{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF05071","protein_label":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2","reviewed":true,"short_name":"NDUFA12","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/ndufa12-pf05071.yaml","source_record_id":"Pfam:PF05071","source_record_label":"NADH ubiquinone oxidoreductase subunit NDUFA12","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q59J78","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF05071","protein_label":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12","reviewed":true,"short_name":"NDUFA12","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/ndufa12-pf05071.yaml","source_record_id":"Pfam:PF05071","source_record_label":"NADH ubiquinone oxidoreductase subunit NDUFA12","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q7TMF3","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF05071","protein_label":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2","reviewed":true,"short_name":"NDUFA12","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/ndufa12-pf05071.yaml","source_record_id":"Pfam:PF05071","source_record_label":"NADH ubiquinone oxidoreductase subunit NDUFA12","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q8N183","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF05071","protein_label":"Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12","reviewed":true,"short_name":"NDUFA12","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/ndufa12-pf05071.yaml","source_record_id":"Pfam:PF05071","source_record_label":"NADH ubiquinone oxidoreductase subunit NDUFA12","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9M9M9","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF05071","protein_label":"Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12","reviewed":true,"short_name":"NDUFA12","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/ndufa12-pf05071.yaml","source_record_id":"Pfam:PF05071","source_record_label":"NADH ubiquinone oxidoreductase subunit NDUFA12","source_section":"canonical_examples","taxon_id":"NCBITaxon:6239","taxon_label":"Caenorhabditis elegans","uniprot_accession":"Q9N2W7","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF05071","protein_label":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12","reviewed":true,"short_name":"NDUFA12","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/ndufa12-pf05071.yaml","source_record_id":"Pfam:PF05071","source_record_label":"NADH ubiquinone oxidoreductase subunit NDUFA12","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q9UI09","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF05071","protein_label":"","reviewed":null,"short_name":"NDUFA12","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/ndufa12-pf05071.yaml","source_record_id":"Pfam:PF05071","source_record_label":"NADH ubiquinone oxidoreductase subunit NDUFA12","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":7460,"candidate_reasons":["description_says_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":6,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":1},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family contains the 17.2 kD subunit of complex I (NDUFA12) and its homologues. The family also contains a second related eukaryotic protein of unknown function, e.g. [swissprot:Q9BV02].","domain_architectures":92,"interpro_id":"IPR007763","known_evidence_count":null,"matches":9228,"name":"NADH ubiquinone oxidoreductase subunit NDUFA12","partial_evidence_count":null,"pfam_id":"PF05071","proteins":9214,"proteomes":5704,"short_name":"NDUFA12","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05071","structures":291,"taxa":11992,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF05071.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":7460,"domain_architectures":92,"matches":9228,"proteins":9214,"proteomes":5704,"structures":291,"taxa":11992},"curation_status":"SEEDED","description":"This family contains the 17.2 kD subunit of complex I (NDUFA12) and its homologues. The family also contains a second related eukaryotic protein of unknown function, e.g. [swissprot:Q9BV02].","id":"Pfam:PF05071","interpro_id":"InterPro:IPR007763","name":"NADH ubiquinone oxidoreductase subunit NDUFA12","pfam_id":"PF05071","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"NDUFA12","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05071"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF05071.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"401ef50977d07c4c86b7a2796378e2417ef8ff8ad1068f08b5fe20ae102c2715"}},"protein_examples":{"candidate_count":6,"discovery_scanned":true,"example_count":6,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/ndufa12-pf05071.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF05071","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/ndufa12-pf05071.yaml"}],"pfam_ids":["PF05071"],"protein_name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSWWSGVWRSVWSALSREVREHVGTDHLGNKYYYVAEYKNWRGQTIREKRIVEAANRKEVDYEAGDIPTEWEAWIRRTRKTPPTMEEILKNEKYREEIKIKSQDFYEKDKLGKETSEELLPSPTATQVKGHASAPYFGREEPSVAPTSTGKTFQPGSWTPEDGKRQSQ","sequence_length":168,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"a54593b2a25e0cc5825e0b220a22d484b48902a189a01bae77dc696ab7a0c513","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q59J78.json","taxon_id":"10090","uniprot_accession":"Q59J78","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/ndufa12-pf05071.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF05071","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/ndufa12-pf05071.yaml"}],"pfam_ids":["PF05071"],"protein_name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MELVEVLKRGVQQVTGHGGLRGLLRVFFRANDIRIGTLVGEDKYGNKYYEDNKQFFGRHRWVIYTTEMNGKNTFWDVDGSMVPPEWHRWLHCMTDDPPTTNPPTARKFIWTNHKFNVSATPEQYVPYSTTRKKIHEWVPPSTPYK","sequence_length":145,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"ab093c1c832a8965f39fa60c8b47316c9f3650d3e4e6288e869f6106631e9b6e","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q7TMF3.json","taxon_id":"10090","uniprot_accession":"Q7TMF3","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/ndufa12-pf05071.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF05071","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/ndufa12-pf05071.yaml"}],"pfam_ids":["PF05071"],"protein_name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MGWSQDLFRALWRSLSREVKEHVGTDQFGNKYYYIPQYKNWRGQTIREKRIVEAANKKEVDYEAGDIPTEWEAWIRRTRKTPPTMEEILKNEKHREEIKIKSQDFYEKEKLLSKETSEELLPPPVQTQIKGHASAPYFGKEEPSVAPSSTGKTFQPGSWMPRDGKSHNQ","sequence_length":169,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"11c727dec3b99dd071e482ec7b9f24e6cd1a296bbad0a5497cee78de21388e70","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8N183.json","taxon_id":"9606","uniprot_accession":"Q8N183","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Arabidopsis thaliana","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/ndufa12-pf05071.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF05071","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/ndufa12-pf05071.yaml"}],"pfam_ids":["PF05071"],"protein_name":"Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MALTVAKSALEAIREKGLGGFMRMIREEGFMRCLPDGNLLQTKIHNIGATLVGVDKFGNKYYQKLGDTQYGRHRWVEYASKDRYNASQVPAEWHGWLHFITDHTGDELLSLKPKRYGLEHKENFSGEGDAYIYHSKGHTLNPGQKNWTRYQSWVPTKTQ","sequence_length":159,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"b6e48da2e97ee952735091c076e6841108fd474ab5be2cfb22d45655f47ec08a","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9M9M9.json","taxon_id":"3702","uniprot_accession":"Q9M9M9","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Caenorhabditis elegans","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/ndufa12-pf05071.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF05071","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/ndufa12-pf05071.yaml"}],"pfam_ids":["PF05071"],"protein_name":"Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSLKAWLGIDKIQKFGQMVKEIGGVKAVLKKRYLMDATRVGTLVGSDNFGNRYYENNAYFVPRNRWVEFPDKVWLDYDATQVPPEWHSWLHHITDDAPSVKPPPTQDWVLEHKENTSIYADKKYVPYSTTRTKIQGWQPGEKPQFD","sequence_length":146,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"97f7836f69925c72e0bc3c3521777f3d75cff2d9e7f92be01410e2b4d9af1c0a","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q9N2W7.json","taxon_id":"6239","uniprot_accession":"Q9N2W7","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/ndufa12-pf05071.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF05071","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/ndufa12-pf05071.yaml"}],"pfam_ids":["PF05071"],"protein_name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MELVQVLKRGLQQITGHGGLRGYLRVFFRTNDAKVGTLVGEDKYGNKYYEDNKQFFGRHRWVVYTTEMNGKNTFWDVDGSMVPPEWHRWLHSMTDDPPTTKPLTARKFIWTNHKFNVTGTPEQYVPYSTTRKKIQEWIPPSTPYK","sequence_length":145,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"28e083beca9d33c94f7e295839174332572b195698223ab23949c772cca7f79a","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9UI09.json","taxon_id":"9606","uniprot_accession":"Q9UI09","uniprot_release":"2026_03"}],"pfam_id":"PF05071","short_name":"NDUFA12","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}