{"cross_mech":[],"family":{"alphafold_models":38963,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"These probable extra-cytoplasmic solute receptors are strongly overrepresented in several beta-proteobacteria [[cite:PUB00019234]]. This family, formerly known as Bug - Bordetella uptake gene (bug) product - is a family of bacterial tripartite tricarboxylate receptors of the extracytoplasmic solute binding receptor-dependent transporter group of families, distinct from the ABC and TRAP-T families [[cite:PUB00106922]]. The TctABC system has been characterised in S. typhimurium [[cite:PUB00106923]], and TctC is the extracytoplasmic tricarboxylate-binding receptor which binds the transporters TctA and TctB, two integral membrane proteins. Complete three-component systems are found only in bacteria [[cite:PUB00106923]].","domain_architectures":60,"interpro_id":"IPR005064","known_evidence_count":null,"matches":64621,"name":"Tripartite tricarboxylate transporter family receptor","partial_evidence_count":null,"pfam_id":"PF03401","proteins":64590,"proteomes":6826,"short_name":"TctC","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03401","structures":13,"taxa":9512,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF03401.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":38963,"domain_architectures":60,"matches":64621,"proteins":64590,"proteomes":6826,"structures":13,"taxa":9512},"curation_status":"SEEDED","description":"These probable extra-cytoplasmic solute receptors are strongly overrepresented in several beta-proteobacteria [[cite:PUB00019234]]. This family, formerly known as Bug - Bordetella uptake gene (bug) product - is a family of bacterial tripartite tricarboxylate receptors of the extracytoplasmic solute binding receptor-dependent transporter group of families, distinct from the ABC and TRAP-T families [[cite:PUB00106922]]. The TctABC system has been characterised in S. typhimurium [[cite:PUB00106923]], and TctC is the extracytoplasmic tricarboxylate-binding receptor which binds the transporters TctA and TctB, two integral membrane proteins. Complete three-component systems are found only in bacteria [[cite:PUB00106923]].","id":"Pfam:PF03401","interpro_id":"InterPro:IPR005064","name":"Tripartite tricarboxylate transporter family receptor","pfam_id":"PF03401","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"TctC","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03401"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF03401.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"ad92ade6e9b3687f47ceaa974aa440944d4e294429aa1166ee296d6df781b190"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Bacillus subtilis (strain 168)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/bug-bordetella-uptake-gene-protein-family-of-periplasmic-solute-bindin-cd07012.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd07012","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/bug-bordetella-uptake-gene-protein-family-of-periplasmic-solute-bindin-cd07012.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/tctc-pf03401.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF03401","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/tctc-pf03401.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/bordetella-uptake-gene-domain-1-ipr042100.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR042100","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/bordetella-uptake-gene-domain-1-ipr042100.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/bordetella-uptake-gene-domain-1-3-40-190-150.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:3.40.190.150","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/bordetella-uptake-gene-domain-1-3-40-190-150.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:O34439","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF03401"],"protein_name":"UPF0065 protein YflP","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"49d728e244fa3ffac07e2a06bf85f869010c40e3fcd453005c482745d46c4f0c","sequence_version":2,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MKKSIILLNILLIFMQGDIRQAAAPRLPDGPIEIVVPAEPSGGWDVTAQAIQSVLRQKQIVKDDVHIVYKSGGGGEKGWKYVNKSSKQTISMTSSLILSNDLLGQSKLKMSDFTPLAILSKEWQTVALPKGSALTNGKDVLNEINMHPGKVRIGFAPGFGNDDQLSFVRAADMYGIDPFDIQFSQYDSSEQLIQALIRHEIEAASMTLSEAKPYERNGDITLAAVTSDKRLPGFPNVPTWKEQGIPFVFSHWRGILGPKNMSEEEISYWDQALKKVTSSPEWKRKINEQDWESFYLNSRETKRFLEEQSAFYQSIMTGN","sequence_length":319,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"49d728e244fa3ffac07e2a06bf85f869010c40e3fcd453005c482745d46c4f0c","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/O34439.json","taxon_id":"224308","uniprot_accession":"O34439","uniprot_release":"2026_03"}],"pfam_id":"PF03401","short_name":"TctC","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
