{"cross_mech":[],"family":{"alphafold_models":6625,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"One member of this family, TrmB, has been shown to be a sugar-specific transcriptional regulator of the trehalose/maltose ABC transporter [[cite:PUB00015607]] in Thermococcus litoralis.","domain_architectures":86,"interpro_id":"IPR002831","known_evidence_count":null,"matches":8670,"name":"Sugar-specific transcriptional regulator TrmB","partial_evidence_count":null,"pfam_id":"PF01978","proteins":8669,"proteomes":3373,"short_name":"TrmB","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01978","structures":15,"taxa":5343,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF01978.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":6625,"domain_architectures":86,"matches":8670,"proteins":8669,"proteomes":3373,"structures":15,"taxa":5343},"curation_status":"SEEDED","description":"One member of this family, TrmB, has been shown to be a sugar-specific transcriptional regulator of the trehalose/maltose ABC transporter [[cite:PUB00015607]] in Thermococcus litoralis.","id":"Pfam:PF01978","interpro_id":"InterPro:IPR002831","name":"Sugar-specific transcriptional regulator TrmB","pfam_id":"PF01978","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"TrmB","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01978"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF01978.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"18908add5bdaff36d0ce189c1c6707057ea96296a855be79824c79e87b8df155"}},"protein_examples":{"candidate_count":4,"discovery_scanned":true,"example_count":4,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Bacillus subtilis (strain 168)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/middle-phospholipase-d-like-domain-of-the-transcriptional-regulator-tr-cd09124.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd09124","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/middle-phospholipase-d-like-domain-of-the-transcriptional-regulator-tr-cd09124.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/transcription-regulator-trmb-c-terminal-ipr021586.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR021586","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/transcription-regulator-trmb-c-terminal-ipr021586.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/transcription-regulator-trmb-n-terminal-ipr002831.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR002831","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/transcription-regulator-trmb-n-terminal-ipr002831.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/trmb-ebd-n-pf11495.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF11495","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/trmb-ebd-n-pf11495.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/trmb-pf01978.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF01978","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/trmb-pf01978.yaml"}],"pfam_ids":["PF01978","PF11495"],"protein_name":"Uncharacterized protein YrhO","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKENMLDILKNLNFTEYESKAYLALLQESPLTGYAVAKKSGVPRSKIYEVLESLVIRGDVFVSHGNTPQYVPVPAKELIKNRRLKAEEHFDQAEKYFEKFEQTANDRENIWNITGRSEILEKVKACILSAKKRILLEIWKEDFKEIEAELKQAAEQGVIVTIIAYGDIVSDFANVYLHDMSSEITEEYDGRWLVYSGDDSEVVAGIVSLGNDSRAAWTMHVGLVMPITEVIIHDLYLMEILKKHRELLEESFGKNLIQLRRKFSIHSDFKKHYLE","sequence_length":275,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"41a4a73144218a152b13f5471611ee2699d1201b1dae2673010f1f0928bc26d0","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/O05405.json","taxon_id":"224308","uniprot_accession":"O05405","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/transcription-regulator-trmb-n-terminal-ipr002831.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR002831","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/transcription-regulator-trmb-n-terminal-ipr002831.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/trmb-pf01978.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF01978","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/trmb-pf01978.yaml"}],"pfam_ids":["PF01978"],"protein_name":"Uncharacterized protein MJ1082","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKEFIINRLKKFTIEDLMRCILGLQEIEIRVYFDLLENGEGSVLEIAERVNRDRTTVQKALRSLMNCGLVDRRKVTEKVGYKYIYNAVDLDRVSDIIEELLDDWYQNVKKWLTYFRENRK","sequence_length":120,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"9068313b11bfd041d18fe84069227ab665a4546e92cfc8f858b85bfc3d1bc3ec","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q58482.json","taxon_id":"243232","uniprot_accession":"Q58482","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/transcription-regulator-trmb-n-terminal-ipr002831.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR002831","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/transcription-regulator-trmb-n-terminal-ipr002831.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/trmb-pf01978.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF01978","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/trmb-pf01978.yaml"}],"pfam_ids":["PF01978"],"protein_name":"Uncharacterized protein MJ1503","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSKLLLKTPCTTWTFDSLMACVFGIKVSDVKVYFDILKNGPSKINDIAERINRDRSTVQRAVQNLMNAGLVKRKQVNIKDGGYYYVYEAIPFEETKKIIKKTMEEWCNNMKKWVEELEFEDVVKEYLENIEE","sequence_length":132,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"53cb5a279ddc3e47006f26cbb5e5167b1243007dd9bb4de38601313a42bd91f1","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q58898.json","taxon_id":"243232","uniprot_accession":"Q58898","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/fist-c-domain-ipr019494.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR019494","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/fist-c-domain-ipr019494.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/fist-domain-n-terminal-ipr013702.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR013702","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/fist-domain-n-terminal-ipr013702.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/transcription-regulator-trmb-n-terminal-ipr002831.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR002831","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/transcription-regulator-trmb-n-terminal-ipr002831.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/trmb-pf01978.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF01978","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/trmb-pf01978.yaml"}],"pfam_ids":["PF01978","PF08495","PF10442"],"protein_name":"Uncharacterized protein MJ1623","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MIYIHKKIKNPIKDGIEIGEEIKRNVGRASLIIFITSILERDKLKQVFDGMKQHIPLDNLIGCSTGGTFSGKDYIKEDGVLILAFDEYYKSAISCEKVDREAEYVGKKIADKIKTCIRDKYPKLDIDDNFLGFVFFDWNVDSEQEILDVLGRELTIPIIGGTAADDGSFDKFFQIYKGEVVKDCCVFGVVGGKLKFDLIYGHGYEPTDIYARVTKAEGKVVYELDGKPAYQRYLEMLSEYTKLPMDIIKKYFYRDLRRLDFYLVHPLGFMDINGNYITAFLERVEENTLVFRRDILEGSFLVLMKTDIEKQVKSIVDELKKAEDFENPLIFINECYGREVLKNSMFREFEEDILKYFLNFYKAGKKVEEYVIEDNCIGWLSYGETIAKDLIRFHNNLSFTGVIFELSQSSNINWREELKNFNFEDDEIEVIVNLINKQLTAKELLQLTNLSQTKLYHILNKLEKEGIIKSVSGKPKLYYIDNIKEILQKTHEKIEHENMVKKIKRKKLLRLL","sequence_length":512,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"982b84ce79fdb8a554c2fbd87b3468095668d29fd6c6e5f560841a1cf14867f1","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q59017.json","taxon_id":"243232","uniprot_accession":"Q59017","uniprot_release":"2026_03"}],"pfam_id":"PF01978","short_name":"TrmB","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
