{"cross_mech":[],"family":{"alphafold_models":1034,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"PH1010 [swissprot:O58738] is composed of five alpha-helices (1-5) and eight beta-strands (1-8) with the following topology: beta-1, alpha-1, beta-2, beta-3, alpha-2, alpha-3, beta-4, beta-5, alpha-4, beta-6, alpha-5, beta-7, beta-8. The first six beta-strands (1-6) form a slightly twisted antiparallel beta-sheet and face five alpha-helices on one side. The last two beta-strands form an antiparallel beta-sheet in the C-terminus. PH1010 forms a characteristic homodimer structure in the crystal. Dimerisation of the molecule is crucial for function. The structure resembles that of some ribosomal proteins such as the 50S ribosomal protein L5 [[cite:PUB00051274]]. Although the structure resembles that of the RRM-type RNA-binding domain of the ribosomal L5 protein, the residues involved in RNA-binding in the L5 protein are not conserved in this family [[cite:PUB00048377]]. Despite this, these proteins bind to double-stranded RNA in a non-sequence specific manner [[cite:PUB00066786]].","domain_architectures":2,"interpro_id":"IPR002739","known_evidence_count":null,"matches":1082,"name":"RNA binding","partial_evidence_count":null,"pfam_id":"PF01877","proteins":1082,"proteomes":562,"short_name":"RNA_binding","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01877","structures":7,"taxa":1009,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF01877.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1034,"domain_architectures":2,"matches":1082,"proteins":1082,"proteomes":562,"structures":7,"taxa":1009},"curation_status":"SEEDED","description":"PH1010 [swissprot:O58738] is composed of five alpha-helices (1-5) and eight beta-strands (1-8) with the following topology: beta-1, alpha-1, beta-2, beta-3, alpha-2, alpha-3, beta-4, beta-5, alpha-4, beta-6, alpha-5, beta-7, beta-8. The first six beta-strands (1-6) form a slightly twisted antiparallel beta-sheet and face five alpha-helices on one side. The last two beta-strands form an antiparallel beta-sheet in the C-terminus. PH1010 forms a characteristic homodimer structure in the crystal. Dimerisation of the molecule is crucial for function. The structure resembles that of some ribosomal proteins such as the 50S ribosomal protein L5 [[cite:PUB00051274]]. Although the structure resembles that of the RRM-type RNA-binding domain of the ribosomal L5 protein, the residues involved in RNA-binding in the L5 protein are not conserved in this family [[cite:PUB00048377]]. Despite this, these proteins bind to double-stranded RNA in a non-sequence specific manner [[cite:PUB00066786]].","id":"Pfam:PF01877","interpro_id":"InterPro:IPR002739","name":"RNA binding","pfam_id":"PF01877","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"RNA_binding","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01877"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF01877.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"cb38ea114a790910b0b82abb4e30d6cbfa9e2f50b551d53804f93fbd925a2c91"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/rna-binding-pf01877.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF01877","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/rna-binding-pf01877.yaml"}],"pfam_ids":["PF01877"],"protein_name":"Uncharacterized protein MJ0213","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MLNSIKLSAIVHATEDEDKVLEAIEFFIPENVDEEKIDLDVVETQGYFGNPIKIINVNVEGKEAKKIFKHIIDLIKSDDKNINKLKKDLHLRVEDNKFYVRFDKQKAYLGECRVVDGDDIIRAVFNFKIFTPKNKEEKVKEIVANELGF","sequence_length":149,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"08976110e20e97a245bfab25f140ba8b194e516c9039d4ad511e4b4edc4df606","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q57666.json","taxon_id":"243232","uniprot_accession":"Q57666","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/rna-binding-pf01877.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF01877","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/rna-binding-pf01877.yaml"}],"pfam_ids":["PF01877"],"protein_name":"UPF0201 protein MJ1564","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MEVIIKAKVKPTEDKYKVKKAILNIFPKAKLTFIEKDNEFGEWEGKTKSVEKLKELLRSQSILDAARMVLEKGMTENATKFYLNKQAAYVGAVNFDIDTHGGIFVKILADENEDIMKIIKDIAPRTKGGVIINEDELEEEEEKEDSEEIKEGHKEENNLKIKVIDNSSGD","sequence_length":170,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"bebb16162bdeb79a3b54b6d9d5f8e7bb433a2f8fcaaa057b742efca843aa5930","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q58959.json","taxon_id":"243232","uniprot_accession":"Q58959","uniprot_release":"2026_03"}],"pfam_id":"PF01877","short_name":"RNA_binding","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}