{"cross_mech":[],"family":{"alphafold_models":10000,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family is a putative S-adenosyl-L-methionine (SAM)-dependent methyltransferase [[cite:PUB00057461],[cite:PUB00057462]]. In eukaryotes it plays a role in mitochondrial complex I activity [[cite:PUB00057462]].","domain_architectures":112,"interpro_id":"IPR003788","known_evidence_count":null,"matches":13871,"name":"Putative S-adenosyl-L-methionine-dependent methyltransferase","partial_evidence_count":null,"pfam_id":"PF02636","proteins":13694,"proteomes":10337,"short_name":"Methyltransf_28","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02636","structures":6,"taxa":18599,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF02636.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":10000,"domain_architectures":112,"matches":13871,"proteins":13694,"proteomes":10337,"structures":6,"taxa":18599},"curation_status":"SEEDED","description":"This family is a putative S-adenosyl-L-methionine (SAM)-dependent methyltransferase [[cite:PUB00057461],[cite:PUB00057462]]. In eukaryotes it plays a role in mitochondrial complex I activity [[cite:PUB00057462]].","id":"Pfam:PF02636","interpro_id":"InterPro:IPR003788","name":"Putative S-adenosyl-L-methionine-dependent methyltransferase","pfam_id":"PF02636","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Methyltransf_28","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02636"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF02636.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"dd695db11e6b86028ac8d69b880305ce921b4f9461b1235bd3f428f237fc8f75"}},"protein_examples":{"candidate_count":5,"discovery_scanned":true,"example_count":5,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/methyltransf-28-pf02636.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF02636","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/methyltransf-28-pf02636.yaml"}],"pfam_ids":["PF02636"],"protein_name":"Protein arginine methyltransferase NDUFAF7 homolog, mitochondrial","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MMKRLHPLRIQVHLKSDYPLFTFEQLLSTNGIRRGQTARISLKDYIEWQNFPNIMKRENFFTQRKPVTTTAKEEPFSFDNILDCEPQFSKCLAKWLLVNYKLNDYPYYDLNIVNIYTDLPQAIQICKNLMSYLKSTLSDNMFQKIKYFMVPLYKCDKIPSKLLDGIPGSVSLVQDYPVSPYFLQKKFHIEDPIQILMLNDVIKYTTHDLVRYSSDDKGWQQCFVDINKNGQKSKSFDSAIDYSCELALEQMFNDRSHVSPGKELYIPTKLIEILMTIKNNIPEHRLFIVDTPQRSSPTIISLLKSLISPRPTGSSQIVQPYSDSIFSDKRSGRICFMTDFLQLQNIYNGINSSSSSCEVEDVADFVEKWISPSERSTLSSQNGNRPQLEDIKNSSLAVLHST","sequence_length":402,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"230541d2b84862b057d596d2887a428307af0a501e237a2f3f026afa670d3924","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P36052.json","taxon_id":"559292","uniprot_accession":"P36052","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Caenorhabditis elegans","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/methyltransf-28-pf02636.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF02636","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/methyltransf-28-pf02636.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/protein-arginine-methyltransferase-ndufaf7-superfamily-ipr038375.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR038375","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/protein-arginine-methyltransferase-ndufaf7-superfamily-ipr038375.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/3-40-50-12710-3-40-50-12710.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:3.40.50.12710","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/3-40-50-12710-3-40-50-12710.yaml"}],"pfam_ids":["PF02636"],"protein_name":"Protein arginine methyltransferase NDUFAF7 homolog, mitochondrial","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSLRVQNILINSLRQYSKQILKPPGYASPEKTNHLKKFLVDKIRVSGPITVAEYMKTCVSAPLVGYYGQFSKDQKVFGAKGDFITSPELTQLFGEMIGVWVFHELANTGHKGSWQLVELGPGRAQLMNDVLNALAKFNDKDVSVHLVETSDALIDEQEKSLCIYTSKNSIDTPFIRKNKTRTGVNIYWYKSIDDIPDGFTVFIGNEFLDALPIHQFHKSGDSWNEVYVNLTKDGDLCFMKSKGENLHTKGLIPSAIRDDSSRVTWECSPESGTVVNQIVDRITTFGGFSLLVDYGHDGSRNTHSFRAYKNHKQVDTLENPGLADLTADVDFGYLSTLVKDRVVIYGPNEQREFLAQLGIEHRLRRLLQVCKDRKQQEQLIESYNMLMGDMGLKFKAWALFPKTLEFILEQRGGPAGFSAKKKTTEN","sequence_length":426,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"bdd77bd1316d8e04fdf0ec430ce5013d908aa9f38ea235fbb7e1a66ff95b3570","sequence_version":4,"source_url":"https://rest.uniprot.org/uniprotkb/Q09644.json","taxon_id":"6239","uniprot_accession":"Q09644","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/protein-arginine-omega-n-symmetric-methyltransferase-activity-go0035243.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0035243","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/protein-arginine-omega-n-symmetric-methyltransferase-activity-go0035243.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/peptidyl-arginine-methylation-to-symmetrical-dimethyl-arginine-go0019918.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0019918","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/peptidyl-arginine-methylation-to-symmetrical-dimethyl-arginine-go0019918.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/methyltransf-28-pf02636.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF02636","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/methyltransf-28-pf02636.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/protein-arginine-methyltransferase-ndufaf7-superfamily-ipr038375.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR038375","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/protein-arginine-methyltransferase-ndufaf7-superfamily-ipr038375.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/3-40-50-12710-3-40-50-12710.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:3.40.50.12710","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/3-40-50-12710-3-40-50-12710.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q7L592","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF02636"],"protein_name":"Protein arginine methyltransferase NDUFAF7, mitochondrial","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"44c967dad58260d3144a522107b089a2b1cd894b88c00419bbb69415b4b6e7bf","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MSVLLRSGLGPLCAVARAAIPFIWRGKYFSSGNEPAENPVTPMLRHLMYKIKSTGPITVAEYMKEVLTNPAKGYYVYRDMLGEKGDFITSPEISQIFGELLGIWFISEWMATGKSTAFQLVELGPGRGTLVGDILRVFTQLGSVLKNCDISVHLVEVSQKLSEIQALTLTKEKVPLERNAGSPVYMKGVTKSGIPISWYRDLHDVPKGYSFYLAHEFFDVLPVHKFQKTPQGWREVFVDIDPQVSDKLRFVLAPSATPAEAFIQHDETRDHVEVCPDAGVIIEELSQRIALTGGAALVADYGHDGTKTDTFRGFCDHKLHDVLIAPGTADLTADVDFSYLRRMAQGKVASLGPIKQHTFLKNMGIDVRLKVLLDKSNEPSVRQQLLQGYDMLMNPKKMGERFNFFALLPHQRLQGGRYQRNARQSKPFASVVAGFSELAWQ","sequence_length":441,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"44c967dad58260d3144a522107b089a2b1cd894b88c00419bbb69415b4b6e7bf","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q7L592.json","taxon_id":"9606","uniprot_accession":"Q7L592","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/peptidyl-arginine-methylation-to-symmetrical-dimethyl-arginine-go0019918.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0019918","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/peptidyl-arginine-methylation-to-symmetrical-dimethyl-arginine-go0019918.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/methyltransf-28-pf02636.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF02636","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/methyltransf-28-pf02636.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/protein-arginine-methyltransferase-ndufaf7-superfamily-ipr038375.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR038375","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/protein-arginine-methyltransferase-ndufaf7-superfamily-ipr038375.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/3-40-50-12710-3-40-50-12710.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:3.40.50.12710","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/3-40-50-12710-3-40-50-12710.yaml"}],"pfam_ids":["PF02636"],"protein_name":"Protein arginine methyltransferase NDUFAF7, mitochondrial","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MNALVRRCVARAGLPCIWRGKCYSSGNEPAESNQVTPMLRHLMYKIKSTGPITVAEYMKEVLTNPAKGYYVHQDMLGEKGDFITSPEISQIFGELLGVWFVSEWIASGKSPAFQLVELGPGRGTLTADILRVFSQLGSVLKTCAISIHLVEVSQKLSEIQALTLAEEKVPLERDAESLVYMKGVTKSGIPVSWYRDLKDVPEGYSLYLAHEFFDVLPVHKFQKTPRGWREVFVDVDPQASDKLRFVLAPCATPAEAFIQRDERREHVEVCPDAGVIIQELSQRIASTGGAALIADYGHDGTKTDTLRGFYGHQLHDVLIAPGTADLTADVDFSYLRRMAQGKVASLGPVEQRTFLKNMGIDVRLKVLLDKAGEPSAKQQLLGGYDMLMNPQKMGERFHFFALLPHQRLHGGSQERNACQSKTPSSSVAGFDELVWQ","sequence_length":436,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"17891f1aafe8c63160e109933fb99d2ec21c5aa08871ac3476eaadeaf4cef52f","sequence_version":4,"source_url":"https://rest.uniprot.org/uniprotkb/Q9CWG8.json","taxon_id":"10090","uniprot_accession":"Q9CWG8","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Drosophila melanogaster","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/methyltransf-28-pf02636.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF02636","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/methyltransf-28-pf02636.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/protein-arginine-methyltransferase-ndufaf7-superfamily-ipr038375.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR038375","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/protein-arginine-methyltransferase-ndufaf7-superfamily-ipr038375.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/3-40-50-12710-3-40-50-12710.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:3.40.50.12710","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/3-40-50-12710-3-40-50-12710.yaml"}],"pfam_ids":["PF02636"],"protein_name":"Protein arginine methyltransferase NDUFAF7 homolog, mitochondrial","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MLREALRIGNRRWYSYKSVRRPNLGATGTPKMEPPKEQPEASSKAESGHGSLAKQLRAKILSTGPIPVAEYMREVLTNPQAGYYMNRDVFGREGDFITSPEISQIFGELVGIWLVSEWRKMGSPSPFQLVELGPGRGTLARDVLKVLTKFKQDAEFSMHMVEVSPFLSKAQAQRFCYSHQTLPEDAQLPHYQEGTTASGTKAFWHRRLEDVPQGFSLVLAHEFFDALPVHKLQLVDGKWQEVLIDVASSDGAQEASFRYVLSRSQTPVSSLYRPLPGETRSCLEHSLETERQVGLLAERIERDGGIALIMDYGHFGEKTDTFRAFKQHKLHDPLVEPGSADLTADVDFKLVRHIAETRGNVHCCGPVEQGLFLQRMQGEARLEQLLAHALPENQEIIRSGYEMLTDPAQMGTRFKFLAMFPGVLAAHLDKYPVVGFS","sequence_length":437,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"b9c258a953de29cd90f4eaf969fa6eb7353e7fe315a2f30948a4cde9de0e734f","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9VGR2.json","taxon_id":"7227","uniprot_accession":"Q9VGR2","uniprot_release":"2026_03"}],"pfam_id":"PF02636","short_name":"Methyltransf_28","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
