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Verified PF04149/DUF397/InterPro:IPR007278 identity and all frozen counters, strict worklist and two-member manifest provenance, native FamilyRecord validation against synchronized schemas, and a full 6532-record baseline dry run with zero drift. The review finished at 2026-10-07T12:29:24Z against HEAD 611617feeda7ac0480898e7042bbd2fb4bdaf930 plus recorded working-tree inputs. No primary functional evidence was assessed and no biological claim, overlay, SEEDED status, or UNSCORED status was changed. The semantic digest before this bookkeeping append was b294554d93d69202f55e68bec9614b6f0b8c6abf544981c6548e2c347580ec35. The generated read-only event index will be refreshed separately through the native builder; this sidecar remains authoritative. This event records actual completed scoped review, not scientific endorsement or REVIEWED promotion.","event_index":0,"history_record":"history/records/PF04149/2026-10-07T122602Z-codex-3e2c16.yaml","llm_assisted":true,"local_source":"source/history/records/PF04149/2026-10-07T122602Z-codex-3e2c16.yaml","outcome":"no_change","source_path":"history/records/PF04149/2026-10-07T122602Z-codex-3e2c16.yaml","summary":"Completed a scoped PF04149 frozen-seed and native audit integration review; biological content unchanged.","timestamp":"2026-10-07T12:26:02Z","url":"https://github.com/CultureBotAI/DUFMech/blob/c8155abfcf881ad8662936343deb81e604e3a194/history/records/PF04149/2026-10-07T122602Z-codex-3e2c16.yaml"}],"local_source":"source/data/families/PF04149.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":19000,"domain_architectures":25,"matches":40691,"proteins":37657,"proteomes":1831,"structures":0,"taxa":2162},"curation_events":[{"action":"REVIEW","curator":"Codex","event_index":0,"history_record":"history/records/PF04149/2026-10-07T122602Z-codex-3e2c16.yaml","llm_assisted":true,"outcome":"no_change","summary":"Completed a scoped PF04149 frozen-seed and native audit integration review; biological content unchanged.","timestamp":"2026-10-07T12:26:02Z"}],"curation_status":"SEEDED","description":"The function of this family is unknown.","id":"Pfam:PF04149","interpro_id":"InterPro:IPR007278","name":"Domain of unknown function (DUF397)","pfam_id":"PF04149","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF397","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04149"},"reviews":[{"label":"2026-10-07T07:24:23.895662Z: SEED_ONLY by Codex (GPT-6), scoped implementation audit","local_source":"source/reports/yaml_category_review/20261007T072423Z-two-seed-provenance.md","scientific_review":false,"scope":"Two explicitly selected frozen rows: identity, evidence categories, and lump/split triage.","url":"https://github.com/CultureBotAI/DUFMech/blob/c8155abfcf881ad8662936343deb81e604e3a194/reports/yaml_category_review/20261007T072423Z-two-seed-provenance.md"},{"label":"2026-10-07T07:24:23.895662Z: SEED_ONLY by Codex (GPT-6), scoped implementation audit","local_source":"source/reports/yaml_record_review/20261007T072423Z-PF04149.md","scientific_review":false,"scope":"Frozen-row identity, source integrity, and evidence-completeness triage only.","url":"https://github.com/CultureBotAI/DUFMech/blob/c8155abfcf881ad8662936343deb81e604e3a194/reports/yaml_record_review/20261007T072423Z-PF04149.md"},{"label":"2026-10-07T08:06:30Z: SEED_ONLY by Codex (GPT-5 coding agent), independent scoped reviewer","local_source":"source/reports/yaml_record_review/20261007T080630Z-PF04149.md","scientific_review":false,"scope":"Offline identity, frozen-source provenance and generated-record integrity of candidate working-tree PF04149; no biological functional characterization or live-source verification.","url":"https://github.com/CultureBotAI/DUFMech/blob/c8155abfcf881ad8662936343deb81e604e3a194/reports/yaml_record_review/20261007T080630Z-PF04149.md"},{"label":"2026-10-07T12:29:24Z: SEED_ONLY by Codex (GPT-5 coding agent; scoped implementation reviewer)","local_source":"source/reports/yaml_record_review/20261007T122924Z-PF04149.md","scientific_review":false,"scope":"Offline PF04149 identity, frozen-input provenance, evidence inventory, and native schema/history-index integration audit; no live-source verification, functional literature review, or scientific endorsement.","url":"https://github.com/CultureBotAI/DUFMech/blob/c8155abfcf881ad8662936343deb81e604e3a194/reports/yaml_record_review/20261007T122924Z-PF04149.md"}],"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF04149.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"fad4dcca467436fa8f86bc36d01c6347ce9066e6b1a417d4410c3739b3805616"}},"protein_examples":{"candidate_count":0,"discovery_scanned":true,"example_count":0,"examples":[],"pfam_id":"PF04149","short_name":"DUF397","status":"NO_SIBLING_CANDIDATE","unresolved":[]}}