{"cross_mech":[],"family":{"alphafold_models":83,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This domain is found in phage proteins, such as A0A2H5BHG5 from Acinetobacter phage SH-Ab 15497, which are associated with PurZ, an enzyme that catalyses the synthesis of diaminopurine (Z), a DNA modification that gives phages an advantage for evading host restriction enzymes activity [[cite:PUB00097959]]. This domain has dATP and dGTP pyrophosphohydrolase activity; it catalyses the hydrolysis of dATP/dGTP to pyrophosphate and dAMP/dGMP, respectively, with little or no activities for NTPs and pyrimidine dNTPs. It is suggested that enzymes containing this domain supply dGMP as the substrate for PurZ, elevating dZTP level to promote Z incorporation [[cite:PUB00097959]].","domain_architectures":10,"interpro_id":"IPR007538","known_evidence_count":null,"matches":204,"name":"dATP/dGTP pyrophosphohydrolase","partial_evidence_count":null,"pfam_id":"PF04447","proteins":202,"proteomes":188,"short_name":"dATP-dGTP_PPHyd","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04447","structures":1,"taxa":506,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF04447.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":83,"domain_architectures":10,"matches":204,"proteins":202,"proteomes":188,"structures":1,"taxa":506},"curation_status":"SEEDED","description":"This domain is found in phage proteins, such as A0A2H5BHG5 from Acinetobacter phage SH-Ab 15497, which are associated with PurZ, an enzyme that catalyses the synthesis of diaminopurine (Z), a DNA modification that gives phages an advantage for evading host restriction enzymes activity [[cite:PUB00097959]]. This domain has dATP and dGTP pyrophosphohydrolase activity; it catalyses the hydrolysis of dATP/dGTP to pyrophosphate and dAMP/dGMP, respectively, with little or no activities for NTPs and pyrimidine dNTPs. It is suggested that enzymes containing this domain supply dGMP as the substrate for PurZ, elevating dZTP level to promote Z incorporation [[cite:PUB00097959]].","id":"Pfam:PF04447","interpro_id":"InterPro:IPR007538","name":"dATP/dGTP pyrophosphohydrolase","pfam_id":"PF04447","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"dATP-dGTP_PPHyd","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04447"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF04447.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"6fd4d23d6d006fa3438f817314622f4e7cef3d1914418ac1a979ff9938c667d2"}},"protein_examples":{"candidate_count":4,"discovery_scanned":true,"example_count":4,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Acinetobacter phage SH-Ab 15497","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/datp-dgtp-pphyd-pf04447.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04447","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/datp-dgtp-pphyd-pf04447.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/dgtp-diphyd-n-pf18909.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF18909","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/dgtp-diphyd-n-pf18909.yaml"}],"pfam_ids":["PF04447","PF18909"],"protein_name":"dATP/dGTP diphosphohydrolase","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSGNKFDQEKVDLHVLDPFFIEGTARVAQFGEQKYGRSNWMQGLTQTRIINAIKRHIAQIEKGEDIDEESGFHHAYHAAWGCQVLAYQHRNGQTHLDDRRWSESVRDADTKIGTCEGISGHTVPCMYEGPFGRLHPVDGEKDGLVMSFVQSEADEGTAQGDPIQQLQQMISEWADQVYPDRTVENALTKMMLHEIPELLHGKAMDPAEFADVAILLFDVAHLQGIDIAQAMREKMEINQARDWKIDPATGLMSHVKPKGMMETIRDAVQGIGDAARIMAAPSRLLNGNNMELAEYTAETLPKPPEKPWEITIPNWALKTEEGTHIKLRAGSGVFGRVKYQSQCILMHKNMRKRSHLETYYCATIKDTVTEDEYNVPWSEIEPWTN","sequence_length":385,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"186781cc1f8d95f12c4b9cd1e668868fc6ffc73a21de62bf5b8e77efd6ded1d7","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/A0A2H5BHG5.json","taxon_id":"2060946","uniprot_accession":"A0A2H5BHG5","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Salmonella phage PMBT28","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/datp-dgtp-pphyd-pf04447.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04447","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/datp-dgtp-pphyd-pf04447.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/dgtp-diphyd-n-pf18909.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF18909","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/dgtp-diphyd-n-pf18909.yaml"}],"pfam_ids":["PF04447","PF18909"],"protein_name":"dATP/dGTP diphosphohydrolase","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTGIKFDQGKAPLSLIDPRFTEEVARVLAIGEQKYGRANWQGLKIERLLDAVKRHVLELEKSNDHDDETGLHHAAHAASGLMFIFWLLNNRPTSDDRRWSAAVPGVREQRGSVQPVPDSEEGLDMQPVPAPSPSRSKKRAYSTGTIADVQKLISGWADRTFPDRTIGEAILKLKKELAELDTASYLDAGEFADVAILLLDIAQLAGIDIATAVANKMAINERRVWQRLEDGTHQHVIDGGRTDGVDPIIRVAMLPTDPTGSHLCVVCGQRFGSEDDRASHYTTTHGDRKP","sequence_length":290,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"286dd2e3d4172e1c3db4f0da25d201c1134847a1bd540812b6fca2d3eef4d367","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/A0A2L0V161.json","taxon_id":"2081904","uniprot_accession":"A0A2L0V161","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Cyanophage S-2L","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/datp-dgtp-pphyd-pf04447.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04447","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/datp-dgtp-pphyd-pf04447.yaml"}],"pfam_ids":["PF04447"],"protein_name":"dATP/dGTP diphosphohydrolase","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MPATVAELQAEIAAWIHPLNPDRRPGGTIAKLLEEIGELIASDRAHDPLEVADVLILALDLATLLGVDVTEAIRAKLAINRARSWARADNGAMRHIPGSDTPSFP","sequence_length":105,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"73072a936fedfa54f3a0b79b8bd06797bd8f31caf23713146588c188eedb66e6","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/A0A7U3TBV3.json","taxon_id":"260586","uniprot_accession":"A0A7U3TBV3","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Salmonella phage P22","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf551-pf04448.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF04448","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf551-pf04448.yaml"}],"pfam_ids":["PF04447","PF04448"],"protein_name":"Eaa protein","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTTITKERIELFVKSPLENGLTRGEQMELARIALASLDAETVRYLNKFSGTCVTLEQQPNAADDVAVYIPLYAAPPVPERERIRREHAEWSDKTFGDVGPVGPLKHLSKEALEAAADPSDPLEWADMQFLLWDAQRRMGISDEFITRAMIEKLEINKTRQWPEPKDGEPRLHIKEQPESVVPEECPAELPYAQVKAVADLYALCWQSGEVVTYTPDPEKATIWINNYSGTCVQEYVKLERLQEALAGNSPVIPGGWISCSERMPDNDESKPIAIFTGKCLGQGMFVATYDDDGFFDYWEGMEIIGVSHWMQLPDPPL","sequence_length":317,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"b1f4581a360a2951505fdd03b899941dae51abfcc3da5d33bfbc5c443f226cff","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q03544.json","taxon_id":"10754","uniprot_accession":"Q03544","uniprot_release":"2026_03"}],"pfam_id":"PF04447","short_name":"dATP-dGTP_PPHyd","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}