{"cross_mech":[],"family":{"alphafold_models":3641,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family of short proteins contains a putative zinc binding domain with four conserved cysteines. [swissprot:P36053] has been identified as a transcription elongation factor in Saccharomyces cerevisiae [[cite:PUB00033659]].","domain_architectures":37,"interpro_id":"IPR007808","known_evidence_count":null,"matches":4263,"name":"Transcription elongation factor Elf1 like","partial_evidence_count":null,"pfam_id":"PF05129","proteins":4255,"proteomes":2915,"short_name":"Zn_ribbon_Elf1","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05129","structures":37,"taxa":7886,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF05129.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":3641,"domain_architectures":37,"matches":4263,"proteins":4255,"proteomes":2915,"structures":37,"taxa":7886},"curation_status":"SEEDED","description":"This family of short proteins contains a putative zinc binding domain with four conserved cysteines. [swissprot:P36053] has been identified as a transcription elongation factor in Saccharomyces cerevisiae [[cite:PUB00033659]].","id":"Pfam:PF05129","interpro_id":"InterPro:IPR007808","name":"Transcription elongation factor Elf1 like","pfam_id":"PF05129","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Zn_ribbon_Elf1","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05129"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF05129.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"6af382d92b224244a6aaa7603eabe387d3e6502e0267923669bb7f5b7b4f6fd1"}},"protein_examples":{"candidate_count":6,"discovery_scanned":true,"example_count":6,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/zn-ribbon-elf1-pf05129.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF05129","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/zn-ribbon-elf1-pf05129.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/transcription-elongation-factor-1-superfamily-ipr038567.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR038567","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/transcription-elongation-factor-1-superfamily-ipr038567.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/2-20-25-190-2-20-25-190.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:2.20.25.190","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/2-20-25-190-2-20-25-190.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:P36053","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF05129"],"protein_name":"Transcription elongation factor 1","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"16a6fe970745bf4d3c92f8d4ada3438b4dc4ed04ad0c9ad903075f301eabee82","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MGKRKKSTRKPTKRLVQKLDTKFNCLFCNHEKSVSCTLDKKNSIGTLSCKICGQSFQTRINSLSQPVDVYSDWFDAVEEVNSGRGSDTDDGDEGSDSDYESDSEQDAKTQNDGEIDSDEEEVDSDEERIGQVKRGRGALVDSDDE","sequence_length":145,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"16a6fe970745bf4d3c92f8d4ada3438b4dc4ed04ad0c9ad903075f301eabee82","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P36053.json","taxon_id":"559292","uniprot_accession":"P36053","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/zn-ribbon-elf1-pf05129.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF05129","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/zn-ribbon-elf1-pf05129.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/transcription-elongation-factor-1-superfamily-ipr038567.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR038567","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/transcription-elongation-factor-1-superfamily-ipr038567.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/2-20-25-190-2-20-25-190.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:2.20.25.190","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/2-20-25-190-2-20-25-190.yaml"}],"pfam_ids":["PF05129"],"protein_name":"Transcription elongation factor 1 homolog","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MGRRKSKRKPPPKKKMTGTLETQFTCPFCNHEKSCDVKMDRARNTGVISCTVCLEEFQTPITYLSEPVDVYSDWIDACEAANQ","sequence_length":83,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"908b03979d398dce54f131aa4486cd105962b4c62418b44afc324ee2baa3228d","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P60002.json","taxon_id":"9606","uniprot_accession":"P60002","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/zn-ribbon-elf1-pf05129.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF05129","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/zn-ribbon-elf1-pf05129.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/transcription-elongation-factor-1-superfamily-ipr038567.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR038567","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/transcription-elongation-factor-1-superfamily-ipr038567.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/2-20-25-190-2-20-25-190.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:2.20.25.190","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/2-20-25-190-2-20-25-190.yaml"}],"pfam_ids":["PF05129"],"protein_name":"Transcription elongation factor 1 homolog","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MGRRKSKRKPPPKKKMTGTLETQFTCPFCNHEKSCDVKMDRARNTGVISCTVCLEEFQTPITYLSEPVDVYSDWIDACEAANQ","sequence_length":83,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"908b03979d398dce54f131aa4486cd105962b4c62418b44afc324ee2baa3228d","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P60003.json","taxon_id":"10090","uniprot_accession":"P60003","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Arabidopsis thaliana","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/zn-ribbon-elf1-pf05129.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF05129","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/zn-ribbon-elf1-pf05129.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/transcription-elongation-factor-1-superfamily-ipr038567.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR038567","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/transcription-elongation-factor-1-superfamily-ipr038567.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/2-20-25-190-2-20-25-190.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:2.20.25.190","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/2-20-25-190-2-20-25-190.yaml"}],"pfam_ids":["PF05129"],"protein_name":"Transcription elongation factor 1 homolog","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MGKRKSRAKPAPTKRMDKLDTIFSCPFCNHGSSVECIIDMKHLIGKAACRICEESFSTTITALTEAIDIYSEWIDECERVNTAEDDVVQEEEEEVEEEEEEEEEEDDEDDHVSVKRKYNF","sequence_length":120,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"6d519a2181311c816321bf0b9bf768480860237d775f75833323e7c6146c7ff5","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8LEF3.json","taxon_id":"3702","uniprot_accession":"Q8LEF3","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Drosophila melanogaster","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/zn-ribbon-elf1-pf05129.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF05129","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/zn-ribbon-elf1-pf05129.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/transcription-elongation-factor-1-superfamily-ipr038567.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR038567","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/transcription-elongation-factor-1-superfamily-ipr038567.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/2-20-25-190-2-20-25-190.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:2.20.25.190","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/2-20-25-190-2-20-25-190.yaml"}],"pfam_ids":["PF05129"],"protein_name":"Transcription elongation factor 1 homolog","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MGRRKSKRKPPPKRKNIEPLDQQFNCPFCNHEKSCEVKMDKSRNTAKITCRVCLEDFQTGINFLSEPIDVYNDWVDACETAN","sequence_length":82,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"2c56155b9588371f75b5323e37379ded1e8b246c7e62fea606679bbbc48854f6","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8MQI6.json","taxon_id":"7227","uniprot_accession":"Q8MQI6","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Caenorhabditis elegans","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/zn-ribbon-elf1-pf05129.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF05129","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/zn-ribbon-elf1-pf05129.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/transcription-elongation-factor-1-superfamily-ipr038567.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR038567","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/transcription-elongation-factor-1-superfamily-ipr038567.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/2-20-25-190-2-20-25-190.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:2.20.25.190","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/2-20-25-190-2-20-25-190.yaml"}],"pfam_ids":["PF05129"],"protein_name":"Transcription elongation factor 1 homolog","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MGKRKSKRKAPTKAKAVMPLDTQFNCPFCNHERVCEVKMDREKNVGYISCRVCSEDFQTNINYLSEPIDVYSDWVDACEQANNA","sequence_length":84,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"6b7d29fdcaed7fa29db7669f1702cd1d0d26b94dbee005d07f276f9c19ecf6ba","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9XVZ8.json","taxon_id":"6239","uniprot_accession":"Q9XVZ8","uniprot_release":"2026_03"}],"pfam_id":"PF05129","short_name":"Zn_ribbon_Elf1","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}