{"cross_mech":[],"family":{"alphafold_models":1360,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family of proteins includes Protein arginine N-methyltransferase SFM1 from Saccharomyces cerevisiae and similar proteins from fungi and archaea. Sfm1 is a S-adenosyl-L-methionine-dependent protein- arginine N-methyltransferase that monomethylates ribosomal protein S3 (RPS3) at 'Arg-146' [[cite:PUB00075405]].","domain_architectures":27,"interpro_id":"IPR007364","known_evidence_count":null,"matches":1631,"name":"Protein arginine N-methyltransferase SFM1-like","partial_evidence_count":null,"pfam_id":"PF04252","proteins":1605,"proteomes":1517,"short_name":"SFM1-like","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04252","structures":5,"taxa":3206,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF04252.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1360,"domain_architectures":27,"matches":1631,"proteins":1605,"proteomes":1517,"structures":5,"taxa":3206},"curation_status":"SEEDED","description":"This family of proteins includes Protein arginine N-methyltransferase SFM1 from Saccharomyces cerevisiae and similar proteins from fungi and archaea. Sfm1 is a S-adenosyl-L-methionine-dependent protein- arginine N-methyltransferase that monomethylates ribosomal protein S3 (RPS3) at 'Arg-146' [[cite:PUB00075405]].","id":"Pfam:PF04252","interpro_id":"InterPro:IPR007364","name":"Protein arginine N-methyltransferase SFM1-like","pfam_id":"PF04252","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"SFM1-like","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04252"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF04252.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"3ad73a5ff975dc74f2a5aee7163edfbe073b23c0023f37b52c5c927e7c3b57aa"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/sam-dependent-arginine-methyltransferase-related-to-yeast-sfm1-arginin-cd18090.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd18090","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/sam-dependent-arginine-methyltransferase-related-to-yeast-sfm1-arginin-cd18090.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/sfm1-like-pf04252.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04252","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/sfm1-like-pf04252.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q12314","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF04252"],"protein_name":"Protein arginine N-methyltransferase SFM1","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"594eb49eed5ac67fe83c7ea8e07cf590f893f3c9014ed1b32a4bac5747cc7208","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MKYIIEHMEEGFSEWVILEYSQILREVGAENLILSSLPESTTEKDIPQRLLKLGLRWTTKDLKGINEDFKDLELLKDGRVCLLDPRATIDLQPEDATKFDYFVFGGILGDHPPRDRTKELKTAYPNLLISRRLGDKQMTTDTAIRTTQLIIKDRIAFEDIKFIDYPEFRFNKNEATEMPFRYVLDKEGKPILPEGMLDLIKKDSAQSLDDLLM","sequence_length":213,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"594eb49eed5ac67fe83c7ea8e07cf590f893f3c9014ed1b32a4bac5747cc7208","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q12314.json","taxon_id":"559292","uniprot_accession":"Q12314","uniprot_release":"2026_03"}],"pfam_id":"PF04252","short_name":"SFM1-like","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}