{"cross_mech":[],"family":{"alphafold_models":10109,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This is a family of serine hydrolases [[cite:PUB00021049]].","domain_architectures":361,"interpro_id":"IPR005645","known_evidence_count":null,"matches":12619,"name":"Serine hydrolase (FSH1)","partial_evidence_count":null,"pfam_id":"PF03959","proteins":12327,"proteomes":3521,"short_name":"FSH1","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03959","structures":1,"taxa":9325,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF03959.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":10109,"domain_architectures":361,"matches":12619,"proteins":12327,"proteomes":3521,"structures":1,"taxa":9325},"curation_status":"SEEDED","description":"This is a family of serine hydrolases [[cite:PUB00021049]].","id":"Pfam:PF03959","interpro_id":"InterPro:IPR005645","name":"Serine hydrolase (FSH1)","pfam_id":"PF03959","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"FSH1","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03959"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF03959.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"aa7eb2c8d43c633a8fde159637b23090185cb509f6f768c78e17a5c1f0ee54dc"}},"protein_examples":{"candidate_count":9,"discovery_scanned":true,"example_count":9,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/serine-hydrolase-domain-ipr005645.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR005645","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/serine-hydrolase-domain-ipr005645.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/fsh1-pf03959.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF03959","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/fsh1-pf03959.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:P38777","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF03959"],"protein_name":"Family of serine hydrolases 1","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"00447844e7fba76d04bcb3bfab3086ee24184957ad01e98937dd331bda507ae5","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MTVQIPKLLFLHGFLQNGKVFSEKSSGIRKLLKKANVQCDYIDAPVLLEKKDLPFEMDDEKWQATLDADVNRAWFYHSEISHELDISEGLKSVVDHIKANGPYDGIVGFSQGAALSSIITNKISELVPDHPQFKVSVVISGYSFTEPDPEHPGELRITEKFRDSFAVKPDMKTKMIFIYGASDQAVPSVRSKYLYDIYLKAQNGNKEKVLAYEHPGGHMVPNKKDIIRPIVEQITSSLQEASE","sequence_length":243,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"00447844e7fba76d04bcb3bfab3086ee24184957ad01e98937dd331bda507ae5","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P38777.json","taxon_id":"559292","uniprot_accession":"P38777","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/serine-hydrolase-domain-ipr005645.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR005645","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/serine-hydrolase-domain-ipr005645.yaml"}],"pfam_ids":["PF03959"],"protein_name":"Family of serine hydrolases 2","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTKNVLMLHGLAQSGDYFASKTKGFRAEMEKLGYKLYYPTAPNEFPPADVPDFLGEVIADAPGDGENTGVLAWLENDPSTGGYFIPQTTIDYLHNYVLENGPFAGIVGFSQGAGVAGYLATDFNGLLGLTTEEQPPLEFFMAVSGFRFQPQQYQEQYDLHPISVPSLHVQGELDTITEPAKVQGLYNSCTEDSRTLLMHSGGHFVPNSRGFVRKVAQWLQQLT","sequence_length":223,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"4201de354c649815822df89d2fab53efa33876424cc948e90e8644a586d8e159","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q05015.json","taxon_id":"559292","uniprot_accession":"Q05015","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Caenorhabditis elegans","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/serine-hydrolase-domain-ipr005645.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR005645","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/serine-hydrolase-domain-ipr005645.yaml"}],"pfam_ids":["PF03959"],"protein_name":"Esterase C25G4.2","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSSQPKLRILCLHGYRQCDQSFRQKTGSTRKLVKSLAEFEFVNGVHSVAVDEHVDSSRAWWFSNNEAMSFSSRESTEVAVGFEESVAAVVKFIEENGPFDGLLGFSQGASMVHLLIAKAQLGEIKLPGIRFAIFFSGFLSLSSKHDSLTLLRIKEFPSMHVFGDADEIVARPKSEKMADMFDVEPLRIAHDGGHVVPSMSKHKEKIAGFMREQLDRKIENN","sequence_length":221,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"c1313fdb06fcd61f2b2540105b4c1a701cc1f6c1a447d3568fd7fdc38da2f905","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q18169.json","taxon_id":"6239","uniprot_accession":"Q18169","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)","origins":[{"cited_uniprot_accession":"Q5B7I6","commit":"e66f934111777c4ebfe69475d0520c0cfa074785","link_basis":["uniprot_pfam_xref"],"mech":"NaturalProductMech","path":"data/natural_products/amino_acids_and_peptides/fellutamide-b.yaml","qualification_status":"NOT_ASSESSED","record_id":"naturalproductmech:mibig-a7c02b2a6d","section":"uniprot_accession","url":"https://github.com/CultureBotAI/NaturalProductMech/blob/e66f934111777c4ebfe69475d0520c0cfa074785/data/natural_products/amino_acids_and_peptides/fellutamide-b.yaml"}],"pfam_ids":["PF03959"],"protein_name":"Esterase inpF","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MRILFFHGHTQTGPVFERKTVRLREHIQRAYPGSTFFFPTGPIAYKVSDRLDYLSEIQRERSDNFKDPDLIETHAWFRLFEDDPPRGLLESLDIAAEILRVEGPFDGVICFSQGSVVGSMMASLLEGPRRRQRFDEYAASFPGAVRYPKSYKNINHPPLKFGITYGAYMGTSPVFNAFYSEPLIETPFLHFMGEFDPVVPSEMVAAVDKAQIGGSRRRKVMHPGAHAIPVGDRYHEAVVDFIRSACETSPTYFDLPSDEVPLLSYNDTPEQTPFQTPLLTPSLSSAVSTTSIPSSEATILATRRLDQWEKSRSPRSNIRPRSTRRTVFSGRRSTSSSAESSAASQHSDHFEATRTPTSSTSTVQMIEPTVNKEPNLAVRVVEDDTIVSGSEYEGEGWQELLLSDLLNEMLRRHGRPGRFYFVPDGEGGRLENGMRLN","sequence_length":437,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"49326b1037ad2fcce9a2767ec475f88bb15bf27898f2f2f73602ae05737309b4","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q5B7I6.json","taxon_id":"227321","uniprot_accession":"Q5B7I6","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)","origins":[{"cited_uniprot_accession":"Q5BEJ8","commit":"e66f934111777c4ebfe69475d0520c0cfa074785","link_basis":["uniprot_pfam_xref"],"mech":"NaturalProductMech","path":"data/natural_products/polyketides/asperfuranone.yaml","qualification_status":"NOT_ASSESSED","record_id":"naturalproductmech:mibig-3358de9614","section":"uniprot_accession","url":"https://github.com/CultureBotAI/NaturalProductMech/blob/e66f934111777c4ebfe69475d0520c0cfa074785/data/natural_products/polyketides/asperfuranone.yaml"}],"pfam_ids":["PF03959"],"protein_name":"Probable esterase afoC","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MPALDIASAPAAVYQQQLHLPRILCLHGGGTNARIFTAQCRALRRQLTDSYRLVFADAPFLSSAGPDVTSVYGEWGPFRSWVPVPAGVDISAWAAAGAASRIDIDVEAIDECIAAAIAQDDRAGATGDWVGLLGFSQGARVAASLLYRQQKQQRMGLTSWSRGRDRKRGATSSTNYRFAVLFAGRGPLLDLGFGSGSLAGSSAASSSASASVSGSESAGEEEEDGHLLSIPTIHVHGLRDPGLEMHRDLVRSCRPSSVRIVEWEGAHRMPITTKDVGAVVAELRHLAISRKYESLRC","sequence_length":297,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"a22e53ad041a11dd18a898d72203faa6a06bf3205e57fbae9a0e0a294b730692","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q5BEJ8.json","taxon_id":"227321","uniprot_accession":"Q5BEJ8","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/serine-hydrolase-domain-ipr005645.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR005645","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/serine-hydrolase-domain-ipr005645.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/fsh1-pf03959.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF03959","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/fsh1-pf03959.yaml"}],"pfam_ids":["PF03959"],"protein_name":"Esterase OVCA2","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAAQRPLRVLCLAGFRQSERGFREKTGALRKALRGRAELVCLSGPHPVPDPPGPEGARSDFGSCPPEEQPRGWWFSEQEADVFSALEEPAVCRGLEESLGMVAQALNRLGPFDGLLGFSQGAALAALVCALGQAGDPRFPLPRFILLVSGFCPRGIGFKESILQRPLSLPSLHVFGDTDKVIPSQESVQLASQFPGAITLTHSGGHFIPAAAPQRQAYLKFLDQFAE","sequence_length":227,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"8a75002e32a6930020a74c31f44d7335ae2cdab8e7b58f90424a6063830d6262","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8WZ82.json","taxon_id":"9606","uniprot_accession":"Q8WZ82","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/serine-hydrolase-domain-ipr005645.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR005645","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/serine-hydrolase-domain-ipr005645.yaml"}],"pfam_ids":["PF03959"],"protein_name":"Family of serine hydrolases 3","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSEKKKVLMLHGFVQSDKIFSAKTGGLRKNLKKLGYDLYYPCAPHSIDKKALFQSESEKGRDAAKEFNTSATSDEVYGWFFRNPESFNSFQIDQKVFNYLRNYVLENGPFDGVIGFSQGAGLGGYLVTDFNRILNLTDEQQPALKFFISFSGFKLEDQSYQKEYHRIIQVPSLHVRGELDEVVAESRIMALYESWPDNKRTLLVHPGAHFVPNSKPFVSQVCNWIQGITSKEGQEHNAQPEVDRKQFDKPQLEDDLLDMIDSLGKL","sequence_length":266,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"152278b84e7ed5ccc69ed768b7d5502b2164906d2d36b80d0d6df6b34acf0369","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q99369.json","taxon_id":"559292","uniprot_accession":"Q99369","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/serine-hydrolase-domain-ipr005645.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR005645","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/serine-hydrolase-domain-ipr005645.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/fsh1-pf03959.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF03959","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/fsh1-pf03959.yaml"}],"pfam_ids":["PF03959"],"protein_name":"Esterase OVCA2","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAARQTLRVLCLAGFRQSERGFREKTGALRKTLRGRAELVCLSGPHPVPEAAAPEGSCPDSGPCSPEEQPRGWWFSEEEADVFSALEESTVCRGLQEALETVARALDTLGPFDGLLGFSQGAALAAYVCALGQAGDPRFPLPRFIILVSGFCPRGLKEPILQSPMSLPSLHVFGDTDRVIPSQESMQLASRFLGAVTLTHSGGHFIPAAASQRQAYLKFLDQFAE","sequence_length":225,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"051c51fe88e69efbe499c979d6d27458fabcf35e034a9b5d1fff97aa200acec9","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9D7E3.json","taxon_id":"10090","uniprot_accession":"Q9D7E3","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Drosophila melanogaster","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/serine-hydrolase-domain-ipr005645.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR005645","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/serine-hydrolase-domain-ipr005645.yaml"}],"pfam_ids":["PF03959"],"protein_name":"Esterase CG5412","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTNNDAAVEAAGSSRASSSKQQLKLEITEKVRVLCLHGYRQNGEAFKNKLGSFRKFANKYAEFVFITAPHVAKALESAAEPVPEQRSWWANKDDGSFKGTNKGGPAFGFQESLRCVEEAWRTQGPFQGLLGFSQGACFVGLICGLAKKKLTSIRPEFAVLASGFLSGSLVHMSAYEEAISIPTLHIYGQTDEIIPKEMSESLAARFKNAEVLEHSGGHYFPATAQQKQTFINFFQDRLQEYLEHEELQQSGNASFVDSGAEDDNDAEVAAMTAELDESD","sequence_length":279,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"107909a8f3d6fedebb28db30b67c6db762aa8fcb6cf74855dc42eeea785040ae","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9VDL1.json","taxon_id":"7227","uniprot_accession":"Q9VDL1","uniprot_release":"2026_03"}],"pfam_id":"PF03959","short_name":"FSH1","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
