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This enzyme is characterised so far in Methanocaldococcus jannaschii (Methanococcus jannaschii) [[cite:PUB00013496]] but appears restricted to F420-containing species and is predicted to carry out the same function in these other species. CofD monomer contains 12 beta- strands, seven of them form a Rossmann fold, and 13 alpha-helices [[cite:PUB00050875]].","domain_architectures":45,"interpro_id":"IPR002882","known_evidence_count":null,"matches":14214,"name":"2-phospho-L-lactate transferase CofD","partial_evidence_count":null,"pfam_id":"PF01933","proteins":14174,"proteomes":10830,"short_name":"CofD","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01933","structures":13,"taxa":17069,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF01933.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":9318,"domain_architectures":45,"matches":14214,"proteins":14174,"proteomes":10830,"structures":13,"taxa":17069},"curation_status":"SEEDED","description":"This entry contains 2-phospho-L-lactate transferase (CofD), phosphoenolpyruvate transferase and related sequences. CofD catalyses the fourth step in the biosynthesis of coenzyme F420, which is the transfer of the 2-phospholactate moiety from lactyl (2)diphospho-(5') guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of the L-lactyl phosphodiester of 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (F420-0) and GMP. F420 is a flavin derivative found in methanogens, Mycobacteria, and several other lineages. This enzyme is characterised so far in Methanocaldococcus jannaschii (Methanococcus jannaschii) [[cite:PUB00013496]] but appears restricted to F420-containing species and is predicted to carry out the same function in these other species. CofD monomer contains 12 beta- strands, seven of them form a Rossmann fold, and 13 alpha-helices [[cite:PUB00050875]].","id":"Pfam:PF01933","interpro_id":"InterPro:IPR002882","name":"2-phospho-L-lactate transferase 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