{"cross_mech":[],"family":{"alphafold_models":1094,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This domain is found in members of the Dicer protein family which function in RNA interference, an evolutionarily conserved mechanism for gene silencing using double-stranded RNA (dsRNA) molecules. It is essential for the activity of Dicer [[cite:PUB00067933],[cite:PUB00043694]]. It is a divergent double stranded RNA-binding domain [[cite:PUB00043692]]. The N-terminal alpha helix of this domain is in a different orientation to that found in canonical dsRNA-binding domains. This results in a change of charge distribution at the potential dsRNA-binding surface and in the N- and C-termini of the domain being in close proximity [[cite:PUB00066744]]. This domain has weak dsRNA-binding activity. It mediates heterodimerisation of Dicer proteins with their respective protein partners [[cite:PUB00066744]].","domain_architectures":386,"interpro_id":"IPR005034","known_evidence_count":null,"matches":8274,"name":"Dicer dimerisation domain","partial_evidence_count":null,"pfam_id":"PF03368","proteins":8259,"proteomes":2973,"short_name":"Dicer_dimer","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03368","structures":47,"taxa":8119,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF03368.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1094,"domain_architectures":386,"matches":8274,"proteins":8259,"proteomes":2973,"structures":47,"taxa":8119},"curation_status":"SEEDED","description":"This domain is found in members of the Dicer protein family which function in RNA interference, an evolutionarily conserved mechanism for gene silencing using double-stranded RNA (dsRNA) molecules. It is essential for the activity of Dicer [[cite:PUB00067933],[cite:PUB00043694]]. It is a divergent double stranded RNA-binding domain [[cite:PUB00043692]]. The N-terminal alpha helix of this domain is in a different orientation to that found in canonical dsRNA-binding domains. This results in a change of charge distribution at the potential dsRNA-binding surface and in the N- and C-termini of the domain being in close proximity [[cite:PUB00066744]]. This domain has weak dsRNA-binding activity. It mediates heterodimerisation of Dicer proteins with their respective protein partners [[cite:PUB00066744]].","id":"Pfam:PF03368","interpro_id":"InterPro:IPR005034","name":"Dicer dimerisation 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