{"cross_mech":[],"family":{"alphafold_models":4438,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This domain is characteristic of cilia- and flagella-associated protein 20 (CFA20). CFA20 is a cilium- and flagellum-specific protein that plays a role in axonemal structure organisation and motility [[cite:PUB00072946],[cite:PUB00072975]]. In Chlamydomonas reinhardtii, it stabilises outer doublet microtubules (DMTs) of the axoneme and may work as a scaffold for intratubular proteins, such as tektin and PACRG, to produce the beak structures in DMT1 [[cite:PUB00072975],[cite:PUB00072976]]. Other proteins contain a domain with homology to CFA20. WDR90/POC16 contains such a domain in its N terminus, followed by a large C-terminal domain with multiple WD40 repeats [[cite:PUB00072975]]. This domain is also present in the N terminus of uncharacterised protein C3orf67.","domain_architectures":223,"interpro_id":"IPR007714","known_evidence_count":null,"matches":6394,"name":"CFA20 domain","partial_evidence_count":null,"pfam_id":"PF05018","proteins":5992,"proteomes":2195,"short_name":"CFA20_dom","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05018","structures":28,"taxa":6576,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF05018.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":4438,"domain_architectures":223,"matches":6394,"proteins":5992,"proteomes":2195,"structures":28,"taxa":6576},"curation_status":"SEEDED","description":"This domain is characteristic of cilia- and flagella-associated protein 20 (CFA20). CFA20 is a cilium- and flagellum-specific protein that plays a role in axonemal structure organisation and motility [[cite:PUB00072946],[cite:PUB00072975]]. In Chlamydomonas reinhardtii, it stabilises outer doublet microtubules (DMTs) of the axoneme and may work as a scaffold for intratubular proteins, such as tektin and PACRG, to produce the beak structures in DMT1 [[cite:PUB00072975],[cite:PUB00072976]]. Other proteins contain a domain with homology to CFA20. WDR90/POC16 contains such a domain in its N terminus, followed by a large C-terminal domain with multiple WD40 repeats [[cite:PUB00072975]]. This domain is also present in the N terminus of uncharacterised protein C3orf67.","id":"Pfam:PF05018","interpro_id":"InterPro:IPR007714","name":"CFA20 domain","pfam_id":"PF05018","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"CFA20_dom","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05018"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF05018.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"cdb7208069ab351bb81e9c69c914c482cf3c54a3b9bf34b74dff7fdfcfef250f"}},"protein_examples":{"candidate_count":11,"discovery_scanned":true,"example_count":11,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Xenopus tropicalis","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/repeat/pfam/wdr90-beta-prop-4th-pf23342.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF23342","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/repeat/pfam/wdr90-beta-prop-4th-pf23342.yaml"}],"pfam_ids":["PF00400","PF05018","PF23342","PF23393","PF23409"],"protein_name":"WD repeat-containing protein 90","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAGVWQHPFVNVFKHLRLEEWKKSSKEGDVTSVMDKTLKCTVYRIRGSIPAGNYIQLPKTSSQSLGLTGRYLYILFKPLPGKHFVVHIDVSAEDGQTVRISFSNLFKEFKSTATWLQFPFVCGAIKGSVYDSTAQGARQGMVGPAPSGSRWTCLLLDVQYILSLYLSRRYSHLRSAKLCSNLLVRNLMTSDLLFNPEVNFMEARHAKTLPDGISPMPREMSFPVPKGEKWHDLYDFIMFPSDSSKLPYDSIQKGQSMVTAPGAPMSRSPARERPRSVTISKPVQDRVSLIQQITTPRPMPHRSLLRVESVPERPVSVSARAEEARDLEDRSRGVEQDGGVHVYAHKTNKLSIHRHKSDSEQVICTKVDRPETLSVPPECKKLLPDPIFNLRRIIGFGGCTECFALWTHTGCSVVYPCHAIIVVLEVKTGEQRFLLGHTDKVSALAFNGSCTLLASAQTGSLSMVRLWHFQKGSCLAMFKTHVHSVSYLSFSHSGTVLCGVGKDGHGKTMVVVWNTSQASRSGEVAVLAKAHTDIDIQTMKIAFFDDTRMVSCGKDNVRLWRVRGGTLRSCPVNLGEYHMLEFSDLAFEAGHRPEKEAEDRTLYVSSRSGHILEIDYKNVVLRNVRRVQPGQQQHSERRDKQTFSSGPGIAINSLSVSATFCATGTEDGYLRLWPLDFSGVFLEAEHEGPVSCVAISPEGLRVLSCTSSGELGVLDVPSRGYNTLMRSHTDTLLSFSCHPTHPQLVTVSSDNTIRIWDTGTLQQLYDFTAEEETPCAVTFHPVRQAFACGFSSGTIRFFDITATALQAEHKQHRGAITGLLFSPDGSLMYSCCSLGSVALYSIGHKEQHVLRVLGNVVCKDSERGPMALSLSSDGRLLAFVGPTEYTVTVMDARSLDELLRVDVSILDLDSTTLDCALGLAFSPLKPHHLLVSTSGNKILWLDPKTGRLTREVTQVHKQCCSSLAVSMDTRYMLTAGDRLLKVWDQRQPGTVRPQVFIGHSEAVQQVDFSPDQQSVISAGDAVFIWDFLAAPDPEFTKTDCVPALPFALHSSAALDPSSEHRRDSTFISSGMPRGTAPRPCISSPPRLDISPVQGMDHPDLFSESDDGQEEEGNRDEQERTLVPDTRDNLVESDEQSSVVIIECQPNRAKLLTGSKSNSSSLREGMVKSTHEPPRPDSYTHFHTRFKASCLAKGMCHPPEGQEMLTLRALIGYNGNGRANMAWNPDTGFFSYTCGCVIVVEDLHSGSQRHWLGHPEEISTLALTNDALVLASASGSGDGSSLCQIRIWDTQDGSCMKILTHHRTEVQAMSYSRDDRLFVSIGDYRDGNLALWSTKGYELLATSRLFQPVHAVTFNPAHFDDFASAGPGAVSFWRIETQGTDTQIKVYRVAVPEEVGTAAELTSITYNSTSLLYSGCSTGQVCVWDCQTHRCFLTWEADQGEIGILLCRGNRLLTGSNTRRIRLWCVAAVQELREKGSGASSTSVLMEHEMTLDGAIVSATFDDALEMGIVGTTAGTLWYINWVENTSIRLISGHRNKVMDLAVAHGESHCATCGEDGSLRIWSLQSCELLLQFQVLNQSCLCLAWSPQPKSGPSTEDQRIAAGYSDGTIRIFSVSKTEMEMKIHPHPCAVTSIAYSTSGDVLLTGGKDGQMAITSPRTGMTIRVLSDHKGSPITTIECTGRKLTGLPTDGELWLAASTDRRVSIWASDWSKDKCELLDWLSFPAPTSQKDLDVSVPTLAAFCPWQPGTVVYSGFGVEKEILFYSLIQKQVLLRIPLSHFATSLTLSPAASLIAVGSNERLLRLIDTSAGTKQDFAAYDDGVHLCRVSPSGNLLLTASYNQVLVWDIQNS","sequence_length":1848,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"d734888c87fe4f71a8c361516a20b6a6d2ad45e8576d1637c0f0cde457622687","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/A0JP70.json","taxon_id":"8364","uniprot_accession":"A0JP70","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Chlamydomonas 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taurus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/cfa20-dom-pf05018.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF05018","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/cfa20-dom-pf05018.yaml"}],"pfam_ids":["PF05018"],"protein_name":"Cilia- and flagella-associated protein 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musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/cfa20-domain-ipr007714.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR007714","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/cfa20-domain-ipr007714.yaml"}],"pfam_ids":["PF05018"],"protein_name":"Protein 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musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/repeat/pfam/beta-prop-wdr90-poc16-2nd-pf23393.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF23393","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/repeat/pfam/beta-prop-wdr90-poc16-2nd-pf23393.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/repeat/pfam/wdr90-beta-prop-4th-pf23342.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF23342","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/repeat/pfam/wdr90-beta-prop-4th-pf23342.yaml"}],"pfam_ids":["PF05018","PF23342","PF23393","PF23409"],"protein_name":"WD repeat-containing protein 90","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAGGSGARETRCRQGSRPGSPGSEVPAASVTGPRAEARPAGGGGGSRRAAPDRCSGGVPSAAWQHPFLNVFRHFRVDEWKRSSKEGDVAVVTDKVLKSAVYRIRGSVSASNYIQLPRTSTQSLGLTGRYLYVLFRPVPTKHFVIHLDVSTEDGQVIRVSFSNLFKEFKSSTTWLQFPFVFETKTPRRDLAGVALPRARWTCLQLDLRDILMFYLGRHYSHLKSIRLCASLLVRNLYTSDLCFDPAVTVTEARRAKLSVNPMPREMAFPVPKGESWHDNYIHVRFPSDCSKVPDEQDEKSCSPPEAVFLGRMSRHLPHPGVLGKPLLSSKSPVAQACSSALPCQVLSASSRLPEVSRTYRYREVSSVSASSIQSQRPSVRDEVPDAHTVSGERHVLADRSSGVPMALEDIGSCRLFLPDPVLRLKGVIGFGGHSTQWALWTKDGVAVVYPCHAVIIVLQIDTGQQRFFLGHTDKVSALALNGSDTLLASAQVQPPSMVRLWDFQTGSCLSLFRSPLHTICSLSFSGSGALLCGVGKDRHGRTVVVAWSTEQAGLGGEVVVLAKVHTDFDIRAFQVAFFDETRMASCGRGSVRLWRLRGGVLRSCAVDLGEYCSLELTDLAFAQALDGHCAPSAGTLFVCSHSGHILEIDHQRMSVQHVRRLLPARSPGAPLAEKQNFSVGSGIAISSLSVSTATCAVGSEDGYLRLWPLDFSSVLLEAEHDGPVSSVSFSPDGLRVLSTTTSGHLGFLDVPSREYTVLARSHMAPVLALSTEPNRGQMATVSLDHTVRIWDLATLQQLYDFSSSEDTPCAVAFHPTMPNFFCGFSSGAVRSFSLESSGVLVEHTRHRGAITSLVITLDGRFLFSSCSQGSLVQYSCADSQCCVLRVAANMVCQDGRPNPNILAVSGDSCRLAFVGPSKCMVTIVESASLDELLRVDVSTLNLASNHLDWAVAICFSPGNSGHLLVSTSSNKVVVLDAVSGHTLRELSSVRSRACCSLALSEDAHLLLAATDRTITVWDYPTQANPSCQVYIGHSEPVHAVAFTPDQLQVISVGDAIFLWDILATPERDGGDHEAPPGHEAGSSSGQLDDLASGASGLPRQQVPIPFQALPPPLSSHDRLLDGSTGTFSTSDEEGLCEENHVSEALLQGQAPTPHVLVDREASGAGDAPRETAGSSWTPAERPSPHSHMSEWSLRSGKAGLPTRPDSYKHFTPRYKTSPRVKSVYFPPIGRERLRLKAIVGYNGNGRANMVWRPDTGFFAYTCGRLVVVEDLHSGTQRHWLGHSQEISTLALNQDGQILASASCCGNTAARCQIRIWDVPKGLCRHLLSHHDTAVQALAFSPDDEFLVTLGDYADRNLALWSMATYELLSSTRLLEPVHGVAFNPWDANELICVGTNAITFWLLQHHGADTCFQVHREPIPEELGASELTSLCYGASPLLYCGSSSGQVCVWDTGTGHCFLAWEADDGEIGVLLCSGSRLISGSNTKRLRLWAVGVVPELRRKGSSARSSSVFMERELTLDGAVVSASFDSGMDMGVVGTTAGTIWYISWTEGTSTRLISGHRTKVNEVVFSPGESHCATCGEDGSVRVWSLASMELVIQFQVLNQSCLCLAWTPPSCELPEQQQVVAGYSDGTLRVFSISRTAMELKMHPHRTALTAIAFSTDGQTILSGDKDGLVAISHPCTGMTFRVLSDHRGAPISAIQSTSKEYGDLGVEGVELWLAASGDQRVSIWVSDWLRDRCELLEWLSFPAPAVSEAPGLLPPSLAAFCPWDKAILVCVGLGAHEEVIFYSLRQKQVIQKTPLPFFAMSLSLSPGSQLMVVGFAECMMRLLDCASGTAQDLEGHDDSVHLCRFTPSGRLLFTAAHNEILVWEVTDP","sequence_length":1874,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"5111798550f5c2eda973167c6d4a47a08d9647456af80158eed00c727a190484","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q6ZPG2.json","taxon_id":"10090","uniprot_accession":"Q6ZPG2","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo 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