIDADGLWLVAQQPALIHSYHKAILTPNHVEFSRLWEAVLSSPMDSNDLKGSTLKLSQALGNITVVQKGEQDLISNGQQVLVCNQEGSSRRCGGQGDLLSGSLGVMVHWALRAGPEKTNGSSPLLVAAWGACTLTRECNRQAFQKYGRSTTTTDMITEVGTAFSRLFTT","sequence_length":343,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"d5f7f6187577943a41b71da06dd07909426f9ce80131c426a26836feb8039e91","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9CZ42.json","taxon_id":"10090","uniprot_accession":"Q9CZ42","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Drosophila melanogaster","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/atp-dependent-nad-p-h-hydrate-dehydratase-activity-go0047453.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0047453","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/atp-dependent-nad-p-h-hydrate-dehydratase-activity-go0047453.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/conservation/interpro/carbohydrate-kinase-predicted-conserved-site-ipr017953.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR017953","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/conservation/interpro/carbohydrate-kinase-predicted-conserved-site-ipr017953.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/b-subtilis-yxko-protein-of-unknown-function-and-related-proteins-based-cd01171.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd01171","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/b-subtilis-yxko-protein-of-unknown-function-and-related-proteins-based-cd01171.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/atp-adp-dependent-s-nad-p-h-hydrate-dehydratase-ipr000631.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR000631","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/atp-adp-dependent-s-nad-p-h-hydrate-dehydratase-ipr000631.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/ncbifam/nad-p-h-hydrate-dehydratase-tigr00196.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:TIGR00196","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/ncbifam/nad-p-h-hydrate-dehydratase-tigr00196.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/profile/yjef-c-3.yaml","qualification_status":"NOT_ASSESSED","record_id":"PROSITE:PS51383","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/profile/yjef-c-3.yaml"}],"pfam_ids":["PF01256"],"protein_name":"ATP-dependent (S)-NAD(P)H-hydrate dehydratase","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAAVSDIPVHLPKLLALFKTVVPKLVNNKHKGQYGRIGVIGGSLEYTGAPYFAAISSIRVGADLAHVFCHSNASAIIKSYSPDLIVHPVLDCVDAVERIAPWLERLHVVVIGPGLGREPGILKTASNVLKLCMDTKKPVVIDADGLFLLNDNLNLICGQPNVILTPNVMEFQRLFGEDDQAARQKMSLLGAGVTVLEKGANDKIYLPHCNEVHSMPSGGSGRRCGGQGDLLSGSLATFFSWSLQSGEPNPALVAACASSYFVKKLNAAAFQKFGRSLLASDMVNQIPSVFQTEFENSDPQ","sequence_length":300,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"794c8bb287e6a97f5410fb4823c9a375202640aec2582da08cc0e0e189de53db","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9VVW8.json","taxon_id":"7227","uniprot_accession":"Q9VVW8","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/pattern/yjef-c-1.yaml","qualification_status":"NOT_ASSESSED","record_id":"PROSITE:PS01049","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/pattern/yjef-c-1.yaml"}],"pfam_ids":["PF01256","PF03853"],"protein_name":"Bifunctional NAD(P)H-hydrate repair enzyme Nnr","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKEIDELTIKEYGVDSRILMERAGISVVLAMEEELGNLSDYRFLVLCGGGNNGGDGFVVARNLLGVVKDVLVVFLGKKKTPDCEYNYGLYKKFGGKVVEQFEPSILNEFDVVVDAIFGTGLRGEITGEYAEIINLVNKSGKVVVSVDVPSGIDSNTGKVLRTAVKADLTVTFGVPKIGHILFPGRDLTGKLKVANIGHPVHLINSINRYVITREMVRSLLPERPRDSHKGTYGKVLIIAGSRLYSGAPVLSGMGSLKVGTGLVKLAVPFPQNLIATSRFPELISVPIDTEKGFFSLQNLQECLELSKDVDVVAIGPGLGNNEHVREFVNEFLKTLEKPAVIDADAINVLDTSVLKERKSPAVLTPHPGEMARLVKKTVGDVKYNYELAEEFAKENDCVLVLKSATTIVTDGEKTLFNITGNTGLSKGGSGDVLTGMIAGFIAQGLSPLEASTVSVYLHGFAAELFEQDERGLTASELLRLIPEAIRRLKE","sequence_length":490,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"c7c789fb3641bd50039ca89e7d84de7029d6a39903097f64742d15d5e55ab893","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9X024.json","taxon_id":"243274","uniprot_accession":"Q9X024","uniprot_release":"2026_03"}],"pfam_id":"PF01256","short_name":"Carb_kinase","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}