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TctA is a large transmembrane protein with up to 12 predicted membrane spanning regions in bacteria and up to 11 such in archaea, with the N-terminal within the cytoplasm. TctA is thought to be a permease, and in most other bacteria functions without TctB and TctC molecules [[cite:PUB00106923]].","domain_architectures":22,"interpro_id":"IPR002823","known_evidence_count":null,"matches":18244,"name":"Tripartite tricarboxylate transporter TctA family","partial_evidence_count":null,"pfam_id":"PF01970","proteins":18234,"proteomes":7121,"short_name":"TctA","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01970","structures":0,"taxa":9990,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF01970.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":11882,"domain_architectures":22,"matches":18244,"proteins":18234,"proteomes":7121,"structures":0,"taxa":9990},"curation_status":"SEEDED","description":"This family, formerly known as DUF112, is a family of bacterial and archaeal tripartite tricarboxylate transporters of the extracytoplasmic solute binding receptor-dependent transporter group of families, distinct from the ABC and TRAP-T families [[cite:PUB00106923]]. TctA is part of the tripartite TctABC system which, as characterised in S. typhimurium [[cite:PUB00106922]], is a secondary carrier that depends for activity on the extracytoplasmic tricarboxylate-binding receptor TctC as well as two integral membrane proteins, TctA and TctB. complete three-component systems are found only in bacteria. TctA is a large transmembrane protein with up to 12 predicted membrane spanning regions in bacteria and up to 11 such in archaea, with the N-terminal within the cytoplasm. TctA is thought to be a permease, and in most other bacteria functions without TctB and TctC molecules [[cite:PUB00106923]].","id":"Pfam:PF01970","interpro_id":"InterPro:IPR002823","name":"Tripartite tricarboxylate transporter TctA family","pfam_id":"PF01970","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"TctA","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01970"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF01970.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"40455b00cfd94f5ec5280e18a700218a0b93d9ab3be60f4332e15ce0ed215534"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/protein-of-unknown-function-duf112-transmembrane-ipr002823.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR002823","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/protein-of-unknown-function-duf112-transmembrane-ipr002823.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/tcta-pf01970.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF01970","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/tcta-pf01970.yaml"}],"pfam_ids":["PF01970"],"protein_name":"Uncharacterized protein MJ1079","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MLNLLYLILGIICGTITGLFPGIHPNNIVALSFLILPYFGLDNYIPFLIGLVITHYFINFIPSAFLGVPDDETAVSALPMHKLTLNGNGYEAIVLAGFGSYLGVVFSILISLFLMSILHFDVRAFYCSIKIFIPFILIAFILYQIFTAKSVWEVLVIFLSGIFGIAVLYCSEAFNITLTAIFTGMFGIPLLINNLKTYKIKSQMMAFPDFELKFLKSSFFASVAGFFRIFLPGISGAQLNYILSKILNERDLKNFIVSQGSIILSNEVFSLLAVIFIGVGRSGVARAIQLLNANININTAIFSILISSTIAIIILLNLSKYILLFIRKVNFKFLSLFFIIFCSLVVIIGSYNTYLIYHIIVYLTAIYIGLLAVKSNTNLSNMMNVLIFPTILYFLRG","sequence_length":397,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"ac23523008ba94887ec499ae1725dde1d6f35a8c0c306dd65d6b1f01f08ad798","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q58479.json","taxon_id":"243232","uniprot_accession":"Q58479","uniprot_release":"2026_03"}],"pfam_id":"PF01970","short_name":"TctA","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}