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It is involved in the archaea; mevalonate (MVA) pathway, which provides fundamental precursos for isoprenoid biosynthesis such as isopentenyl diphosphate (IPP) and dimenthylallyl diphosphate (DMAPP) [[cite:PUB00098043],[cite:PUB00154970]]. This domain is also found at the N-terminal end of Cis-3-hydroxy-L-proline dehydratase from Agrobacterium fabrum (LhpI), which catalyses the dehydration of cis-3-hydroxy-L-proline (c3LHyp) to Delta1-pyrroline-2- carboxylate (Pyr2C) [[cite:PUB00088769]].","domain_architectures":22,"interpro_id":"IPR002840","known_evidence_count":null,"matches":2019,"name":"Aconitase X swivel domain","partial_evidence_count":null,"pfam_id":"PF01989","proteins":2019,"proteomes":1838,"short_name":"AcnX_swivel_put","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01989","structures":6,"taxa":3213,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF01989.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1449,"domain_architectures":22,"matches":2019,"proteins":2019,"proteomes":1838,"structures":6,"taxa":3213},"curation_status":"SEEDED","description":"This entry represents a domain centrally found in Phosphomevalonate dehydratase small subunit from Aeropyrum pernix (PMDh-S) and similar prokaryotic proteins previously annotated as aconitase X subunit 2, the swiveling domain subunit [[cite:PUB00080857]]. PMDh-S is a component of a hydro-lyase that catalyses the dehydration of mevalonate 5-phosphate (MVA5P) to form trans- anhydromevalonate 5-phosphate (tAHMP) [[cite:PUB00098043],[cite:PUB00154971]]. It is involved in the archaea; mevalonate (MVA) pathway, which provides fundamental precursos for isoprenoid biosynthesis such as isopentenyl diphosphate (IPP) and dimenthylallyl diphosphate (DMAPP) [[cite:PUB00098043],[cite:PUB00154970]]. This domain is also found at the N-terminal end of Cis-3-hydroxy-L-proline dehydratase from Agrobacterium fabrum (LhpI), which catalyses the dehydration of cis-3-hydroxy-L-proline (c3LHyp) to Delta1-pyrroline-2- carboxylate (Pyr2C) [[cite:PUB00088769]].","id":"Pfam:PF01989","interpro_id":"InterPro:IPR002840","name":"Aconitase X swivel 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dehydratase small 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