{"cross_mech":[],"family":{"alphafold_models":6555,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This is a family of bactofilins, a functionally diverse class of cytoskeletal, polymer-forming, proteins that is widely conserved among bacteria. In the example species C. crescentus, two bactofilins assemble into a membrane-associated laminar structure that shows cell-cycle-dependent polar localisation and acts as a platform for the recruitment of a cell wall biosynthetic enzyme involved in polar morphogenesis. Bactofilins display distinct subcellular distributions and dynamics in different bacterial species, suggesting that they are versatile structural elements that have adopted a range of different cellular functions.","domain_architectures":35,"interpro_id":"IPR007607","known_evidence_count":null,"matches":9649,"name":"Polymer-forming cytoskeletal","partial_evidence_count":null,"pfam_id":"PF04519","proteins":9607,"proteomes":6945,"short_name":"Bactofilin","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04519","structures":3,"taxa":10792,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF04519.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":6555,"domain_architectures":35,"matches":9649,"proteins":9607,"proteomes":6945,"structures":3,"taxa":10792},"curation_status":"SEEDED","description":"This is a family of bactofilins, a functionally diverse class of cytoskeletal, polymer-forming, proteins that is widely conserved among bacteria. In the example species C. crescentus, two bactofilins assemble into a membrane-associated laminar structure that shows cell-cycle-dependent polar localisation and acts as a platform for the recruitment of a cell wall biosynthetic enzyme involved in polar morphogenesis. Bactofilins display distinct subcellular distributions and dynamics in different bacterial species, suggesting that they are versatile structural elements that have adopted a range of different cellular functions.","id":"Pfam:PF04519","interpro_id":"InterPro:IPR007607","name":"Polymer-forming cytoskeletal","pfam_id":"PF04519","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Bactofilin","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04519"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF04519.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"2f0730be624f0a795643fbc86526e15b9810319053976b8de7416fa03b1b940f"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Myxococcus xanthus (strain DK1622)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/repeat/pfam/bactofilin-pf04519.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04519","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/repeat/pfam/bactofilin-pf04519.yaml"}],"pfam_ids":["PF04519"],"protein_name":"Bactofilin BacN","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MATGETGIIGKGIVIKGNLTGGGDLVIEGRVEGQIALKNHLTIESTGKVQADIRAEELTINGEASGNIDASSRVAINASAKVAGDIKAPRVVIEDGAVFNGSIEMDVRLPDDI","sequence_length":113,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"72346e1846f90af2a53bc9b7d22509dc715d26bf0e8262ce8e3479aa90733c56","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q1D3H0.json","taxon_id":"246197","uniprot_accession":"Q1D3H0","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Myxococcus xanthus (strain DK1622)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/repeat/pfam/bactofilin-pf04519.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04519","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/repeat/pfam/bactofilin-pf04519.yaml"}],"pfam_ids":["PF04519"],"protein_name":"Bactofilin BacO","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSFTPRTARHTPFERRTTLMANTVIGSSIVIDGEISGDEDLVIQGTVKGKISLKESLYVEGSGVVEADIETQNVEIAGRVTGNIVASDKVELKTDCRVVGDIKAPRILIADGASFKGNVDMDMKER","sequence_length":126,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"5bccaa499c022cb4f92c16cf979a081479be52a877693cd6e2481c47592b2245","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q1D3H1.json","taxon_id":"246197","uniprot_accession":"Q1D3H1","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Myxococcus xanthus (strain DK1622)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/repeat/pfam/bactofilin-pf04519.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF04519","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/repeat/pfam/bactofilin-pf04519.yaml"}],"pfam_ids":["PF04519"],"protein_name":"Bactofilin BacP","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MATAKELSASSNVDNTVVGPSILISGRLTGDEDLTVRGRVEGELTLSRTLIVEPSGVVKANVAVKNAIVSGVVVGNINATESVELTREGRMVGDIRAPRVIIVDGASFRGRVDMGDVEPGRLPAERPAVVRPTAVTRPTATPARPTIPAARPMPPPPPSRPTPPPPPARPSAPPAVTRPSAPITRPGLGGLGSKPLPPPPPTRVERAEPQAGQAGSAEPPTPVLVGAGAKKKVVVKKKTR","sequence_length":240,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"504facdc6242cd85059de3036aaf73546d5fd7dea637213f33a8172f4d5d6606","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q1D3H2.json","taxon_id":"246197","uniprot_accession":"Q1D3H2","uniprot_release":"2026_03"}],"pfam_id":"PF04519","short_name":"Bactofilin","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}