{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF04284","protein_label":"UPF0756 membrane protein YeaL","reviewed":true,"short_name":"DUF441","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf441-pf04284.yaml","source_record_id":"Pfam:PF04284","source_record_label":"Protein of unknown function (DUF441)","source_section":"canonical_examples","taxon_id":"NCBITaxon:41514","taxon_label":"Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)","uniprot_accession":"A9MFI4","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF04284","protein_label":"UPF0756 membrane protein YtwI","reviewed":true,"short_name":"DUF441","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf441-pf04284.yaml","source_record_id":"Pfam:PF04284","source_record_label":"Protein of unknown function (DUF441)","source_section":"canonical_examples","taxon_id":"NCBITaxon:224308","taxon_label":"Bacillus subtilis (strain 168)","uniprot_accession":"O34811","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF04284","protein_label":"UPF0756 membrane protein YeaL","reviewed":true,"short_name":"DUF441","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf441-pf04284.yaml","source_record_id":"Pfam:PF04284","source_record_label":"Protein of unknown function (DUF441)","source_section":"canonical_examples","taxon_id":"NCBITaxon:83333","taxon_label":"Escherichia coli (strain K12)","uniprot_accession":"P0ACY6","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF04284","protein_label":"","reviewed":null,"short_name":"DUF441","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf441-pf04284.yaml","source_record_id":"Pfam:PF04284","source_record_label":"Protein of unknown function (DUF441)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":1496,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":3,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":1},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"Predicted to be an integral membrane protein.","domain_architectures":3,"interpro_id":"IPR007382","known_evidence_count":null,"matches":2207,"name":"Protein of unknown function (DUF441)","partial_evidence_count":null,"pfam_id":"PF04284","proteins":2207,"proteomes":1960,"short_name":"DUF441","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04284","structures":0,"taxa":2964,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF04284.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1496,"domain_architectures":3,"matches":2207,"proteins":2207,"proteomes":1960,"structures":0,"taxa":2964},"curation_status":"SEEDED","description":"Predicted to be an integral membrane protein.","id":"Pfam:PF04284","interpro_id":"InterPro:IPR007382","name":"Protein of unknown function (DUF441)","pfam_id":"PF04284","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF441","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04284"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF04284.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"29227c9c86d1eb78611af50909ab9796876038fd56843e847f609d9dc3178904"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf441-pf04284.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04284","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf441-pf04284.yaml"}],"pfam_ids":["PF04284"],"protein_name":"UPF0756 membrane protein YeaL","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MFDVTLLILLGLAALGFISHNTTVAVSILVLIIVRVTPLNTFFPWIEKQGLTVGIIILTIGVMAPIASGTLPSSTLLHSFENWKSLVAIAVGVFVSWLGGRGVALMGNQPQLVAGLLVGTVLGVALFRGVPVGPLIAAGLVSLIVGRQ","sequence_length":148,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"34fcd8182e39b700029a660cedcb54f99803b873045ef7112ed5fde8bb3f25c1","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/A9MFI4.json","taxon_id":"41514","uniprot_accession":"A9MFI4","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Bacillus subtilis (strain 168)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf441-pf04284.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04284","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf441-pf04284.yaml"}],"pfam_ids":["PF04284"],"protein_name":"UPF0756 membrane protein YtwI","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MFTQANLFLILLLAIALIAKNQSLLFAVSVLLIIKIVGLDQKLFPTIQSKGINWGVTIITIAVLVPIATGEIGFKQLGEAMRSSYAWIALGAGIAVALIAKNGLTLLENDPHITTALVIGTILAVALFGGVAVGPLIGAGIAYLAMQIVKLFTS","sequence_length":154,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"0e410b77f46511231b5b19c79d8d1e7cc9775663a76441195710a3747de35100","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/O34811.json","taxon_id":"224308","uniprot_accession":"O34811","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli (strain K12)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf441-pf04284.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04284","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf441-pf04284.yaml"}],"pfam_ids":["PF04284"],"protein_name":"UPF0756 membrane protein YeaL","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MFDVTLLILLGLAALGFISHNTTVAVSILVLIIVRVTPLSTFFPWIEKQGLSIGIIILTIGVMAPIASGTLPPSTLIHSFLNWKSLVAIAVGVIVSWLGGRGVTLMGSQPQLVAGLLVGTVLGVALFRGVPVGPLIAAGLVSLIVGKQ","sequence_length":148,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"02a83bee1d8971bafebc15d1515f546600d82ce2943fa0a4ce0e660b152e3846","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P0ACY6.json","taxon_id":"83333","uniprot_accession":"P0ACY6","uniprot_release":"2026_03"}],"pfam_id":"PF04284","short_name":"DUF441","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
