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EccB, EccC, EccD, and EccE form a stable complex in the mycobacterial cell envelope [[cite:PUB00083131]].","domain_architectures":4,"interpro_id":"IPR007795","known_evidence_count":null,"matches":4744,"name":"Type VII secretion system ESX-1, transport TM domain B","partial_evidence_count":null,"pfam_id":"PF05108","proteins":4566,"proteomes":2423,"short_name":"T7SS_ESX1_EccB","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05108","structures":19,"taxa":2868,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF05108.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":2663,"domain_architectures":4,"matches":4744,"proteins":4566,"proteomes":2423,"structures":19,"taxa":2868},"curation_status":"SEEDED","description":"EccB is a family of largely Gram-positive bacterial transmembrane componenets of the type VII secretion system characterised in Mycobacterium tuberculosis, systems ESX1-5. Translocation of virulent peptides through the membranes is thought to be mediated via a complex that includes EccB, EccC, EccD, EccE, and MycP [[cite:PUB00083129],[cite:PUB00106938]]. EccB, EccC, EccD, and EccE form a stable complex in the mycobacterial cell envelope [[cite:PUB00083131]].","id":"Pfam:PF05108","interpro_id":"InterPro:IPR007795","name":"Type VII secretion system ESX-1, transport TM domain B","pfam_id":"PF05108","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"T7SS_ESX1_EccB","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05108"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF05108.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"8594a55974f8e4800265da76bdc214e30b7bf5b86a52b87405d69fc778a0e932"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)","origins":[{"cited_uniprot_accession":"A0QQ39","commit":"937ba6254eb987adcbd92e82b21b2ce8651dc5e3","link_basis":["uniprot_pfam_xref"],"mech":"CellStructureMech","path":"data/structures/secretion_system/esx_3_type_vii_secretion_system_membrane_complex.yaml","qualification_status":"NOT_ASSESSED","record_id":"cellstructuremech:esx_3_type_vii_secretion_system_membrane_complex","section":"uniprot_accession","url":"https://github.com/CultureBotAI/CellStructureMech/blob/937ba6254eb987adcbd92e82b21b2ce8651dc5e3/data/structures/secretion_system/esx_3_type_vii_secretion_system_membrane_complex.yaml"}],"pfam_ids":["PF05108"],"protein_name":"ESX-3 secretion system ATPase EccB3","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTGPVNPDDRRSFSSRTPVNENPDGVQYRRGFVTRHQVSGWRFVMRRIASGVALHDTRMLVDPLRTQSRAVLTGALILVTGLVGCFIFSLFRPGGVPGNNAILADRSTSALYVRVGEQLHPVLNLTSARLISGSPDNPTMVKTSEIDKFPRGNLLGIPGAPERMVQNAATDAEWTVCDAVGGANPGVTVIAGPLGADGERAAPLPPDHAVLVHSDAEPNPGDWLLWDGKRSPIDLADRAVTDALGLGGQALAPRPIAAGLFNAVPAAPALTAPVIPDAGAAPQFELSLPVPVGAVVVAYDADNTARYYAVLSDGLQPISPVLAAILRNTDSHGFAQPPRLGPDEVARTPMSRGLDTSAYPDNPVTLVEASAHPVTCAHWTKPSDAAESSLSVLSGAVLPLAEGLHTVDLVGAGAGGAANRVALTPGTGYFVQTVGAEPGSPTAGSMFWVSDTGVRYGIDTAEDDKVVAALGLSTSPLPVPWSVLSQFAAGPALSRGDALVAHDAVSTNPNSARMEASR","sequence_length":518,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"99734711a4171368f88f6dcce5c4b7bda358229a5870aacfb015d2ebe3c8ece1","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/A0QQ39.json","taxon_id":"246196","uniprot_accession":"A0QQ39","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)","origins":[{"cited_uniprot_accession":"P9WNQ9","commit":"937ba6254eb987adcbd92e82b21b2ce8651dc5e3","link_basis":["uniprot_pfam_xref"],"mech":"CellStructureMech","path":"data/structures/secretion_system/esx_5_type_vii_secretion_system_membrane_complex.yaml","qualification_status":"NOT_ASSESSED","record_id":"cellstructuremech:esx_5_type_vii_secretion_system_membrane_complex","section":"uniprot_accession","url":"https://github.com/CultureBotAI/CellStructureMech/blob/937ba6254eb987adcbd92e82b21b2ce8651dc5e3/data/structures/secretion_system/esx_5_type_vii_secretion_system_membrane_complex.yaml"}],"pfam_ids":["PF05108"],"protein_name":"ESX-5 secretion system ATPase EccB5","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAEESRGQRGSGYGLGLSTRTQVTGYQFLARRTAMALTRWRVRMEIEPGRRQTLAVVASVSAALVICLGALLWSFISPSGQLNESPIIADRDSGALYVRVGDRLYPALNLASARLITGRPDNPHLVRSSQIATMPRGPLVGIPGAPSSFSPKSPPASSWLVCDTVATSSSIGSLQGVTVTVIDGTPDLTGHRQILSGSDAVVLRYGGDAWVIREGRRSRIEPTNRAVLLPLGLTPEQVSQARPMSRALFDALPVGPELLVPEVPNAGGPATFPGAPGPIGTVIVTPQISGPQQYSLVLGDGVQTLPPLVAQILQNAGSAGNTKPLTVEPSTLAKMPVVNRLDLSAYPDNPLEVVDIREHPSTCWWWERTAGENRARVRVVSGPTIPVAATEMNKVVSLVKADTSGRQADQVYFGPDHANFVAVTGNNPGAQTSESLWWVTDAGARFGVEDSKEARDALGLTLTPSLAPWVALRLLPQGPTLSRADALVEHDTLPMDMTPAELVVPK","sequence_length":506,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"a4a975d6b4a1304a7361385f0589d0e3a9ae6288e34f59380b7107673bec70c8","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P9WNQ9.json","taxon_id":"83332","uniprot_accession":"P9WNQ9","uniprot_release":"2026_03"}],"pfam_id":"PF05108","short_name":"T7SS_ESX1_EccB","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}