{"cross_mech":[],"family":{"alphafold_models":3875,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family contains a ribonuclease P subunit of humans and yeast. Other members of the family include the probable archaeal homologues. This family includes SNM1 [[cite:PUB00017140]]. It is a subunit of RNase MRP (mitochondrial RNA processing), a ribonucleoprotein endoribonuclease that has roles in both mitochondrial DNA replication and nuclear 5.8S rRNA processing. SNM1 is an RNA binding protein that binds the MRP RNA specifically [[cite:PUB00017140]]. This subunit possibly binds the precursor tRNA [[cite:PUB00010581]].","domain_architectures":63,"interpro_id":"IPR007175","known_evidence_count":null,"matches":4495,"name":"RNAse P Rpr2/Rpp21/SNM1 subunit domain","partial_evidence_count":null,"pfam_id":"PF04032","proteins":4495,"proteomes":3138,"short_name":"Rpr2","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04032","structures":13,"taxa":8020,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF04032.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":3875,"domain_architectures":63,"matches":4495,"proteins":4495,"proteomes":3138,"structures":13,"taxa":8020},"curation_status":"SEEDED","description":"This family contains a ribonuclease P subunit of humans and yeast. Other members of the family include the probable archaeal homologues. This family includes SNM1 [[cite:PUB00017140]]. It is a subunit of RNase MRP (mitochondrial RNA processing), a ribonucleoprotein endoribonuclease that has roles in both mitochondrial DNA replication and nuclear 5.8S rRNA processing. SNM1 is an RNA binding protein that binds the MRP RNA specifically [[cite:PUB00017140]]. This subunit possibly binds the precursor tRNA [[cite:PUB00010581]].","id":"Pfam:PF04032","interpro_id":"InterPro:IPR007175","name":"RNAse P Rpr2/Rpp21/SNM1 subunit domain","pfam_id":"PF04032","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Rpr2","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04032"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF04032.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"18dab393eb7cd48f1931882500bd9c438bf4c6ac8b1a631bfca40b9dfe25885a"}},"protein_examples":{"candidate_count":5,"discovery_scanned":true,"example_count":5,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/rpr2-pf04032.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04032","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/rpr2-pf04032.yaml"}],"pfam_ids":["PF04032"],"protein_name":"Ribonuclease P protein subunit RPR2","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MGKKAHGGKMKPEIDENGTLLVPPPRTIANQDHFHRLNYLYQISAYQTRARQKARTDAHTPLARNYIKSMDLISKKTKTSLLPTIKRTICKKCHRLLWTPKKLEITSDGALSVMCGCGTVKRFNIGADPNYRTYSEREGNLLNS","sequence_length":144,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"968329d674b4ecbc879852e0566cd7a172f4b4b132e1429f0007e0d21d9801fe","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P40571.json","taxon_id":"559292","uniprot_accession":"P40571","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/nucleolar-ribonuclease-p-complex-go0005655.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0005655","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/nucleolar-ribonuclease-p-complex-go0005655.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/ribonuclease-mrp-complex-go0000172.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0000172","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/ribonuclease-mrp-complex-go0000172.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/plasmid-partitioning-go0030541.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0030541","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/plasmid-partitioning-go0030541.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/rpr2-pf04032.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04032","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/rpr2-pf04032.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:P40993","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF04032"],"protein_name":"Ribonuclease MRP protein subunit SNM1","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"d0a12e44ff3b7886ed9c1b02e31e3485337892459e5ba847a968b8fbe679e8b7","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MNKDQAEKYQERSLRQKYNLLHVLPTLNSRALSGLYYKNFHNSVKRYQIMLPEQLKSGKFCSHCGCVYVPNFNASLQLTTNTEQGDSDELGGESMEGPKKCIQVNCLNCEKSKLFEWKSEFVVPTFGQDVSPMINSTSSGKVSYAVKKPQKSKTSTGKERSKKRKLNSLTNLLSKRNQEKKMEKKKSSSLSLESFMKS","sequence_length":198,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"d0a12e44ff3b7886ed9c1b02e31e3485337892459e5ba847a968b8fbe679e8b7","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P40993.json","taxon_id":"559292","uniprot_accession":"P40993","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/ribonuclease-p-complex-go0030677.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0030677","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/ribonuclease-p-complex-go0030677.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/ribonuclease-p-activity-go0004526.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0004526","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/ribonuclease-p-activity-go0004526.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/trna-5-leader-removal-go0001682.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0001682","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/trna-5-leader-removal-go0001682.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/rpr2-pf04032.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04032","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/rpr2-pf04032.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/6-20-50-20-6-20-50-20.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:6.20.50.20","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/6-20-50-20-6-20-50-20.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/immunoglobulin-fc-subunit-c-1-20-5-420.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:1.20.5.420","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/immunoglobulin-fc-subunit-c-1-20-5-420.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q58372","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF04032"],"protein_name":"Ribonuclease P protein component 4","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"ec4977455b475bd066da3fe58f2ea262e6ebed1eb543198ccfc9248dae81cc67","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MKKFLEKKLKKIAYERIDILMSLAEEEAKKGNWDRAKRYVYLARRIAMKMRIRFPKKWKRRICKKCGTFLLYGRNARVRIKSKRYPHVVITCLECGAIYRIPMIREKKEKRRKKLEERLKAKSNSQTS","sequence_length":128,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"ec4977455b475bd066da3fe58f2ea262e6ebed1eb543198ccfc9248dae81cc67","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q58372.json","taxon_id":"243232","uniprot_accession":"Q58372","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/rpr2-pf04032.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04032","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/rpr2-pf04032.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/6-20-50-20-6-20-50-20.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:6.20.50.20","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/6-20-50-20-6-20-50-20.yaml"}],"pfam_ids":["PF04032"],"protein_name":"Ribonuclease P protein subunit p21","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAGPVKDREAFQRLSFLYQAAHCVLSQNPENQALARFYCHTEKTIAKRLVLRQDPSVKRTLCRSCSSLLIPGLTCTQRQRRRKGQRWTVQTCLTCQRSQRFLNDPKHLLWGDRPEAQLENQADINPSEPLPNIADLPKENIQTQALNTSE","sequence_length":150,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"3d82bd5f9761b26db49edc6a40aafeb53a6202b5db92fcd60f641277c01f9981","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q8R040.json","taxon_id":"10090","uniprot_accession":"Q8R040","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/rpr2-pf04032.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04032","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/rpr2-pf04032.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/6-20-50-20-6-20-50-20.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:6.20.50.20","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/6-20-50-20-6-20-50-20.yaml"}],"pfam_ids":["PF04032"],"protein_name":"Ribonuclease P protein subunit p21","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAGPVKDREAFQRLNFLYQAAHCVLAQDPENQALARFYCYTERTIAKRLVLRRDPSVKRTLCRGCSSLLVPGLTCTQRQRRCRGQRWTVQTCLTCQRSQRFLNDPGHLLWGDRPEAQLGSQADSKPLQPLPNTAHSISDRLPEEKMQTQGSSNQ","sequence_length":154,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"85d98d09fbe865ab0c040ce5f47c36f9063394b65b2b6e0b115b94d92e70770f","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9H633.json","taxon_id":"9606","uniprot_accession":"Q9H633","uniprot_release":"2026_03"}],"pfam_id":"PF04032","short_name":"Rpr2","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}