{"cross_mech":[],"family":{"alphafold_models":685,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"(5-formylfuran-3-yl)methyl phosphate synthase, also known as 4-HFC-P synthase, is involved in the production of methanofuran [[cite:PUB00085055],[cite:PUB00077121]]. This family has a classical TIM-barrel structure whose biological unit is a homohexamer [[cite:PUB00085055]].","domain_architectures":7,"interpro_id":"IPR007565","known_evidence_count":null,"matches":1023,"name":"4-HFC-P synthase","partial_evidence_count":null,"pfam_id":"PF04476","proteins":1020,"proteomes":990,"short_name":"4HFCP_synth","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04476","structures":2,"taxa":1530,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF04476.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":685,"domain_architectures":7,"matches":1023,"proteins":1020,"proteomes":990,"structures":2,"taxa":1530},"curation_status":"SEEDED","description":"(5-formylfuran-3-yl)methyl phosphate synthase, also known as 4-HFC-P synthase, is involved in the production of methanofuran [[cite:PUB00085055],[cite:PUB00077121]]. This family has a classical TIM-barrel structure whose biological unit is a homohexamer [[cite:PUB00085055]].","id":"Pfam:PF04476","interpro_id":"InterPro:IPR007565","name":"4-HFC-P synthase","pfam_id":"PF04476","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"4HFCP_synth","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04476"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF04476.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"44013b566dfce07ff0b979c8119672d1284785704817737cdef41516f8306311"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/4hfcp-synth-pf04476.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04476","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/4hfcp-synth-pf04476.yaml"}],"pfam_ids":["PF04476"],"protein_name":"(5-formylfuran-3-yl)methyl phosphate synthase","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MILLVSPKDVAEAYEAINGGADIIDVKNPPEGSLGANFPWVIKEIRSATPNGMLVSAAIGDVHYKPGTVTLAALGATISGADYIKIGLYGTRSYQEAVDVMKNVSNAVKSEDPKKIVVAAGYADAYRVGAVDPLIIPKIARDSGCDVAMLDTAVKDGKTLFDHLSIDLLKEFVEETHKYGMKCALAGSIKKEEIPMLKEIGCDIVGIRGAACTKGDRNEGKIQKDLVKEIVKICKE","sequence_length":236,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"8283bcf5bd15bfe188254cfd0e79298262b5635c0b8804d0cd4de3b4c9f388df","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/A6USK6.json","taxon_id":"406327","uniprot_accession":"A6USK6","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/carbon-carbon-lyase-activity-go0016830.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0016830","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/carbon-carbon-lyase-activity-go0016830.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/methanofuran-biosynthetic-process-go2001120.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:2001120","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/methanofuran-biosynthetic-process-go2001120.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/protein_family/ncbifam/5-formylfuran-3-yl-methyl-phosphate-synthase-nf002573.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:NF002573","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/protein_family/ncbifam/5-formylfuran-3-yl-methyl-phosphate-synthase-nf002573.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/protein_family/ncbifam/5-formylfuran-3-yl-methyl-phosphate-synthase-nf002575.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:NF002575","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/protein_family/ncbifam/5-formylfuran-3-yl-methyl-phosphate-synthase-nf002575.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/class-i-aldolases-class-i-aldolases-the-class-i-aldolases-use-an-activ-cd00945.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd00945","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/class-i-aldolases-class-i-aldolases-the-class-i-aldolases-use-an-activ-cd00945.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/4hfcp-synth-pf04476.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04476","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/4hfcp-synth-pf04476.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q58499","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF04476"],"protein_name":"(5-formylfuran-3-yl)methyl phosphate synthase","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"e45617d792114b99945c60929eeafed739c337dc950e65263b7a7933aeb17b5c","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MILLVSPIDVEEAKEAIAGGADIIDVKNPKEGSLGANFPWMIKAIREVTPKDLLVSATVGDVPYKPGTISLAAVGAAISGADYIKVGLYGVKNYYQAVELMKNVVRAVKDIDENKIVVAAGYADAYRVGAVEPLIVPKIARDAGCDVAMLDTAIKDGKTLFDFQSKEILAEFVDEAHSYGLKCALAGSIKKEHIPILKEIGTDIVGVRGAACKGGDRNNGRIDRELVKELKELCK","sequence_length":235,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"e45617d792114b99945c60929eeafed739c337dc950e65263b7a7933aeb17b5c","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q58499.json","taxon_id":"243232","uniprot_accession":"Q58499","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Methylorubrum extorquens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/4hfcp-synth-pf04476.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04476","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/4hfcp-synth-pf04476.yaml"}],"pfam_ids":["PF04476"],"protein_name":"Putative (5-formylfuran-3-yl)methyl phosphate synthase","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSDIVSISSARPRLLVSVRGPDEALTALRAGADLIDAKDPERGALGALPPETVRAIVAGVGGRAVTSAVAGDGTGREIAAAIATIAATGVDFIKIAVGGADDAALAEAAAQAPGRVIGVLFAEDDVAEDGPARLAAAGFVGAMIDTRGKSGTTLTSLMAAPQLAAFVAGCRTHGLMSGLAGSLGLGDIPVLARLDPDYLGFRGGLCRASDRRQALDGARVAQAVEAMRAGPRADAA","sequence_length":236,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"63bb993f9d68d14ad107900c0771ee6019ade5d5b345f6609c9eb870522ccb5f","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8GEK8.json","taxon_id":"408","uniprot_accession":"Q8GEK8","uniprot_release":"2026_03"}],"pfam_id":"PF04476","short_name":"4HFCP_synth","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
