{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF04367","protein_label":"Protein CONTINUOUS VASCULAR RING 1","reviewed":true,"short_name":"DUF502","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/stem-vascular-tissue-pattern-formation-go0010222.yaml","source_record_id":"GO:0010222","source_record_label":"stem vascular tissue pattern formation","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"F4IUE7","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF04367","protein_label":"Protein LIKE COV 1","reviewed":true,"short_name":"DUF502","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/stem-vascular-tissue-pattern-formation-go0010222.yaml","source_record_id":"GO:0010222","source_record_label":"stem vascular tissue pattern formation","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q8VY49","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF04367","protein_label":"Protein LIKE COV 2","reviewed":true,"short_name":"DUF502","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/stem-vascular-tissue-pattern-formation-go0010222.yaml","source_record_id":"GO:0010222","source_record_label":"stem vascular tissue pattern formation","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9C8C1","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF04367","protein_label":"Protein CONTINUOUS VASCULAR RING 1","reviewed":true,"short_name":"DUF502","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf502-pf04367.yaml","source_record_id":"Pfam:PF04367","source_record_label":"Protein of unknown function (DUF502)","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"F4IUE7","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF04367","protein_label":"Protein LIKE COV 1","reviewed":true,"short_name":"DUF502","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf502-pf04367.yaml","source_record_id":"Pfam:PF04367","source_record_label":"Protein of unknown function (DUF502)","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q8VY49","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF04367","protein_label":"Protein LIKE COV 2","reviewed":true,"short_name":"DUF502","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf502-pf04367.yaml","source_record_id":"Pfam:PF04367","source_record_label":"Protein of unknown function (DUF502)","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9C8C1","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF04367","protein_label":"","reviewed":null,"short_name":"DUF502","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf502-pf04367.yaml","source_record_id":"Pfam:PF04367","source_record_label":"Protein of unknown function (DUF502)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":6670,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":3,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":2},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"Predicted to be an integral membrane protein.","domain_architectures":38,"interpro_id":"IPR007462","known_evidence_count":null,"matches":9091,"name":"Protein of unknown function (DUF502)","partial_evidence_count":null,"pfam_id":"PF04367","proteins":9071,"proteomes":6263,"short_name":"DUF502","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04367","structures":0,"taxa":10061,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF04367.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":6670,"domain_architectures":38,"matches":9091,"proteins":9071,"proteomes":6263,"structures":0,"taxa":10061},"curation_status":"SEEDED","description":"Predicted to be an integral membrane protein.","id":"Pfam:PF04367","interpro_id":"InterPro:IPR007462","name":"Protein of unknown function (DUF502)","pfam_id":"PF04367","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF502","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04367"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF04367.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"e904d166fe9dcb4b1809f0d116f215a89c913bef868f27fa14f796fe462692f9"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Arabidopsis thaliana","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/stem-vascular-tissue-pattern-formation-go0010222.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0010222","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/stem-vascular-tissue-pattern-formation-go0010222.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf502-pf04367.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04367","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf502-pf04367.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:F4IUE7","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF04367"],"protein_name":"Protein CONTINUOUS VASCULAR RING 1","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"bd311081916e2056c45f14e414f97618848d822d8fefd3c8b0c74db83ff3893c","sequence_version":2,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MGDEKPVIVMANRERDRELLIPVADSGDKDDGSSSKPSSSSSASSSSHQSSHETLSLFIRGWASKKFMTGCVILLPIAITFYITWWFIHFVDGFFSPIYAQLGINVFGFGFLTSIAFIFLVGVFMSSWLGASVLNLGEWFIKRMPFVRHIYNASKQISTAISPDQNTQAFKEVAIIRHPRVGEYAFGFITSTVVLQNYPTEEELCCVYVPTNHLYIGDILLVNSNDVIRPNLSVREGIEIVVSGGMSMPQILSTVDKPLASIDRATSL","sequence_length":268,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"bd311081916e2056c45f14e414f97618848d822d8fefd3c8b0c74db83ff3893c","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/F4IUE7.json","taxon_id":"3702","uniprot_accession":"F4IUE7","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Arabidopsis thaliana","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/stem-vascular-tissue-pattern-formation-go0010222.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0010222","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/stem-vascular-tissue-pattern-formation-go0010222.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf502-pf04367.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04367","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf502-pf04367.yaml"}],"pfam_ids":["PF04367"],"protein_name":"Protein LIKE COV 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MANRERDRELLIPVADFGDKDDGSSSKPSSSSSASSSHQSGHETLSLFIRGWASKKFMTGCVILLPIAVTFYTTWWFIHFVDGFFSPIYALLGINIFGFGFLTSIAFIFLVGVFMSSWLGASVLNLGEWFIKRMPFVRHIYNASKQISTAISPDQNTQAFKEVAIIRHPRVGEYAFGFITSTVVLQNYPTEEELCCVYVPTNHLYIGDILLVNSNDVIRPNLSVREGIEIVVSGGMSMPQILSTLDKPLASIGNES","sequence_length":256,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"cbd7b9144abc1aa1923353bd5f6e5654e9e5e60b02ab5ce5e7061c053027b3a3","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8VY49.json","taxon_id":"3702","uniprot_accession":"Q8VY49","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Arabidopsis thaliana","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/stem-vascular-tissue-pattern-formation-go0010222.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0010222","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/stem-vascular-tissue-pattern-formation-go0010222.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf502-pf04367.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04367","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf502-pf04367.yaml"}],"pfam_ids":["PF04367"],"protein_name":"Protein LIKE COV 2","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAEGKEATTSSLSQGLTPHQDPDDAPKSPPNSPNSSTRKACYGVLQSWVSKKFMTGFVVLFPVAVTFLITWWFIQFVDGFFSPIYENLGVDIFGLGFITSVLFTFFVGIFASSWLGSTVFWLGEQFIRRMPFVKHIYSASKQISTAISPDQNTTAFKEVAIIRHPRIGEYAFGFITSSVTLQTDHGEEELCSVYVPTNHLYIGDVFLVSSEEIIRPNLSIREGIEIIVSVGMTMPQVISHVDRTTNRTPHQHSLRVPLNRL","sequence_length":261,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"39801ddf8865d50da54333eca49451bed9523c54372f1969246b1c923b52fad9","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9C8C1.json","taxon_id":"3702","uniprot_accession":"Q9C8C1","uniprot_release":"2026_03"}],"pfam_id":"PF04367","short_name":"DUF502","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}