{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF03993","protein_label":"Uncharacterized protein MSMEG_2731/MSMEI_2664","reviewed":true,"short_name":"DUF349","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf349-pf03993.yaml","source_record_id":"Pfam:PF03993","source_record_label":"Domain of Unknown Function (DUF349)","source_section":"canonical_examples","taxon_id":"NCBITaxon:246196","taxon_label":"Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)","uniprot_accession":"A0QVX6","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF03993","protein_label":"Uncharacterized protein MRA_2757","reviewed":true,"short_name":"DUF349","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf349-pf03993.yaml","source_record_id":"Pfam:PF03993","source_record_label":"Domain of Unknown Function (DUF349)","source_section":"canonical_examples","taxon_id":"NCBITaxon:419947","taxon_label":"Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)","uniprot_accession":"A5U683","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF03993","protein_label":"","reviewed":null,"short_name":"DUF349","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf349-pf03993.yaml","source_record_id":"Pfam:PF03993","source_record_label":"Domain of Unknown Function (DUF349)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF03993","protein_label":"","reviewed":null,"short_name":"DUF349","source_category":"sequence/repeat/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/repeat/interpro/protein-of-unknown-function-duf349-ipr007139.yaml","source_record_id":"InterPro:IPR007139","source_record_label":"Protein of unknown function DUF349","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":4199,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":2,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":1},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This domain is found singly or as up to five tandem repeats in a small set of bacterial proteins. There are two or three alpha-helices, and possibly a beta-strand.","domain_architectures":11,"interpro_id":"IPR007139","known_evidence_count":null,"matches":23114,"name":"Domain of Unknown Function (DUF349)","partial_evidence_count":null,"pfam_id":"PF03993","proteins":6957,"proteomes":6539,"short_name":"DUF349","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03993","structures":0,"taxa":8240,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF03993.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":4199,"domain_architectures":11,"matches":23114,"proteins":6957,"proteomes":6539,"structures":0,"taxa":8240},"curation_status":"SEEDED","description":"This domain is found singly or as up to five tandem repeats in a small set of bacterial proteins. There are two or three alpha-helices, and possibly a beta-strand.","id":"Pfam:PF03993","interpro_id":"InterPro:IPR007139","name":"Domain of Unknown Function (DUF349)","pfam_id":"PF03993","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF349","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03993"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF03993.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"17450410dcf98e07510cbc0c49e446a6d315311b3a4d4c6557d393ea926cc7a9"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf349-pf03993.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF03993","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf349-pf03993.yaml"}],"pfam_ids":["PF03993"],"protein_name":"Uncharacterized protein MSMEG_2731/MSMEI_2664","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MRGPPRGVRGADMTTSEPGGATPKPTPRPTPHPTPRPVPRPSRVAPVVAAAPSSDPHRFGRVDPDGTVWLITGSGERVIGAWQAGDTESAFAHFGRRYDDLHTEVALLERRLATGTGDARKIKSAAAALAESLPTASVLGDVDALSARLSSILEQADEAAQNERAQRDEYRAAQTARKEALAAEAEDIAANSTQWKAAGDRLREILDEWRTITGLERKADDALWKRYSAARETFNRRRGSHFAELDRSRVSARQAKEELCERAEALADSTDWGATSAAFRDLLAEWKAAGRAAKDVDDALWQRFKAAQDTFFSARNAAHAERDAEFKANAAAKEALLAEAEKIDLSDNEAARAALRVIGEKWDAIGKVPRERAAELERRLRAIEKKIREAPTGGVDPEAKARADQFRARAEQFERQAEKAEAAGRTKDAEEARASAAQWRQWAEAAAESLEKRR","sequence_length":454,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"3b6a45655688c46056bcb7e072664ace9a563ab61a358f5fd1075edcc6c071d6","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/A0QVX6.json","taxon_id":"246196","uniprot_accession":"A0QVX6","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf349-pf03993.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF03993","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf349-pf03993.yaml"}],"pfam_ids":["PF03993"],"protein_name":"Uncharacterized protein MRA_2757","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTADEPRSDDSSGSAPQPAATPVPRPGPRPGPRPVPRPTSYPVGAHPPSDPHRFGRIDDDGTVWLVSASGERIVGSWQAGDPEAAFAHFGRRFDDLSTEIMLMDERLASGTGDARKIKAHAIALAETLPTACVLGDVDALADRLTSIRDRAEVIAAADRSRREEHRAAQTARKEALAAEAEELAANATQWKVAGDRLRAILDEWKTISGVDRKVDDALWKRYSTARDTFNRRRGSHFAELDRERSGVRQSKERLCERAEELSESTDWTATSAEFRKLLADWKAAGRASKDVDDALWRRFKAAQDSFFTARNAATAEKEAELRANADAKEALLAEAERLDTTNHEAARAALRSIAEKWDAIGKVSRERAAELERRLRAVEKKVREAGEADWSDPQARARAEQFRARAEQFEHQAEKAAAAGRTKEADEAKANAEQWRQWAEAAADALTRRP","sequence_length":450,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"0fb51c7d2bfa65dadbf34a3eed742a6675fe433d09d7bbc3c2db2895bbd79539","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/A5U683.json","taxon_id":"419947","uniprot_accession":"A5U683","uniprot_release":"2026_03"}],"pfam_id":"PF03993","short_name":"DUF349","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}