{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF04217","protein_label":"UPF0208 membrane protein YfbV","reviewed":true,"short_name":"DUF412","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/negative-regulation-of-chromosome-organization-go2001251.yaml","source_record_id":"GO:2001251","source_record_label":"negative regulation of chromosome organization","source_section":"canonical_examples","taxon_id":"NCBITaxon:83333","taxon_label":"Escherichia coli (strain K12)","uniprot_accession":"P0A8D9","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF04217","protein_label":"UPF0208 membrane protein YfbV","reviewed":true,"short_name":"DUF412","source_category":"function/protein_family/ncbifam","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/protein_family/ncbifam/terminus-macrodomain-insulation-protein-yfbv-nf002493.yaml","source_record_id":"NCBIfam:NF002493","source_record_label":"terminus macrodomain insulation protein YfbV","source_section":"canonical_examples","taxon_id":"NCBITaxon:83333","taxon_label":"Escherichia coli (strain K12)","uniprot_accession":"P0A8D9","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF04217","protein_label":"UPF0208 membrane protein YfbV","reviewed":true,"short_name":"DUF412","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf412-pf04217.yaml","source_record_id":"Pfam:PF04217","source_record_label":"Protein of unknown function, DUF412","source_section":"canonical_examples","taxon_id":"NCBITaxon:83333","taxon_label":"Escherichia coli (strain K12)","uniprot_accession":"P0A8D9","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF04217","protein_label":"UPF0208 membrane protein YfbV","reviewed":true,"short_name":"DUF412","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf412-pf04217.yaml","source_record_id":"Pfam:PF04217","source_record_label":"Protein of unknown function, DUF412","source_section":"canonical_examples","taxon_id":"NCBITaxon:295319","taxon_label":"Salmonella paratyphi A (strain ATCC 9150 / SARB42)","uniprot_accession":"Q5PN46","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF04217","protein_label":"UPF0208 membrane protein YfbV","reviewed":true,"short_name":"DUF412","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf412-pf04217.yaml","source_record_id":"Pfam:PF04217","source_record_label":"Protein of unknown function, DUF412","source_section":"canonical_examples","taxon_id":"NCBITaxon:199310","taxon_label":"Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)","uniprot_accession":"Q8FFJ2","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF04217","protein_label":"","reviewed":null,"short_name":"DUF412","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf412-pf04217.yaml","source_record_id":"Pfam:PF04217","source_record_label":"Protein of unknown function, DUF412","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":852,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":3,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":3},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family consists of bacterial proteins, including yfbV from E. coli. YfbV is a membrane protein involved in insulating the chromosome from the TerR macrodomain [[cite:PUB00104115]].","domain_architectures":1,"interpro_id":"IPR007334","known_evidence_count":null,"matches":1295,"name":"Protein of unknown function, DUF412","partial_evidence_count":null,"pfam_id":"PF04217","proteins":1295,"proteomes":1250,"short_name":"DUF412","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04217","structures":0,"taxa":1757,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF04217.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":852,"domain_architectures":1,"matches":1295,"proteins":1295,"proteomes":1250,"structures":0,"taxa":1757},"curation_status":"SEEDED","description":"This family consists of bacterial proteins, including yfbV from E. coli. YfbV is a membrane protein involved in insulating the chromosome from the TerR macrodomain [[cite:PUB00104115]].","id":"Pfam:PF04217","interpro_id":"InterPro:IPR007334","name":"Protein of unknown function, DUF412","pfam_id":"PF04217","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF412","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04217"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF04217.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"35d45d00fffa1f3621c8186a90d39f43c71039ef4a3880947da8df06c030cd62"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli (strain K12)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/negative-regulation-of-chromosome-organization-go2001251.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:2001251","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/negative-regulation-of-chromosome-organization-go2001251.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/protein_family/ncbifam/terminus-macrodomain-insulation-protein-yfbv-nf002493.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:NF002493","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/protein_family/ncbifam/terminus-macrodomain-insulation-protein-yfbv-nf002493.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf412-pf04217.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04217","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf412-pf04217.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:P0A8D9","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF04217"],"protein_name":"UPF0208 membrane protein YfbV","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"66a443c77d1b8a38e2ab01d6b52732c178f1815ff0617ffc224341170de33440","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MSTPDNRSVNFFSLFRRGQHYSKTWPLEKRLAPVFVENRVIKMTRYAIRFMPPIAVFTLCWQIALGGQLGPAVATALFALSLPMQGLWWLGKRSVTPLPPAILNWFYEVRGKLQESGQVLAPVEGKPDYQALADTLKRAFKQLDKTFLDDL","sequence_length":151,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"66a443c77d1b8a38e2ab01d6b52732c178f1815ff0617ffc224341170de33440","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P0A8D9.json","taxon_id":"83333","uniprot_accession":"P0A8D9","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Salmonella paratyphi A (strain ATCC 9150 / SARB42)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf412-pf04217.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04217","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf412-pf04217.yaml"}],"pfam_ids":["PF04217"],"protein_name":"UPF0208 membrane protein YfbV","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSTPDNRSVNFFSLFRRGQHYAKTWPMEKRLAPVFVENRVIRMTRYAIRFMPPVAVFTLCWQIALGGQLGPAVATALFALSLPMQGLWWLGKRSVTPLPPSILNWFYEVRGKLQEAGQALAPVEGKPDYQALADTLKRAFKQLDKTFLDDL","sequence_length":151,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"9340d855e0187456b2cad4b1917a95ea2dbc66b15ea42f890ecf7583e8516951","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q5PN46.json","taxon_id":"295319","uniprot_accession":"Q5PN46","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf412-pf04217.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04217","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf412-pf04217.yaml"}],"pfam_ids":["PF04217"],"protein_name":"UPF0208 membrane protein YfbV","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSTPDNRSVNFFSLFCRGQHYSKTWPLEKRLAPVFVENRVIKMTRYAIRFMPPIAVFTLCWQIALGGQLGPAVATALFALSLPMQGLWWLGKRSVTPLPPAILNWFYEVRGKLQESGQVLAPVEGKPDYQALADTLKRAFKQLDKTFLDDL","sequence_length":151,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"4829b828c65e8a6c710d562abea02ef26de5e341b7b842f0dced9bf174e27c47","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8FFJ2.json","taxon_id":"199310","uniprot_accession":"Q8FFJ2","uniprot_release":"2026_03"}],"pfam_id":"PF04217","short_name":"DUF412","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
