{"cross_mech":[],"family":{"alphafold_models":635,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This domain is found in the C terminus of N(4)-bis(aminopropyl)spermidine synthase ([ec:2.5.1.128], also known as Branched-chain polyamine synthase A, BpsA) from hyperthermophiles [[cite:PUB00074302]] and in uncharacterised proteins from bacteria and archaea.","domain_architectures":5,"interpro_id":"IPR002723","known_evidence_count":null,"matches":927,"name":"Branched-chain polyamine synthase A C-terminal domain","partial_evidence_count":null,"pfam_id":"PF01861","proteins":927,"proteomes":891,"short_name":"BpsA_C","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01861","structures":7,"taxa":1573,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF01861.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":635,"domain_architectures":5,"matches":927,"proteins":927,"proteomes":891,"structures":7,"taxa":1573},"curation_status":"SEEDED","description":"This domain is found in the C terminus of N(4)-bis(aminopropyl)spermidine synthase ([ec:2.5.1.128], also known as Branched-chain polyamine synthase A, BpsA) from hyperthermophiles [[cite:PUB00074302]] and in uncharacterised proteins from bacteria and archaea.","id":"Pfam:PF01861","interpro_id":"InterPro:IPR002723","name":"Branched-chain polyamine synthase A C-terminal domain","pfam_id":"PF01861","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"BpsA_C","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01861"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF01861.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"4a4328c5215190f467c45a78cb7ee2cb9870687413f319a2a7939ffc33ac8792"}},"protein_examples":{"candidate_count":4,"discovery_scanned":true,"example_count":4,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Thermus thermophilus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/bpsa-c-pf01861.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF01861","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/bpsa-c-pf01861.yaml"}],"pfam_ids":["PF01861"],"protein_name":"N(4)-bis(aminopropyl)spermidine synthase","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MNKEALVQVAEEVRRATGLPVGWRDVERTLGALRATRDLWEAVRLSRVPLRFLVPIWEGLARRGLLRVEEGLDLLAEVPAPRPGEAACPACEGRGLVGERLPGRAAERFLAWAKERPEAIQDFDQGYVTPESTLARVALAWNWGDLEGKEVLVLGDDDLTGLAAALTGLPKRVVVLDADPRIVRFLERAAKAEGLPLEAHVHDLREPLPEAWVHAFHTFFTDPVEGPLGLQAFVGRGLLALEGEGCAGYVGLTHVEASLAKWADFQRFLLENGAVITELRDGFHVYENWGYIEQMRAWPWLPVKRRPEKPWYTSALIRLELLRRADLENARVEGDLQDEEATY","sequence_length":343,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"6b93dc6be953848e6e23554b5d79db7b0f6604e2d5527e83e5baee8425401bf8","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P25125.json","taxon_id":"274","uniprot_accession":"P25125","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/n-4-bis-aminopropyl-spermidine-synthase-c-terminal-ipr002723.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR002723","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/n-4-bis-aminopropyl-spermidine-synthase-c-terminal-ipr002723.yaml"}],"pfam_ids":["PF01861"],"protein_name":"Uncharacterized protein MJ0675","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKIIGKIGKGKVEVNEKTKFSILLNNVAKKADIAEGKRAVEDIIRVIYRHQPISTKKIAQKTRLPLPIVAKVRTILEREKILKRTERGAELTDLGKEFAENFLKLKYKKSLTCKTCNGRGIVLDEFFEDILNKVRVWAKRRPLVDTTIDQSFATPETSTYRAALMYERGDLEGKRILFVGDDDLTSLPTALTNMAEEIAVVDIDERILKLIEKFSQKEGVKIKTIKHDLRNPLPQDLKERFDVISTDPPYTVDGLKLFLSRGIEALGKEGIAYLSYSHKPIDEWLSIQKAITNMGFVISELIPNFNYYEGSEIIANTTFIARLVGKNLKINIGDTEKIYTGLVKPVIRYYKCLKCGKIHKVGEEVKKVEDLVCECGGKKFKMIKREKLKNE","sequence_length":391,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"933441e5c8a43cd016f2e99d7d074284c12531aa014f027174233f135757cff4","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q58088.json","taxon_id":"243232","uniprot_accession":"Q58088","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/transferase-activity-transferring-alkyl-or-aryl-other-than-methyl-groups-go0016765.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0016765","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/transferase-activity-transferring-alkyl-or-aryl-other-than-methyl-groups-go0016765.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/polyamine-biosynthetic-process-go0006596.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0006596","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/polyamine-biosynthetic-process-go0006596.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/n-4-bis-aminopropyl-spermidine-synthase-c-terminal-ipr002723.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR002723","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/n-4-bis-aminopropyl-spermidine-synthase-c-terminal-ipr002723.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/bpsa-c-pf01861.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF01861","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/bpsa-c-pf01861.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q58669","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF01861"],"protein_name":"N(4)-bis(aminopropyl)spermidine synthase","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"04150bef0702f7ba70fa3e7ec63d8c23a5bb66322948950bdb3be23fa3607292","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MERILEKVRAKSEIPVYDKSIENVLSAILTTNDFWKIVDLSEEPLPLVADIIRILEEEGLVKISNGIEFTEKGNEFIKSYGIGAKDNSVCECCEGRGVSLKNYQDLLERFKEIVKNRPMPKHEYDQGFVTPECTISRIALMNSRGDLFNKDVLVLGDDDLTSIALMLSNLPKKIVVVDIDDRLINFIKEVAEQLNYKNIEVITLDLRKPLPEKYSRAFDTFITDPPETVYAVKTFIGRGISALKGERRAGYFGITRRESSLDKWREIQRTLINDFNVVITDIIRNFNHYVNWGYEEETRAWKLAPVKKKPEDIWYKSYMFRIETLKDSRGFEEEVDVGDELYNDAESSTT","sequence_length":350,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"04150bef0702f7ba70fa3e7ec63d8c23a5bb66322948950bdb3be23fa3607292","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q58669.json","taxon_id":"243232","uniprot_accession":"Q58669","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/bpsa-c-pf01861.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF01861","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/bpsa-c-pf01861.yaml"}],"pfam_ids":["PF01861"],"protein_name":"N(4)-bis(aminopropyl)spermidine synthase","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MREIIERVKEKTTIPVYERTIENVLSAIQASGDVWRIVDLSEEPLPLVVAVVTALYELGYVAFENNQVILTRKGKELVEKYGIGPRADYTCSHCQGRTVEIDAFSELLEQFKEITRDRPEPAHQFDQAYVTPETTVARVALMHSRGDLENKEVFVLGDDDLTSVALMLSGLPKRIAVLDIDERLTKFIEKAADEIGYENIEIFTFDLRKPLPDYALHKFDTFITDPPETVEAIRAFVGRGIATLKGPGCAGYFGITRRESSLDKWREIQRVLLNEFGVVITDIIRNFNEYVNWGYVEETRAWRLLPIKVKPSYNWYKSYMFRIQTLEGSKGFEDEITVGQELYDDEESSTT","sequence_length":351,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"5635ccd8de315c46fddc15398468b045546069c307f7901566bacfc815898278","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q5JIZ3.json","taxon_id":"69014","uniprot_accession":"Q5JIZ3","uniprot_release":"2026_03"}],"pfam_id":"PF01861","short_name":"BpsA_C","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
