{"cross_mech":[],"family":{"alphafold_models":3211,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This is a family of proteins, previously known as DUF62, found in archaebacteria and bacteria. The structure of proteins in this family is similar to that of a bacterial fluorinating enzyme [[cite:PUB00047427]]. S-adenosyl-l-methionine hydroxide adenosyltransferases utilises a rigorously conserved amino acid side chain triad (Asp-Arg-His) which may have a role in activating water to hydroxide ion [[cite:PUB00054078]]. This family used to be known as DUF62.","domain_architectures":11,"interpro_id":"IPR046469","known_evidence_count":null,"matches":4632,"name":"SAM hydroxide adenosyltransferase N-terminal domain","partial_evidence_count":null,"pfam_id":"PF01887","proteins":4611,"proteomes":4378,"short_name":"SAM_HAT_N","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01887","structures":33,"taxa":7070,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF01887.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":3211,"domain_architectures":11,"matches":4632,"proteins":4611,"proteomes":4378,"structures":33,"taxa":7070},"curation_status":"SEEDED","description":"This is a family of proteins, previously known as DUF62, found in archaebacteria and bacteria. The structure of proteins in this family is similar to that of a bacterial fluorinating enzyme [[cite:PUB00047427]]. S-adenosyl-l-methionine hydroxide adenosyltransferases utilises a rigorously conserved amino acid side chain triad (Asp-Arg-His) which may have a role in activating water to hydroxide ion [[cite:PUB00054078]]. This family used to be known as DUF62.","id":"Pfam:PF01887","interpro_id":"InterPro:IPR046469","name":"SAM hydroxide adenosyltransferase N-terminal domain","pfam_id":"PF01887","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"SAM_HAT_N","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01887"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF01887.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"f1d3b64cbf550bf1be9c2fa25d46e2b6f5b22721b5597f3d024482ac5d12623e"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / JCM 13857 / NBRC 105044 / CNB-440)","origins":[{"cited_uniprot_accession":"A4X3Q0","commit":"e66f934111777c4ebfe69475d0520c0cfa074785","link_basis":["uniprot_pfam_xref"],"mech":"NaturalProductMech","path":"data/natural_products/amino_acids_and_peptides/salinosporamide-a.yaml","qualification_status":"NOT_ASSESSED","record_id":"CHEBI:48045","section":"uniprot_accession","url":"https://github.com/CultureBotAI/NaturalProductMech/blob/e66f934111777c4ebfe69475d0520c0cfa074785/data/natural_products/amino_acids_and_peptides/salinosporamide-a.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:A4X3Q0","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF01887","PF20257"],"protein_name":"Adenosyl-chloride synthase","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"8f8f4b2914c6a632f54add3a55e93e15b6b7987200bef36f7cc83d7bfa5e79cd","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MQHNLIAFLSDVGSADEAHALCKGVMYGVAPAATIVDITHDVAPFDVREGALFLADVPHSFPAHTVICAYVYPETGTATHTIAVRNEKGQLLVGPNNGLLSFALDASPAVECHEVLSPDVMNQPVTPTWYGKDIVAACAAHLAAGTDLAAVGPRIDPKQIVRLPYASASEVEGGIRGEVVRIDRAFGNVWTNIPTHLIGSMLQDGERLEVKIEALSDTVLELPFCKTFGEVDEGQPLLYLNSRGRLALGLNQSNFIEKWPVVPGDSITVSPRVPDSNLGPVLG","sequence_length":283,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"8f8f4b2914c6a632f54add3a55e93e15b6b7987200bef36f7cc83d7bfa5e79cd","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/A4X3Q0.json","taxon_id":"369723","uniprot_accession":"A4X3Q0","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/s-adenosyl-l-methionine-hydroxide-adenosyltransferase-c-terminal-domai-ipr046470.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR046470","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/s-adenosyl-l-methionine-hydroxide-adenosyltransferase-c-terminal-domai-ipr046470.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/s-adenosyl-l-methionine-hydroxide-adenosyltransferase-n-terminal-domai-ipr046469.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR046469","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/s-adenosyl-l-methionine-hydroxide-adenosyltransferase-n-terminal-domai-ipr046469.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/sam-hat-c-pf20257.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF20257","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/sam-hat-c-pf20257.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/sam-hat-n-pf01887.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF01887","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/sam-hat-n-pf01887.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/s-adenosyl-l-methionine-hydroxide-adenosyltransferase-c-terminal-domai-ipr023227.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR023227","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/s-adenosyl-l-methionine-hydroxide-adenosyltransferase-c-terminal-domai-ipr023227.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/s-adenosyl-l-methionine-hydroxide-adenosyltransferase-n-terminal-domai-ipr023228.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR023228","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/s-adenosyl-l-methionine-hydroxide-adenosyltransferase-n-terminal-domai-ipr023228.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/bacterial-fluorinating-enzyme-like-2-40-30-90.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:2.40.30.90","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/bacterial-fluorinating-enzyme-like-2-40-30-90.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/s-adenosyl-l-methionine-hydroxide-adenosyltransferase-n-terminal-3-40-50-10790.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:3.40.50.10790","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/s-adenosyl-l-methionine-hydroxide-adenosyltransferase-n-terminal-3-40-50-10790.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q59045","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF01887","PF20257"],"protein_name":"(R)-S-adenosyl-L-methionine hydrolase","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"b11d16a13ba438b5563245abf3628986e1cb3194f8cfb47d9434091a35b47640","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MGIYMRDDILDIITLTTDFGTNEGYVGAMKGRILNILKKYNKDAKIIDISHEIKPFNIYHGAYVLLTAIPYFPPSVHVAVIDPTVGSERKSIVIETKSGYYLVGPDNGLFTYVAEKLGIKRIIKIDEERYKPSSTFHGRDVYAVVGAEILINNGYDGEELDEMVKIDETKKRVIHIDRFGNIITNIKKDEVTFKYYDTIMIKIRHKNGIEKIIKCKFVKSYFEEKNNFICLINSEGFLEISKFMDNASKLLNVDYLDEIEIIY","sequence_length":263,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"b11d16a13ba438b5563245abf3628986e1cb3194f8cfb47d9434091a35b47640","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q59045.json","taxon_id":"243232","uniprot_accession":"Q59045","uniprot_release":"2026_03"}],"pfam_id":"PF01887","short_name":"SAM_HAT_N","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
