{"cross_mech":[],"family":{"alphafold_models":1135,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family catalyses the final step in the elongation factor P modification pathway. It hydroxylates Lys-34 of elongation factor P [[cite:PUB00109139]]. Members of this family have a conserved HEXXH motif, suggesting they are putative peptidases of zincin fold [[cite:PUB00075429]].","domain_architectures":3,"interpro_id":"IPR007411","known_evidence_count":null,"matches":1795,"name":"Elongation factor P hydroxylase","partial_evidence_count":null,"pfam_id":"PF04315","proteins":1795,"proteomes":1777,"short_name":"EpmC","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04315","structures":2,"taxa":2428,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF04315.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1135,"domain_architectures":3,"matches":1795,"proteins":1795,"proteomes":1777,"structures":2,"taxa":2428},"curation_status":"SEEDED","description":"This family catalyses the final step in the elongation factor P modification pathway. It hydroxylates Lys-34 of elongation factor P [[cite:PUB00109139]]. Members of this family have a conserved HEXXH motif, suggesting they are putative peptidases of zincin fold [[cite:PUB00075429]].","id":"Pfam:PF04315","interpro_id":"InterPro:IPR007411","name":"Elongation factor P hydroxylase","pfam_id":"PF04315","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"EpmC","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04315"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF04315.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"edff7375684a1a2d65988373f610a3cf5ed98ebd7cb815829a9de920dc5ad1fa"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/epmc-pf04315.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04315","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/epmc-pf04315.yaml"}],"pfam_ids":["PF04315"],"protein_name":"Elongation factor P lysine hydroxylase","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MEHKLEDIIAIFNQCFEEEYNTRLVKGGDEPIYLPANDEVPYNAIYFARGFYSSALHEIAHWLVAGKERRKLEDFGYWYEPDGRSEERQRDFEKVEVKPQALEWILATAAGFRYFASADNLNGNPGDTQPFKQAVYEQVKIYAEKGLPKRAETLRKALVAFYSTEDDINLAKFDVTCI","sequence_length":178,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"52dd33f073cd5ec4abe60705224d92a37b5f4f2782124ab3dcc52061742e0e5c","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P44255.json","taxon_id":"71421","uniprot_accession":"P44255","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli (strain K12)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/epmc-pf04315.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04315","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/epmc-pf04315.yaml"}],"pfam_ids":["PF04315"],"protein_name":"Elongation factor P lysine hydroxylase","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MNSTHHYEQLIEIFNSCFADDFNTRLIKGDDEPIYLPADAEVPYNRIVFAHGFYASAIHEISHWCIAGKARRELVDFGYWYCPDGRDAQTQSQFEDVEVKPQALDWLFCVAAGYPFNVSCDNLEGDFEPDRVVFQRRVHAQVMDYLTNGIPERPARFIKALQNYYHTPELTAEQFPWPEALN","sequence_length":182,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"f79c9c4df1a0d16e64b61a3bc206743d3ead653d3822fe34568a99e36b12de62","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/P76938.json","taxon_id":"83333","uniprot_accession":"P76938","uniprot_release":"2026_03"}],"pfam_id":"PF04315","short_name":"EpmC","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
