{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF04016","protein_label":"Uncharacterized protein MJ0500","reviewed":true,"short_name":"DUF364","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4213-ipr025251.yaml","source_record_id":"InterPro:IPR025251","source_record_label":"Domain of unknown function DUF4213","source_section":"canonical_examples","taxon_id":"NCBITaxon:243232","taxon_label":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","uniprot_accession":"Q57923","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF04016","protein_label":"Uncharacterized protein MJ0500","reviewed":true,"short_name":"DUF364","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/putative-heavy-metal-chelation-domain-ipr007161.yaml","source_record_id":"InterPro:IPR007161","source_record_label":"Putative heavy-metal chelation domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:243232","taxon_label":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","uniprot_accession":"Q57923","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF04016","protein_label":"","reviewed":null,"short_name":"DUF364","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/putative-heavy-metal-chelation-domain-ipr007161.yaml","source_record_id":"InterPro:IPR007161","source_record_label":"Putative heavy-metal chelation domain","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF04016","protein_label":"Uncharacterized protein MJ0500","reviewed":true,"short_name":"DUF364","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf364-pf04016.yaml","source_record_id":"Pfam:PF04016","source_record_label":"Putative heavy-metal chelation","source_section":"canonical_examples","taxon_id":"NCBITaxon:243232","taxon_label":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","uniprot_accession":"Q57923","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF04016","protein_label":"","reviewed":null,"short_name":"DUF364","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf364-pf04016.yaml","source_record_id":"Pfam:PF04016","source_record_label":"Putative heavy-metal chelation","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF04016","protein_label":"Uncharacterized protein MJ0500","reviewed":true,"short_name":"DUF364","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4213-pf13938.yaml","source_record_id":"Pfam:PF13938","source_record_label":"Putative heavy-metal chelation","source_section":"canonical_examples","taxon_id":"NCBITaxon:243232","taxon_label":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","uniprot_accession":"Q57923","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF04016","protein_label":"Uncharacterized protein MJ0500","reviewed":true,"short_name":"DUF364","source_category":"structure/homologous_superfamily/cath","source_mech":"ProteinTraitsMech","source_path":"data/traits/structure/homologous_superfamily/cath/3-40-50-11590-3-40-50-11590.yaml","source_record_id":"CATH:3.40.50.11590","source_record_label":"CATH homologous superfamily 3.40.50.11590","source_section":"canonical_examples","taxon_id":"NCBITaxon:243232","taxon_label":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","uniprot_accession":"Q57923","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":1247,"candidate_reasons":["short_name_matches_duf","description_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":1,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":5},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This domain of unknown function has a PLP-dependent transferase-like fold. Its genomic context suggests that it may have a role in anaerobic vitamin B12 biosynthesis. This domain is often found at the C-terminus of proteins containing DUF4213, [pfam:PF13938]. The structure of UnioProtKB:B8FUJ5, PDB:3l5o, suggests that the protein has an enolase N-terminal-like fold and this Rossmann-like C-terminal domain. Structural and bioinformatic analyses reveal partial similarities to Rossmann-like methyltransferases, with residues from the enolase-like fold combining to form a unique active site that is likely to be involved in the condensation or hydrolysis of molecules implicated in the synthesis of flavins, pterins or other siderophores. The protein may be playing a role in heavy-metal chelation [[cite:PUB00075371]].","domain_architectures":6,"interpro_id":"IPR007161","known_evidence_count":null,"matches":1766,"name":"Putative heavy-metal chelation","partial_evidence_count":null,"pfam_id":"PF04016","proteins":1766,"proteomes":1491,"short_name":"DUF364","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04016","structures":2,"taxa":2706,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF04016.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1247,"domain_architectures":6,"matches":1766,"proteins":1766,"proteomes":1491,"structures":2,"taxa":2706},"curation_status":"SEEDED","description":"This domain of unknown function has a PLP-dependent transferase-like fold. Its genomic context suggests that it may have a role in anaerobic vitamin B12 biosynthesis. This domain is often found at the C-terminus of proteins containing DUF4213, [pfam:PF13938]. The structure of UnioProtKB:B8FUJ5, PDB:3l5o, suggests that the protein has an enolase N-terminal-like fold and this Rossmann-like C-terminal domain. Structural and bioinformatic analyses reveal partial similarities to Rossmann-like methyltransferases, with residues from the enolase-like fold combining to form a unique active site that is likely to be involved in the condensation or hydrolysis of molecules implicated in the synthesis of flavins, pterins or other siderophores. The protein may be playing a role in heavy-metal chelation [[cite:PUB00075371]].","id":"Pfam:PF04016","interpro_id":"InterPro:IPR007161","name":"Putative heavy-metal chelation","pfam_id":"PF04016","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF364","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04016"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF04016.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"b1b1ffb1a85107ee0577758a20e4647e4f632977cdd65cdf8fc3f5fd508e9d2d"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4213-ipr025251.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR025251","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4213-ipr025251.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/putative-heavy-metal-chelation-domain-ipr007161.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR007161","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/putative-heavy-metal-chelation-domain-ipr007161.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf364-pf04016.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04016","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf364-pf04016.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf4213-pf13938.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF13938","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf4213-pf13938.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/3-40-50-11590-3-40-50-11590.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:3.40.50.11590","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/3-40-50-11590-3-40-50-11590.yaml"}],"pfam_ids":["PF04016","PF13938"],"protein_name":"Uncharacterized protein MJ0500","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSFMIIEEIKERALNLLSEKEEDFKVIDFSFALPYSYVLIESNGKKALGVAMTLLEEYRGHGNRKDLNINKNLEEFINMADSFDIVERTLGVAAINAVSQYYFNFEANGKDAAELVLNRDDIKKIAFVGNMIPVVNMLKKSEKFDIYVFERSPSLLMDGVLSDAFEYRLLPEMDAVFISGTTLLNDTLDFVLDRAKNAKLKILVGPTAQSLPELFKGFGITHIASTKIIDVDKALLYLKFASSSMLFKGASKKYTMEVE","sequence_length":259,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"50c270e8bebda4dd3f042c931b8a157f9789377eee436a4a62b1e32d76ec064b","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q57923.json","taxon_id":"243232","uniprot_accession":"Q57923","uniprot_release":"2026_03"}],"pfam_id":"PF04016","short_name":"DUF364","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
