{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF01940","protein_label":"Protein VTE6, chloroplastic","reviewed":true,"short_name":"DUF92","source_category":"function/molecular_function/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/molecular_function/go/phytol-kinase-activity-go0010276.yaml","source_record_id":"GO:0010276","source_record_label":"phytol kinase activity","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9SYM0","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF01940","protein_label":"Protein VTE6, chloroplastic","reviewed":true,"short_name":"DUF92","source_category":"function/molecular_function/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/molecular_function/go/phytyl-p-kinase-activity-go0102763.yaml","source_record_id":"GO:0102763","source_record_label":"phytyl-P kinase activity","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9SYM0","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF01940","protein_label":"Protein VTE6, chloroplastic","reviewed":true,"short_name":"DUF92","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/phytol-metabolic-process-go0033306.yaml","source_record_id":"GO:0033306","source_record_label":"phytol metabolic process","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9SYM0","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF01940","protein_label":"Protein VTE6, chloroplastic","reviewed":true,"short_name":"DUF92","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/vitamin-e-biosynthetic-process-go0010189.yaml","source_record_id":"GO:0010189","source_record_label":"vitamin E biosynthetic process","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9SYM0","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF01940","protein_label":"Protein VTE6, chloroplastic","reviewed":true,"short_name":"DUF92","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/vitamin-k-biosynthetic-process-go0042371.yaml","source_record_id":"GO:0042371","source_record_label":"vitamin K biosynthetic process","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9SYM0","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF01940","protein_label":"Uncharacterized membrane protein MJ0933","reviewed":true,"short_name":"DUF92","source_category":"function/protein_family/ncbifam","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/protein_family/ncbifam/tigr00297-family-protein-tigr00297.yaml","source_record_id":"NCBIfam:TIGR00297","source_record_label":"TIGR00297 family protein","source_section":"canonical_examples","taxon_id":"NCBITaxon:243232","taxon_label":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","uniprot_accession":"Q58343","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF01940","protein_label":"Protein PGR","reviewed":true,"short_name":"DUF92","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf92-pf01940.yaml","source_record_id":"Pfam:PF01940","source_record_label":"Integral membrane protein DUF92","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q0WP96","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF01940","protein_label":"Transmembrane protein 19","reviewed":true,"short_name":"DUF92","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf92-pf01940.yaml","source_record_id":"Pfam:PF01940","source_record_label":"Integral membrane protein DUF92","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q96HH6","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF01940","protein_label":"Protein VTE6, chloroplastic","reviewed":true,"short_name":"DUF92","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf92-pf01940.yaml","source_record_id":"Pfam:PF01940","source_record_label":"Integral membrane protein DUF92","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9SYM0","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF01940","protein_label":"","reviewed":null,"short_name":"DUF92","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf92-pf01940.yaml","source_record_id":"Pfam:PF01940","source_record_label":"Integral membrane protein DUF92","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"KNOWN_HISTORICAL_DUF"}],"family":{"alphafold_models":4924,"candidate_reasons":["short_name_matches_duf"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":4,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":7},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"Members of this family have several predicted transmembrane helices. One member of the family has been characterised as protein PGR (AtPGR). PGR is suggested to be a potential glucose-responsive regulator in carbohydrate metabolism in plants. This entry also includes protein VTE6, which is a Pphytyl-phosphate kinase catalysing the conversion of phytyl-monophosphate to phytyl-diphosphate [[cite:PUB00092523]].","domain_architectures":97,"interpro_id":"IPR002794","known_evidence_count":null,"matches":6228,"name":"Integral membrane protein DUF92","partial_evidence_count":null,"pfam_id":"PF01940","proteins":6136,"proteomes":4750,"short_name":"DUF92","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01940","structures":0,"taxa":11004,"unknown_status":"KNOWN_HISTORICAL_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF01940.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":4924,"domain_architectures":97,"matches":6228,"proteins":6136,"proteomes":4750,"structures":0,"taxa":11004},"curation_status":"SEEDED","description":"Members of this family have several predicted transmembrane helices. One member of the family has been characterised as protein PGR (AtPGR). PGR is suggested to be a potential glucose-responsive regulator in carbohydrate metabolism in plants. This entry also includes protein VTE6, which is a Pphytyl-phosphate kinase catalysing the conversion of phytyl-monophosphate to phytyl-diphosphate [[cite:PUB00092523]].","id":"Pfam:PF01940","interpro_id":"InterPro:IPR002794","name":"Integral membrane protein DUF92","pfam_id":"PF01940","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"KNOWN_HISTORICAL_DUF","short_name":"DUF92","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01940"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF01940.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"8571d11c1d37eed3d34923e466be5177e0509375e049e18f89f23b93b1b21bb0"}},"protein_examples":{"candidate_count":4,"discovery_scanned":true,"example_count":4,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Arabidopsis thaliana","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf92-pf01940.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF01940","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf92-pf01940.yaml"}],"pfam_ids":["PF01940"],"protein_name":"Protein PGR","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"METSPQFRLIFAVIISSLIAFRSYKRKSLDLSGGIAGFLVMTIHFTAGFRYGALLLVFFLTSSKLTKVGEDKKRRVDVEFKEGGQRNWVQVLCNSGIASVLVVIACTLTGWKDKCLDSKQSEIVTALIGGIIGHYACCNGDTWSSELGVLSDAQPRLITTFKPVKKGTNGGVTKAGLLAALAAGTTVGLTFLIFGLFTASCASDVALKQLLVIPLSALAGLCGSLIDSILGATIQFSGFCSVRNKVVGKPGPTVKKISGVDILDNNGVNFVSILLTSFLTSIASVYIF","sequence_length":288,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"f6580358650221e2f4417db891c1cc4ae8f5320eaed7837742111b3edfd46ddf","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q0WP96.json","taxon_id":"3702","uniprot_accession":"Q0WP96","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/protein_family/ncbifam/tigr00297-family-protein-tigr00297.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:TIGR00297","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/protein_family/ncbifam/tigr00297-family-protein-tigr00297.yaml"}],"pfam_ids":["PF01940"],"protein_name":"Uncharacterized membrane protein MJ0933","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MEVDTMETLIRLFVSILIICVLALMIKKSRCLDNEGVIGSSIMGFILLYFCGFKYLILLLSFFILGVLVSRVGLEKKKAKKMDETCRSLKNVLANGLIPILFAILAIFGFNWALIGYISSIAAATSDTFSSELGILSNEKPRLITTFEVVEKGTDGAITIFGTLAGVLGAFLIGLFGYLLFGDIKIVLCGTAGGIAGNLADSLVGALFERKGILNNEHVNLIATIVGGIIGVLIYCTL","sequence_length":238,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"bb7f6018ff9f840772dbaeb6ef1608a02080fac4510d1b29d8d95cbef8b52b37","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q58343.json","taxon_id":"243232","uniprot_accession":"Q58343","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf92-pf01940.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF01940","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf92-pf01940.yaml"}],"pfam_ids":["PF01940"],"protein_name":"Transmembrane protein 19","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTDLNDNICKRYIKMITNIVILSLIICISLAFWIISMTASTYYGNLRPISPWRWLFSVVVPVLIVSNGLKKKSLDHSGALGGLVVGFILTIANFSFFTSLLMFFLSSSKLTKWKGEVKKRLDSEYKEGGQRNWVQVFCNGAVPTELALLYMIENGPGEIPVDFSKQYSASWMCLSLLAALACSAGDTWASEVGPVLSKSSPRLITTWEKVPVGTNGGVTVVGLVSSLLGGTFVGIAYFLTQLIFVNDLDISAPQWPIIAFGGLAGLLGSIVDSYLGATMQYTGLDESTGMVVNSPTNKARHIAGKPILDNNAVNLFSSVLIALLLPTAAWGFWPRG","sequence_length":336,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"70c74bedf1b9e50414881342cc5db52b5e5dbb3f62eab9670dce9434b1212a9d","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q96HH6.json","taxon_id":"9606","uniprot_accession":"Q96HH6","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Arabidopsis thaliana","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/phytol-kinase-activity-go0010276.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0010276","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/phytol-kinase-activity-go0010276.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/phytyl-p-kinase-activity-go0102763.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0102763","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/phytyl-p-kinase-activity-go0102763.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/phytol-metabolic-process-go0033306.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0033306","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/phytol-metabolic-process-go0033306.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/vitamin-e-biosynthetic-process-go0010189.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0010189","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/vitamin-e-biosynthetic-process-go0010189.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/vitamin-k-biosynthetic-process-go0042371.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0042371","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/vitamin-k-biosynthetic-process-go0042371.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf92-pf01940.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF01940","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf92-pf01940.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q9SYM0","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF01940"],"protein_name":"Protein VTE6, chloroplastic","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"fd3ce8a7dd706474883845d523e801b5a68e9806e12d9deb4b305bda3198409a","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MATISSTLLLNSSRSALPLRFPKFSGFSSSSPFARSYRFGRRNLEPLSNGMLSSGSRADGATAAAASMEGVMTEAMKLIQSASPTWKSAVANNLLIFVLGSPLLVTGLSASGIAAAFLLGTLTWRAYGSAGFLLVAAYFVIGTAATKVKMTQKEAQGVAEKRKGRRGPRSVIGSSAAGCVCAFLSIYQVGGAAFSQLFRLGFVSSFCTKVSDTVSSEIGKAYGKTTYLATTFKIVPRGTEGAMSLEGTLAGLLASFFLASVGCFLGQITPPEAAVCVLASQIANLGESIIGASFQDKEGFKWLNNDVVNVINISLGSIVAILMQQFILQNWVK","sequence_length":333,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"fd3ce8a7dd706474883845d523e801b5a68e9806e12d9deb4b305bda3198409a","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9SYM0.json","taxon_id":"3702","uniprot_accession":"Q9SYM0","uniprot_release":"2026_03"}],"pfam_id":"PF01940","short_name":"DUF92","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
