{"cross_mech":[],"family":{"alphafold_models":3078,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This is a family of putative bacterial lipoproteins necessary for the uptake of haem-iron. The structure of UniProtKB:Q0PBW2, PDB:2g5g, comprises a large parallel beta-sheet with flanking alpha-helices and a smaller domain consisting of alpha-helices. Two cofacial haem groups (~3.5 Angstom apart with an inter-iron distance of 4.4 Angstrom) bind in a pocket formed by a dimer of two ChaN monomers [[cite:PUB00075535],[cite:PUB00040938]].","domain_architectures":47,"interpro_id":"IPR007314","known_evidence_count":null,"matches":4567,"name":"Haem-binding uptake, Tiki superfamily, ChaN","partial_evidence_count":null,"pfam_id":"PF04187","proteins":4545,"proteomes":3958,"short_name":"Cofac_haem_bdg","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04187","structures":1,"taxa":6774,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF04187.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":3078,"domain_architectures":47,"matches":4567,"proteins":4545,"proteomes":3958,"structures":1,"taxa":6774},"curation_status":"SEEDED","description":"This is a family of putative bacterial lipoproteins necessary for the uptake of haem-iron. The structure of UniProtKB:Q0PBW2, PDB:2g5g, comprises a large parallel beta-sheet with flanking alpha-helices and a smaller domain consisting of alpha-helices. Two cofacial haem groups (~3.5 Angstom apart with an inter-iron distance of 4.4 Angstrom) bind in a pocket formed by a dimer of two ChaN monomers [[cite:PUB00075535],[cite:PUB00040938]].","id":"Pfam:PF04187","interpro_id":"InterPro:IPR007314","name":"Haem-binding uptake, Tiki superfamily, ChaN","pfam_id":"PF04187","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Cofac_haem_bdg","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04187"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF04187.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"988c9fd8a6068b8f60ada9f5ad107130ce18ade967fffbe6549981be51b04331"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Arabidopsis thaliana","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/chan-is-an-iron-regulated-heme-binding-protein-this-family-represents--cd14727.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd14727","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/chan-is-an-iron-regulated-heme-binding-protein-this-family-represents--cd14727.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/haem-binding-uptake-tiki-superfamily-chan-ipr007314.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR007314","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/haem-binding-uptake-tiki-superfamily-chan-ipr007314.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/cofac-haem-bdg-pf04187.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04187","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/cofac-haem-bdg-pf04187.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/reticulata-like-pf11891.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF11891","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/reticulata-like-pf11891.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/3-40-50-11550-3-40-50-11550.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:3.40.50.11550","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/3-40-50-11550-3-40-50-11550.yaml"}],"pfam_ids":["PF04187","PF11891"],"protein_name":"Protein RETICULATA-RELATED 6, chloroplastic","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKLTTNDLFASQPLFHCPCSSSSRPRRRRFYGLHFPINLTSEKNNSLSIVALSDSDLPSRTAFSRRAFLLAPPLLVSAASLFLKPSVSLASEESSSATVTSPAESAAPPPPPATTTPSPPPPVNKEETITSRIYDATAIGEPMAMGKDKKKVWEKLLNARVVYLGEAEQVPTKDDKELELEIVRNLRKRCVESERQISVALEAFPLDLQDQLNQYMDKRMDGETLKSYVTHWPAQRWQEYEPLLSYCRDNSVRLIACGTPLKVLRTVQAEGIRGLSKSERKLYTPPAGSGFISGFSSFSRRSTFDMSLPTQIVPFGPSSYLSAQARVVEDHTMSQVILQAVADGGGTGLLLVVTGASHVEYGSRGTGLPARISRKFPKKNQVVVLLDPERQFLRREGETPVADFLWYSAARPCSRNCFDRAEIARVMNAAGRRRDALPPDIQNGLDLGLVSPEVLQNLFDLEQYPLISELTQRFQGFRERLLADPKFLNRLAIEEAISITTTLIAQYEKRKENFFEEIDYVITDTVRGSVVDFFTVWLPAPTLSFLSYADETTGPDSIDALRGLLGSIPDNAFQKSLAGREWNLNLRIASVIVGGLKLAGVGVVSSFAAVGASNALNIARKVIKPELVVAEKPKRSPLLKTAMVYGGFLGTSANLRYQIIAGLIEHRLSDELSSQPLLVNAISFVVRTLNSYFGTQQWIDLARSTGLQTQKSIPASKEISEALEEPTVECDTTTEEESIDKLNNQ","sequence_length":745,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"373f3419924766a65f67d3f3c6f7a671456fe3f0672eb6b21d581064a1a26abe","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8RWG3.json","taxon_id":"3702","uniprot_accession":"Q8RWG3","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Arabidopsis thaliana","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/chan-is-an-iron-regulated-heme-binding-protein-this-family-represents--cd14727.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd14727","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/chan-is-an-iron-regulated-heme-binding-protein-this-family-represents--cd14727.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/haem-binding-uptake-tiki-superfamily-chan-ipr007314.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR007314","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/haem-binding-uptake-tiki-superfamily-chan-ipr007314.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/cofac-haem-bdg-pf04187.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04187","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/cofac-haem-bdg-pf04187.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/reticulata-like-pf11891.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF11891","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/reticulata-like-pf11891.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/3-40-50-11550-3-40-50-11550.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:3.40.50.11550","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/3-40-50-11550-3-40-50-11550.yaml"}],"pfam_ids":["PF04187","PF11891"],"protein_name":"Protein RETICULATA-RELATED 5, chloroplastic","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKPTTNGGLLASQSSSSFSFPRFRGQLPIIFSANNNQKKKNLPNPNVVTLCLHSHSNVSSSQIAVTRRAILVAPPLLAAAASLFLSISSAASAETSAESVALPPVATAPPPPPVEKEEAITSRIYDASVLGEPMAVGKDKKRVWEKLLNARIVYLGEAEQVPTRDDKVLELEIVRNLRKRCIESDRQLSLALEAFPLDLQEQLNQYMDKRMDGEVLKSYVSHWPVQRWQEYEPLLSYCRDNGVKLIACGTPLKVLRTVQAEGIRGLSESERKLYTPPAGSGFISGFTSFSRSSSLNMNPLTQIVPFGPSSYLSAQARVVEDHTMSQVIVQAVADGGGTGMLVVVTGANHVEYGSRGTGLPARISRKIPKKSQLVVLLDPERQFLRKEGESPVADFLWYSAARPCSRNCFDRAEIARVMNAAGRRRDALPQDIQKGLDLGLVSPEILQNFFDLEQYPLISELTQRFQGFRERLLADPKFLNRLAIEEAISITTTLVAQYEKRKENFFEELDYVITDSVRASVVDFFTVWLPAPTLSFISYADETIGPNSIDALRGLLGSIPDNAFQKSLGGQEWTLSLRIASVIIGGLKLAGVGVVSSFAAVGSSNALYAIRKFIKPELGVGEQAKRSPMLKTALVYGGYLGTSSNIRYQIIAGLIEHRISDELSSQPLLVNMISFVVRVANSYFGTQQWIDLARSTGLQTQKSVTTSNQIPEVASQSTVEYSTTEEASMDDLKNQ","sequence_length":735,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"cf5e135f4503a647aa4751f6e15514138b85080e581d4c70a585e91971032b35","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9SIY5.json","taxon_id":"3702","uniprot_accession":"Q9SIY5","uniprot_release":"2026_03"}],"pfam_id":"PF04187","short_name":"Cofac_haem_bdg","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
