{"cross_mech":[],"family":{"alphafold_models":1927,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This domain is found in proteins from nematodes, including SXP/RAL-2 family protein Ani s 5 (ANIS5) from Anisakis simplex, and comprises two conserved motifs: SXP1 and SXP2 [[cite:PUB00097764]]. Although the function of this domain is not clear, structural information from ANIS5 revealed an alpha helical arrangement with a Calmodulin-like fold. Functional studies indicates that ANIS5 can bind magnesium and calcium, suggesting that this domain plays a role in cation binding [[cite:PUB00097763]]. These proteins are interesting targets to develop control strategies against the diseases caused by parasites.","domain_architectures":50,"interpro_id":"IPR003677","known_evidence_count":null,"matches":2126,"name":"SXP/RAL-2 family protein Ani s 5-like, metal-binding domain","partial_evidence_count":null,"pfam_id":"PF02520","proteins":2048,"proteomes":94,"short_name":"ANIS5_cation-bd","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02520","structures":1,"taxa":232,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF02520.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1927,"domain_architectures":50,"matches":2126,"proteins":2048,"proteomes":94,"structures":1,"taxa":232},"curation_status":"SEEDED","description":"This domain is found in proteins from nematodes, including SXP/RAL-2 family protein Ani s 5 (ANIS5) from Anisakis simplex, and comprises two conserved motifs: SXP1 and SXP2 [[cite:PUB00097764]]. Although the function of this domain is not clear, structural information from ANIS5 revealed an alpha helical arrangement with a Calmodulin-like fold. Functional studies indicates that ANIS5 can bind magnesium and calcium, suggesting that this domain plays a role in cation binding [[cite:PUB00097763]]. These proteins are interesting targets to develop control strategies against the diseases caused by parasites.","id":"Pfam:PF02520","interpro_id":"InterPro:IPR003677","name":"SXP/RAL-2 family protein Ani s 5-like, metal-binding domain","pfam_id":"PF02520","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"ANIS5_cation-bd","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02520"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF02520.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"740bc6d71b1cbdf33b8414b69d43a1b9efb0aa176491ab0a9b557fe7d800c574"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Anisakis simplex","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/anis5-cation-bd-pf02520.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF02520","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/anis5-cation-bd-pf02520.yaml"}],"pfam_ids":["PF02520"],"protein_name":"SXP/RAL-2 family protein Ani s 5","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKTLIVAALFCTIGMALADDTPPPPPFLAGAPQDVVKAFFELLKKDETKTDPEIEKDLDAWVDTLGGDYKAKFETFKKEMKAKEAELAKAHEEAVAKMTPEAKKADAELSKIAEDDSLNGIQKAQKIQAIYKTLPQSVKDELEKGIGPAVPQ","sequence_length":152,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"e4e8598da2511ec8b55be4d9686adc30fa24c3c19bd5967bf07913ee639cd7ed","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/A1IKL2.json","taxon_id":"6269","uniprot_accession":"A1IKL2","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Onchocerca volvulus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/anis5-cation-bd-pf02520.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF02520","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/anis5-cation-bd-pf02520.yaml"}],"pfam_ids":["PF02520"],"protein_name":"OV-17 antigen","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKFVILLTIGLLVVAAIPQRRQQQQQQQQQQQRDEREIPPFLEGAPPSVIDEFYNLLKTDENKTDQQTEADVEAFINRLGGSYKVRFTQFMEEVKKARADYERIHQQAVARFSPAAKDADARMSAIADSPHLTTRQKSQQIQAIMDSLSESVRREIINALSPQE","sequence_length":164,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"57ccaad43d35ba040c80e8b0f55beece084ace614ad3644a120909a280aaddc0","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P36991.json","taxon_id":"6282","uniprot_accession":"P36991","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Caenorhabditis elegans","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/sxp-ral-2-family-protein-ani-s-5-like-cation-binding-domain-ipr003677.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR003677","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/sxp-ral-2-family-protein-ani-s-5-like-cation-binding-domain-ipr003677.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/anis5-cation-bd-pf02520.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF02520","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/anis5-cation-bd-pf02520.yaml"}],"pfam_ids":["PF02520"],"protein_name":"SXP/RAL-2-like protein 2","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAQNLLFCTIAFVFVAVAMAGPGGRGGPHGPGGHGPRGGPGLPPFLVNVTAAGRKEFEAVFKNETLTIAEANTQIAALAEKYGVTATYNEFVANRTALLAEVKKNQTAVIGNLTAVSAQLATIYQNKDQTRKAQEEAVDALRKEHPVEVNAIKFIRAQLGGEKVHGGSHGGLRGGPGGPRDGPRGGPRGGPRGGR","sequence_length":195,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"dffc0dc830324bbcff826295dcf2ecc4b039d316de2675206be0592ba05adfeb","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P50437.json","taxon_id":"6239","uniprot_accession":"P50437","uniprot_release":"2026_03"}],"pfam_id":"PF02520","short_name":"ANIS5_cation-bd","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
