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It is not known whether other members of this family are peptidase inhibitors.","domain_architectures":91,"interpro_id":"","known_evidence_count":null,"matches":5220,"name":"Peptidase inhibitor family I36","partial_evidence_count":null,"pfam_id":"PF03995","proteins":5144,"proteomes":1963,"short_name":"Inhibitor_I36","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03995","structures":8,"taxa":2813,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF03995.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":2664,"domain_architectures":91,"matches":5220,"proteins":5144,"proteomes":1963,"structures":8,"taxa":2813},"curation_status":"SEEDED","description":"This domain is currently only found in a small set of S. coelicolor secreted proteins. There are four conserved cysteines that probably form two disulphide bonds. Proteins 2SCK31.15C ([swissprot:Q9ADK5]) and SCO3675 ([swissprot:Q9X8V7]) also have probable beta-propellers at their C-termini. This family includes [swissprot:P01077] a known peptidase inhibitor of known structure. This protein has a crystallin like fold [pfam:PF00030] and is distantly related by sequence. It is not known whether other members of this family are peptidase inhibitors.","id":"Pfam:PF03995","name":"Peptidase inhibitor family I36","pfam_id":"PF03995","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Inhibitor_I36","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03995"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF03995.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"2abd8de3e6efd40f3b8e3579cc02f41ef1369f43bc0cfd20ff23438f5f3f5a0e"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Streptomyces nigrescens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/inhibitor-i36-pf03995.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF03995","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/inhibitor-i36-pf03995.yaml"}],"pfam_ids":["PF03995"],"protein_name":"Metalloproteinase inhibitor","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MVRKRALGLAGSALTLVLGAVGFTAPAQAAPSCPAGSLCTYSGTGLSGARTVIPASDMEKAGTDGVKLPASARSFANGTHFTLRYGPARKVTCVRFPCYQYATVGKVAPGAQLRSLPSPGATVTVGQDLGD","sequence_length":131,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"4a8c1213fc1988ee5cfd047af8d3399cf3f1a84e7ca7cf8a9f21c9e021f6dab8","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/P01077.json","taxon_id":"1920","uniprot_accession":"P01077","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Dictyostelium discoideum","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/inhibitor-i36-pf03995.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF03995","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/inhibitor-i36-pf03995.yaml"}],"pfam_ids":["PF03995"],"protein_name":"Uncharacterized gerABC family protein DDB_G0291103","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MNLKSIIFVLFIAFFAFSLANDDDPTCPNGFICFWVGQNYTGDQWKWTPRMNYRDLPRQYHNNVGSYVAKTNACFKNWIPYLTFECNEGDSSHSFTFGKIIDGVSHEC","sequence_length":108,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"575be792f1c4df1ff1dff7a64d5fc1e32e62c517c7b1c3e46dc8fceab3d84e2c","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q54F49.json","taxon_id":"44689","uniprot_accession":"Q54F49","uniprot_release":"2026_03"}],"pfam_id":"PF03995","short_name":"Inhibitor_I36","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}