{"cross_mech":[],"family":{"alphafold_models":3231,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family of proteins the superfamily of PHD-finger proteins. At least one example, from mouse, may act as a chromatin-associated protein[[cite:PUB00020105]]. The S. pombe ini1 gene is essential, required for splicing [[cite:PUB00020106]]. It is localised in the nucleus, but not detected in the nucleolus and can be complemented by human ini1 [[cite:PUB00020106]].","domain_architectures":72,"interpro_id":"IPR005345","known_evidence_count":null,"matches":3792,"name":"PHF5-like protein","partial_evidence_count":null,"pfam_id":"PF03660","proteins":3763,"proteomes":3034,"short_name":"PHF5","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03660","structures":75,"taxa":8299,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF03660.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":3231,"domain_architectures":72,"matches":3792,"proteins":3763,"proteomes":3034,"structures":75,"taxa":8299},"curation_status":"SEEDED","description":"This family of proteins the superfamily of PHD-finger proteins. At least one example, from mouse, may act as a chromatin-associated protein[[cite:PUB00020105]]. The S. pombe ini1 gene is essential, required for splicing [[cite:PUB00020106]]. It is localised in the nucleus, but not detected in the nucleolus and can be complemented by human ini1 [[cite:PUB00020106]].","id":"Pfam:PF03660","interpro_id":"InterPro:IPR005345","name":"PHF5-like protein","pfam_id":"PF03660","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"PHF5","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03660"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF03660.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"a5516cd6faa830ff79d64d4c8b011b7b5d4cec9b3f0f803446984dba8de11628"}},"protein_examples":{"candidate_count":6,"discovery_scanned":true,"example_count":6,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Arabidopsis thaliana","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/phf5-pf03660.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF03660","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/phf5-pf03660.yaml"}],"pfam_ids":["PF03660"],"protein_name":"PHD finger-like domain-containing protein 5A","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAKHHPDLIMCRKQPGIAIGRLCEKCDGKCVICDSYVRPCTLVRICDECNYGSFQGRCVICGGVGISDAYYCKECTQQEKDRDGCPKIVNLGSAKTDLFYERKKYGFKKR","sequence_length":110,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"971cfa66ff36b76222957225bafe17e27cd11d2c001a0469eeab3890161f09cf","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P0DI19.json","taxon_id":"3702","uniprot_accession":"P0DI19","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/u12-type-catalytic-step-2-spliceosome-go0071018.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0071018","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/u12-type-catalytic-step-2-spliceosome-go0071018.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/u12-type-precatalytic-spliceosome-go0071016.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0071016","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/u12-type-precatalytic-spliceosome-go0071016.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/phf5-pf03660.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF03660","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/phf5-pf03660.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:P83870","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF03660"],"protein_name":"PHD finger-like domain-containing protein 5A","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"3d95a8b5ec80668b45320dce3e008c57dfbb760f92912ac00e49f5c55f22c7be","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MAKHHPDLIFCRKQAGVAIGRLCEKCDGKCVICDSYVRPCTLVRICDECNYGSYQGRCVICGGPGVSDAYYCKECTIQEKDRDGCPKIVNLGSSKTDLFYERKKYGFKKR","sequence_length":110,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"3d95a8b5ec80668b45320dce3e008c57dfbb760f92912ac00e49f5c55f22c7be","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P83870.json","taxon_id":"10090","uniprot_accession":"P83870","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/phf5-pf03660.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF03660","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/phf5-pf03660.yaml"}],"pfam_ids":["PF03660"],"protein_name":"Pre-mRNA-splicing factor RDS3","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSRHQFDLIMCLKQPGVQTGLLCEKCDGKCPICDSYVRPKRKVRVCENCSFGKQAKNCIICNLNVGVNDAFYCWECCRLGKDKDGCPRILNLGSNRLDRHFEKKKKV","sequence_length":107,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"e3c29be9c8fdcd10569a5caa973a61c686fef51a048abf2a608de4a5ccad3912","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q06835.json","taxon_id":"559292","uniprot_accession":"Q06835","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Arabidopsis thaliana","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/phf5-pf03660.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF03660","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/phf5-pf03660.yaml"}],"pfam_ids":["PF03660"],"protein_name":"PHD finger-like domain-containing protein 5B","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAKHHPDLIMCRKQPGIAIGRLCEKCDGKCVICDSYVRPCTLVRICDECNYGSFQGRCVICGGVGISDAYYCKECTQQEKDRDGCPKIVNLGSAKTDLFYERKKYGFKKR","sequence_length":110,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"971cfa66ff36b76222957225bafe17e27cd11d2c001a0469eeab3890161f09cf","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q0WMV8.json","taxon_id":"3702","uniprot_accession":"Q0WMV8","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/phf5-pf03660.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF03660","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/phf5-pf03660.yaml"}],"pfam_ids":["PF03660"],"protein_name":"PHD finger-like domain-containing protein 5A","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAKHHPDLIFCRKQAGVAIGRLCEKCDGKCVICDSYVRPCTLVRICDECNYGSYQGRCVICGGPGVSDAYYCKECTIQEKDRDGCPKIVNLGSSKTDLFYERKKYGFKKR","sequence_length":110,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"3d95a8b5ec80668b45320dce3e008c57dfbb760f92912ac00e49f5c55f22c7be","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q7RTV0.json","taxon_id":"9606","uniprot_accession":"Q7RTV0","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Drosophila melanogaster","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/phf5-pf03660.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF03660","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/phf5-pf03660.yaml"}],"pfam_ids":["PF03660"],"protein_name":"PHD finger-like domain-containing protein 5A","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAKHHPDLIFCRKQPGVAIGRLCEKDDGKCVICDSYVRPCTLVRICDECNYGSYQGRCVICGGPGVSDAYYCKSCTIQEKDRDGCPKIVNLGSSKTDLFYERKKYGFKQNY","sequence_length":111,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"1bd64572e27cc8d0caf05cb4cb9de2f85f6a7f2e71711d0454acd7e223c1033d","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q9VMC8.json","taxon_id":"7227","uniprot_accession":"Q9VMC8","uniprot_release":"2026_03"}],"pfam_id":"PF03660","short_name":"PHF5","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}