{"cross_mech":[],"family":{"alphafold_models":2990,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This is a family of integral membrane proteins, which may contain four transmembrane helices. Members of this family are thought to be involved in sterol C-4 demethylation. In S. cerevisiae they may tether Erg26p (sterol dehydrogenase/decarboxylase) and Erg27p (3-ketoreductase) to the endoplasmic reticulum or may facilitate interaction between these proteins [[cite:PUB00019518]]. The family contains a conserved arginine and histidine that may be functionally important.","domain_architectures":47,"interpro_id":"IPR005352","known_evidence_count":null,"matches":3525,"name":"Erg28 like protein","partial_evidence_count":null,"pfam_id":"PF03694","proteins":3505,"proteomes":2752,"short_name":"Erg28","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03694","structures":0,"taxa":7329,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF03694.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":2990,"domain_architectures":47,"matches":3525,"proteins":3505,"proteomes":2752,"structures":0,"taxa":7329},"curation_status":"SEEDED","description":"This is a family of integral membrane proteins, which may contain four transmembrane helices. Members of this family are thought to be involved in sterol C-4 demethylation. In S. cerevisiae they may tether Erg26p (sterol dehydrogenase/decarboxylase) and Erg27p (3-ketoreductase) to the endoplasmic reticulum or may facilitate interaction between these proteins [[cite:PUB00019518]]. The family contains a conserved arginine and histidine that may be functionally important.","id":"Pfam:PF03694","interpro_id":"InterPro:IPR005352","name":"Erg28 like protein","pfam_id":"PF03694","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Erg28","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03694"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF03694.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"8ea3a9c6462de7a1ac81817fe4ae2d798191cb1bb42da2fe3e4d6730b7296d12"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Schizosaccharomyces pombe (strain 972 / ATCC 24843)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/erg28-pf03694.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF03694","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/erg28-pf03694.yaml"}],"pfam_ids":["PF03694"],"protein_name":"Ergosterol biosynthetic protein 28","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSQILAMLPDSLVAKWNVVVSVAALFNTVQSFLTPKLTKRVYSNTNEVNGLQGRTFGIWTLLSAIVRFYCAYHITNPDVYFLCQCTYYLACFHFLSEWLLFRTTNLGPGLLSPIVVSTVSIWFMAKEKASILGIAA","sequence_length":136,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"32604a206dbd0c18d803989cb9e0b9a7881cf5c593d689c9479c4b588ba337c4","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/O74820.json","taxon_id":"284812","uniprot_accession":"O74820","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/erg28-pf03694.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF03694","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/erg28-pf03694.yaml"}],"pfam_ids":["PF03694"],"protein_name":"Ergosterol biosynthetic protein 28","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MFSLQDVITTTKTTLAAMPKGYLPKWLLFISIVSVFNSIQTYVSGLELTRKVYERKPTETTHLSARTFGTWTFISCVIRFYGAMYLNEPHIFELVFMSYMVALFHFGSELLIFRTCKLGKGFMGPLVVSTTSLVWMYKQREYYTGVAW","sequence_length":148,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"1bde25b4af0a369f76b574c9bbfdfea583267dd56cfbf24646905f2f9b56c2a6","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P40030.json","taxon_id":"559292","uniprot_accession":"P40030","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/erg28-pf03694.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF03694","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/erg28-pf03694.yaml"}],"pfam_ids":["PF03694"],"protein_name":"Ergosterol biosynthetic protein 28 homolog","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSRFLNVLRSWLVMVSIIAMGNTLQSFRDHTFLYEKLYTGKPNLVNGLQARTFGIWTLLSSVIRCLCAIDIHNKTLYHITLWTFLLALGHFLSELFVYGTAAPTIGVLAPLMVASFSILGMLVGLRYLEVEPVSRQKKRN","sequence_length":140,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"ced9262ea7b495b998308dc1a2669fdedeb512a22fb11a2f640ca8b9ed7b41f8","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9UKR5.json","taxon_id":"9606","uniprot_accession":"Q9UKR5","uniprot_release":"2026_03"}],"pfam_id":"PF03694","short_name":"Erg28","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}