{"cross_mech":[],"family":{"alphafold_models":3516,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"In budding yeast, Get4 is part of the GET complex that inserts the tail-anchored (TA) proteins into the endoplasmic reticulum membrane [[cite:PUB00092561],[cite:PUB00092562]]. In humans, Get4 is part the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and facilitates their proper delivery to the endoplasmic reticulum, or alternatively promotes their sorting to the proteasome where they undergo degradation [[cite:PUB00092560],[cite:PUB00086005],[cite:PUB00086007],[cite:PUB00086008]]. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane [[cite:PUB00092560],[cite:PUB00086008],[cite:PUB00092563]].","domain_architectures":66,"interpro_id":"IPR007317","known_evidence_count":null,"matches":4204,"name":"Golgi to ER traffic protein 4","partial_evidence_count":null,"pfam_id":"PF04190","proteins":4116,"proteomes":3267,"short_name":"GET4","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04190","structures":11,"taxa":8653,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF04190.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":3516,"domain_architectures":66,"matches":4204,"proteins":4116,"proteomes":3267,"structures":11,"taxa":8653},"curation_status":"SEEDED","description":"In budding yeast, Get4 is part of the GET complex that inserts the tail-anchored (TA) proteins into the endoplasmic reticulum membrane [[cite:PUB00092561],[cite:PUB00092562]]. In humans, Get4 is part the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and facilitates their proper delivery to the endoplasmic reticulum, or alternatively promotes their sorting to the proteasome where they undergo degradation [[cite:PUB00092560],[cite:PUB00086005],[cite:PUB00086007],[cite:PUB00086008]]. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane [[cite:PUB00092560],[cite:PUB00086008],[cite:PUB00092563]].","id":"Pfam:PF04190","interpro_id":"InterPro:IPR007317","name":"Golgi to ER traffic protein 4","pfam_id":"PF04190","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"GET4","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04190"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF04190.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"0b9a659fe7d22348b16685478299cb235859f37c6226fb060a1af0b5cdd8d27c"}},"protein_examples":{"candidate_count":5,"discovery_scanned":true,"example_count":5,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/trc-complex-go0072380.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0072380","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/trc-complex-go0072380.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/repeat/pfam/get4-pf04190.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04190","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/repeat/pfam/get4-pf04190.yaml"}],"pfam_ids":["PF04190"],"protein_name":"Golgi to ER traffic protein 4","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MVPAESNAVQAKLAKTLQRFENKIKAGDYYEAHQTLRTIANRYVRSKSYEHAIELISQGALSFLKAKQGGSGTDLIFYLLEVYDLAEVKVDDISVARLVRLIAELDPSEPNLKDVITGMNNWSIKFSEYKFGDPYLHNTIGSKLLEGDFVYEAERYFMLGTHDSMIKYVDLLWDWLCQVDDIEDSTVAEFFSRLVFNYLFISNISFAHESKDIFLERFIEKFHPKYEKIDKNGYEIVFFEDYSDLNFLQLLLITCQTKDKSYFLNLKNHYLDFSQAYKSELEFLGQEYFNIVAPKQTNFLQDMMSGFLGGSK","sequence_length":312,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"d2989afb5590ff4aa1e3415924616bfd61c49d381458b68e23d85fc4c2d08844","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q12125.json","taxon_id":"559292","uniprot_accession":"Q12125","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Arabidopsis thaliana","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/repeat/pfam/get4-pf04190.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04190","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/repeat/pfam/get4-pf04190.yaml"}],"pfam_ids":["PF04190"],"protein_name":"Protein GET4","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSRERIKRELPPVQEHIDKLRKVIEEGNYYGALQMYKSISARYVTAQRFSEALDILFSGACIELEHGLVNCGADLAILFVDTLVKAKSPCNDETLDRIRCIFKLFPRVPVPPHLVDVSDDEDVQNLQESLGEARSRVENLTSFLRAAIKWSAEFGGPRTGYPELHAMLGDYLYTECPELDMVRISRHFVRAEDPEKFASMLVNFMGRCYPGEDDLAIARAVLMYLSMGNMKDANFMMDEIKKQAETKNPELSESDLIQFISYLLETLQRDALPLFNMLRVKYKSSIDRDQLLNELLDEIAERFYGVQRKNPLQGMFGDIFKMMG","sequence_length":324,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"8cb020229603499505c02005d05eee581104b1bf11e7f22b58b39a316850757c","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q6GKV1.json","taxon_id":"3702","uniprot_accession":"Q6GKV1","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/bat3-complex-go0071818.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0071818","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/bat3-complex-go0071818.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/repeat/pfam/get4-pf04190.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04190","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/repeat/pfam/get4-pf04190.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q7L5D6","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF04190"],"protein_name":"Golgi to ER traffic protein 4 homolog","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"8307aa7198944f85444080319a797d92e23fa89756f7420954cde1f02c17de3f","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MAAAAAMAEQESARNGGRNRGGVQRVEGKLRASVEKGDYYEAHQMYRTLFFRYMSQSKHTEARELMYSGALLFFSHGQQNSAADLSMLVLESLEKAEVEVADELLENLAKVFSLMDPNSPERVTFVSRALKWSSGGSGKLGHPRLHQLLALTLWKEQNYCESRYHFLHSADGEGCANMLVEYSTSRGFRSEVDMFVAQAVLQFLCLKNKSSASVVFTTYTQKHPSIEDGPPFVEPLLNFIWFLLLAVDGGKLTVFTVLCEQYQPSLRRDPMYNEYLDRIGQLFFGVPPKQTSSYGGLLGNLLTSLMGSSEQEDGEESPSDGSPIELD","sequence_length":327,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"8307aa7198944f85444080319a797d92e23fa89756f7420954cde1f02c17de3f","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q7L5D6.json","taxon_id":"9606","uniprot_accession":"Q7L5D6","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/bat3-complex-go0071818.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0071818","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/bat3-complex-go0071818.yaml"}],"pfam_ids":["PF04190"],"protein_name":"Golgi to ER traffic protein 4 homolog","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAAAAAMAEQEGARNGARNRGGVQRVEGKLRASVEKGDYYEAHQMYRTLFFRYMSQSKHAEARELMYSGALLFFSHGQQNSAADLSMLVLESLEKAEVDVADELLENLAKVFSLMDPNSPERVAFVSRALKWSSGGSGKLGHPRLHQLLALTLWKEQNYCESRYHFLHSSDGEGCANMLVEYSTARGFRSEVDMFVAQAVLQFLCLKNKNSALVVFTTYTQKHPSIEDGPPFVQPLLNFIWFLLLAVDGGKLAVFTVLCEQYQPSLRRDPMYNEYLDRIGQLFFGVPPKQTSSYGGLLGNLLSSLMGSSEQEEGEESQDDSSPIELD","sequence_length":327,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"eb2f6731a453e7883fed06448985bf1172d5c2c25f0ab8901f454f0403e0c94c","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q9D1H7.json","taxon_id":"10090","uniprot_accession":"Q9D1H7","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Drosophila melanogaster","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/bat3-complex-go0071818.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0071818","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/bat3-complex-go0071818.yaml"}],"pfam_ids":["PF04190"],"protein_name":"Golgi to ER traffic protein 4 homolog","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSAAETGPIASGSAVSTGQRGVSRVLAKLSQSLAGGEFYEAHMMYRTLYFRYTAQKRYQDCLELLFDGAQQLIAKEQESSAADLCLLLVDTLEKRGPQAEDTDNFLWVPRLGALIRGLNSATVERETLIQRTIKWSTALHGQYGHPVLHKLIAHVFWTEGNIESARHHYLLCQDGSLCGRVLIEISQSRGFQGEMDLFLVQAVLQQLSLKDRKTAEDTFTEYTRYHAKLLKHEFPYKEPLVNFLYFLFRLIDAKRVAGFRALRKLYDPSLKRDTSFLKYVAKIGVLYFDEHPEAAHSGPPGLGGMFGDIFNRLMAGFEEDDADDHDTTLRRQNENNELE","sequence_length":339,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"2b6a58ccf7d09e016035fd826446489879b4bf8587fdc4369646f38693c17a7c","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9VN19.json","taxon_id":"7227","uniprot_accession":"Q9VN19","uniprot_release":"2026_03"}],"pfam_id":"PF04190","short_name":"GET4","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}