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Unlike other aconitase family members that contain [4Fe-4S] clusters, AcnX enzymes utilise [2Fe-2S] or [3Fe-4S] clusters for catalysis [[cite:PUB00088769],[cite:PUB00161781]]. This domain forms part of the active site architecture but does not directly coordinate the iron-sulphur cluster.","domain_architectures":22,"interpro_id":"IPR060004","known_evidence_count":null,"matches":2040,"name":"Aconitase X first domain","partial_evidence_count":null,"pfam_id":"PF04412","proteins":2037,"proteomes":1846,"short_name":"AcnX","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04412","structures":5,"taxa":3243,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF04412.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1460,"domain_architectures":22,"matches":2040,"proteins":2037,"proteomes":1846,"structures":5,"taxa":3243},"curation_status":"SEEDED","description":"This entry represents the first domain of aconitase X (AcnX), which corresponds to domain 2 in the canonical four-domain architecture of the aconitase superfamily. 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This domain forms part of the active site architecture but does not directly coordinate the iron-sulphur cluster.","id":"Pfam:PF04412","interpro_id":"InterPro:IPR060004","name":"Aconitase X first 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