{"cross_mech":[],"family":{"alphafold_models":541,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family of archaeal proteins includes pantothenate synthetase from Methanosarcina mazei and 4-phosphopantoate--beta-alanine ligase (phosphopantothenate synthetase) from Pyrococcus kodakaraensis. Pantothenate synthetase catalyses the condensation of pantoate with beta-alanine in an ATP-dependent and ADP-producing reaction [[cite:PUB00066834]]. 4-phosphopantoate--beta-alanine ligase catalyses the conversion of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway. It cannot use (R)-pantoate as substrate and thus does not display pantothenate synthetase activity [[cite:PUB00060435]].","domain_architectures":1,"interpro_id":"IPR002855","known_evidence_count":null,"matches":578,"name":"Phosphopantothenate/pantothenate synthetase","partial_evidence_count":null,"pfam_id":"PF02006","proteins":578,"proteomes":577,"short_name":"PPS_PS","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02006","structures":5,"taxa":1045,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF02006.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":541,"domain_architectures":1,"matches":578,"proteins":578,"proteomes":577,"structures":5,"taxa":1045},"curation_status":"SEEDED","description":"This family of archaeal proteins includes pantothenate synthetase from Methanosarcina mazei and 4-phosphopantoate--beta-alanine ligase (phosphopantothenate synthetase) from Pyrococcus kodakaraensis. Pantothenate synthetase catalyses the condensation of pantoate with beta-alanine in an ATP-dependent and ADP-producing reaction [[cite:PUB00066834]]. 4-phosphopantoate--beta-alanine ligase catalyses the conversion of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway. It cannot use (R)-pantoate as substrate and thus does not display pantothenate synthetase activity [[cite:PUB00060435]].","id":"Pfam:PF02006","interpro_id":"InterPro:IPR002855","name":"Phosphopantothenate/pantothenate synthetase","pfam_id":"PF02006","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"PPS_PS","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02006"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF02006.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"cf2df3765dea5ceb3ff8bfe03cee5a952c584a58793c3609ec7de0e196806d09"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/protein_family/ncbifam/4-phosphopantoate-beta-alanine-ligase-nf041123.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:NF041123","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/protein_family/ncbifam/4-phosphopantoate-beta-alanine-ligase-nf041123.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/protein_family/ncbifam/phosphopantothenate-pantothenate-synthetase-nf010324.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:NF010324","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/protein_family/ncbifam/phosphopantothenate-pantothenate-synthetase-nf010324.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/pps-ps-pf02006.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF02006","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/pps-ps-pf02006.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/phosphopantoate-pantothenate-synthetase-superfamily-ipr038138.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR038138","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/phosphopantoate-pantothenate-synthetase-superfamily-ipr038138.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/phosphopantoate-pantothenate-synthetase-3-40-50-12640.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:3.40.50.12640","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/phosphopantoate-pantothenate-synthetase-3-40-50-12640.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q57662","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF02006"],"protein_name":"4-phosphopantoate--beta-alanine ligase","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"ef74d943c0dff250e13f30734cb677a78110969e23c6826b633c962c9b98b555","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MLSVMRMQIPKTHPRYESLMKREKIIEALDKGILAKAGLIAHGRGETFDYLIGEKTAPIALEAIKAAAALLILAENPVISVNGNTVALAIDEVVELAKELNGKIEVNLFYRTKERELAIKRAFEEKFKDDIETGKIKILGIDDANKQIPNLDSLRGKVSEEGIFTADVVLVPLEDGDRAEALVNMGKKVIAIDLNPLSRTARKSTITIVDELTRAMPLLIKYVKEFKNKDREELLKIVEDFDNKKNLKDMIDYIAERLKNLSLDEL","sequence_length":266,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"ef74d943c0dff250e13f30734cb677a78110969e23c6826b633c962c9b98b555","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q57662.json","taxon_id":"243232","uniprot_accession":"Q57662","uniprot_release":"2026_03"}],"pfam_id":"PF02006","short_name":"PPS_PS","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}