{"cross_mech":[],"family":{"alphafold_models":546,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This is a family of proteins that are archaea-specific components of the bacterial-like chemotaxis signal transduction system of archaea. In H. salinarum, the CheF proteins interact with the chemotaxis proteins CheY, CheD and CheC2 as well as the flagella-accessory proteins FlaCE and FlaD, and are essential for any tactic response. CheF probably functions at the interface between the bacterial-like chemotaxis signal transduction system and the archaeal flagellar apparatus. This region is predicted to contain a tandem of two PH-like domains.","domain_architectures":3,"interpro_id":"IPR007381","known_evidence_count":null,"matches":591,"name":"Archaeal Chemotaxis signal transduction system protein F","partial_evidence_count":null,"pfam_id":"PF04283","proteins":591,"proteomes":270,"short_name":"CheF-arch","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04283","structures":1,"taxa":468,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF04283.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":546,"domain_architectures":3,"matches":591,"proteins":591,"proteomes":270,"structures":1,"taxa":468},"curation_status":"SEEDED","description":"This is a family of proteins that are archaea-specific components of the bacterial-like chemotaxis signal transduction system of archaea. In H. salinarum, the CheF proteins interact with the chemotaxis proteins CheY, CheD and CheC2 as well as the flagella-accessory proteins FlaCE and FlaD, and are essential for any tactic response. CheF probably functions at the interface between the bacterial-like chemotaxis signal transduction system and the archaeal flagellar apparatus. This region is predicted to contain a tandem of two PH-like domains.","id":"Pfam:PF04283","interpro_id":"InterPro:IPR007381","name":"Archaeal Chemotaxis signal transduction system protein F","pfam_id":"PF04283","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"CheF-arch","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04283"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF04283.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"cada527bc4970cd9e36a1b17e91a0eb63e613ea878a3039335e6fb2a7d580134"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/chef-arch-pf04283.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04283","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/chef-arch-pf04283.yaml"}],"pfam_ids":["PF04283","PF29648"],"protein_name":"Taxis protein CheF1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSESEYKIADGSGKFLQAVKDGRRMKDAQWSKGRILLSNKRIVLAGSEGKRNLPLSEVQGLSGRHDVNQTVAKVGNYVSIRMTNESVMLVSLGDNTETFESKLYGALLDQTELQVKHPAVEGGVVTDEQFERARIKVDESELSVAMSNGSFVSVELDDVGSAEAASLEVNGDTKPVLKVEHTVNRDTSVQTYFATDSHTASILESLLTKEAEKSQGSVELSETEKRVLMALYSGVSSFEIPDFLGMDVDEVESIFERLIEVDVLEEVRKRREVTMKTRGRNIASEAINEE","sequence_length":290,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"cc3e9eda218e8875f56eae63c6096862c4a955184a023372c1e0eb152b6ff7e7","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/B0R4J3.json","taxon_id":"478009","uniprot_accession":"B0R4J3","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/chef-arch-pf04283.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04283","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/chef-arch-pf04283.yaml"}],"pfam_ids":["PF04283"],"protein_name":"Taxis protein CheF2","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSESAIADFVSSFIPDTATHVEPVRGRVVMSKRRIVLAADDEKTTIPLNGVFDVQHETAPGDLARFFEDTVTIAYEHDEDRHVAVIEGGGSTVDRFVTLVFKALVHGTTVYAKHPARRGGRITDQPFEKGNLALSPGDLTITGDADTTIDLSTVSHFERVDREVNGSNKQLLSVRHMGSTGPITTELALSSGRKMNLLGRYIRLQYTHLKQELADVTLTSEEIEALVAIYSSGPNASLAAVLGVDASRVTMLLNDLIEKELVTDDDGIALTSLGRAAVSEHIEDVNL","sequence_length":287,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"e24c34b12b0d694d530ee4e12807bb9fa6ee3e1a41b73e58a1c5c9bddb955799","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/B0R4J4.json","taxon_id":"478009","uniprot_accession":"B0R4J4","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/chef-arch-pf04283.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04283","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/chef-arch-pf04283.yaml"}],"pfam_ids":["PF04283"],"protein_name":"CheF taxis protein family member MJ1615","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MIDKSSEIARFSGKGILITPKTLEKPLLKWEKLEIILYKDKIVFEFVDKTIEVGVEDIEDVGAELPKKVIDIAKSTLEDITYHSSIIIKSKEFGNVMVGFAPETSIYGKAPIDNFLRKLFYILLNKKEVKILYNAGENSENTKWENGFLTFIKKRIKDGLVTKIEYRLVVEILDNEDSKIYDIFSNIKDVEIEEKDVDGEIEPVLKILQVKDGKDIISYLYTKDKKVRLFILRYMVILLDYKYIGILRYLQETVE","sequence_length":255,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"7607616c36f8f3dd8eddcd98a0cfe514efdfa54f39c447583b2a676df3761522","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q59010.json","taxon_id":"243232","uniprot_accession":"Q59010","uniprot_release":"2026_03"}],"pfam_id":"PF04283","short_name":"CheF-arch","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
