{"cross_mech":[],"family":{"alphafold_models":3301,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family consists of several uncharacterised eukaryotic proteins which are related to methyltransferases [pfam:PF01209].","domain_architectures":104,"interpro_id":"IPR007823","known_evidence_count":null,"matches":4194,"name":"Hypothetical methyltransferase","partial_evidence_count":null,"pfam_id":"PF05148","proteins":3896,"proteomes":3235,"short_name":"Methyltransf_8","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05148","structures":1,"taxa":8620,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF05148.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":3301,"domain_architectures":104,"matches":4194,"proteins":3896,"proteomes":3235,"structures":1,"taxa":8620},"curation_status":"SEEDED","description":"This family consists of several uncharacterised eukaryotic proteins which are related to methyltransferases [pfam:PF01209].","id":"Pfam:PF05148","interpro_id":"InterPro:IPR007823","name":"Hypothetical methyltransferase","pfam_id":"PF05148","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Methyltransf_8","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05148"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF05148.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"4fba5df2f8018da30f1e23257810d0a3cb1ae5a8d16ba1b6571b8b79becd8e44"}},"protein_examples":{"candidate_count":6,"discovery_scanned":true,"example_count":6,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/regulation-of-g1-to-g0-transition-go1903450.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:1903450","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/regulation-of-g1-to-g0-transition-go1903450.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/regulation-of-transcription-by-glucose-go0046015.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0046015","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/regulation-of-transcription-by-glucose-go0046015.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/conservation/interpro/ubie-coq5-methyltransferase-conserved-site-ipr023576.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR023576","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/conservation/interpro/ubie-coq5-methyltransferase-conserved-site-ipr023576.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/methyltransf-8-pf05148.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF05148","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/methyltransf-8-pf05148.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/ribosomal-rna-processing-protein-8-n-terminal-domain-ipr042036.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR042036","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/ribosomal-rna-processing-protein-8-n-terminal-domain-ipr042036.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/ribosomal-rna-processing-protein-8-n-terminal-domain-1-10-10-2150.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:1.10.10.2150","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/ribosomal-rna-processing-protein-8-n-terminal-domain-1-10-10-2150.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:O43159","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF05148"],"protein_name":"Ribosomal RNA-processing protein 8","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"90c46d9104ea602a4d9235dba48f1be9eab7d789359c710a0933eab50dbf84b0","sequence_version":2,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MFEEPEWAEAAPVAAGLGPVISRPPPAASSQNKGSKRRQLLATLRALEAASLSQHPPSLCISDSEEEEEERKKKCPKKASFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKKKCHKQALVGSDSAEDEKRKRKCQKHAPINSAQHLDNVDQTGPKAWKGSTTNDPPKQSPGSTSPKPPHTLSRKQWRNRQKNKRRCKNKFQPPQVPDQAPAEAPTEKTEVSPVPRTDSHEARAGALRARMAQRLDGARFRYLNEQLYSGPSSAAQRLFQEDPEAFLLYHRGFQSQVKKWPLQPVDRIARDLRQRPASLVVADFGCGDCRLASSIRNPVHCFDLASLDPRVTVCDMAQVPLEDESVDVAVFCLSLMGTNIRDFLEEANRVLKPGGLLKVAEVSSRFEDVRTFLRAVTKLGFKIVSKDLTNSHFFLFDFQKTGPPLVGPKAQLSGLQLQPCLYKRR","sequence_length":456,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"90c46d9104ea602a4d9235dba48f1be9eab7d789359c710a0933eab50dbf84b0","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/O43159.json","taxon_id":"9606","uniprot_accession":"O43159","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Caenorhabditis elegans","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/methyltransf-8-pf05148.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF05148","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/methyltransf-8-pf05148.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/ribosomal-rna-processing-protein-8-n-terminal-domain-ipr042036.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR042036","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/ribosomal-rna-processing-protein-8-n-terminal-domain-ipr042036.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/ribosomal-rna-processing-protein-8-n-terminal-domain-1-10-10-2150.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:1.10.10.2150","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/ribosomal-rna-processing-protein-8-n-terminal-domain-1-10-10-2150.yaml"}],"pfam_ids":["PF05148"],"protein_name":"Ribosomal RNA-processing protein 8","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MGKKRKITDEKDAQHVPAEKREKVENWLKKSTEKPTSSQSDAEKKKKRPWRNKVRKLAAKKAAADKKSENPEEPPLILEPKSSSDENTKKKRKRGPKKKKFKPEVAGKAAETENDDVAAAPEEADPIAEAKKRLDAGRFRFLNEKLYTCTGSEAFDFFKEDPTAFDLYHKGFADQVKKWPNHPLREIIRWLQSKPDQQSVFDLGCGEAKIAEAVGEKHKIRSFDLVAVNDRVESCDMSKLPAEDSSADIVIYCLSLMGTNLYDFIREARRVLKIGGILKIAEVTSRFVSIKQFCEAITKMGFEQSHRRELTDYFMMMEFKKVEKVEQKRPYGLKLKPCLYKKR","sequence_length":343,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"9902f1763e59b024947790ea81df326b78c285e3ab69a60c1e7270e72622294d","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/O44410.json","taxon_id":"6239","uniprot_accession":"O44410","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/rrna-adenine-methyltransferase-activity-go0016433.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0016433","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/rrna-adenine-methyltransferase-activity-go0016433.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/rrna-adenine-n1-methyltransferase-activity-go0106142.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0106142","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/rrna-adenine-n1-methyltransferase-activity-go0106142.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/methyltransf-8-pf05148.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF05148","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/methyltransf-8-pf05148.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/ribosomal-rna-processing-protein-8-n-terminal-domain-ipr042036.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR042036","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/ribosomal-rna-processing-protein-8-n-terminal-domain-ipr042036.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/ribosomal-rna-processing-protein-8-n-terminal-domain-1-10-10-2150.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:1.10.10.2150","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/ribosomal-rna-processing-protein-8-n-terminal-domain-1-10-10-2150.yaml"}],"pfam_ids":["PF05148"],"protein_name":"25S rRNA (adenine(645)-N(1))-methyltransferase","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MALFNVEGWSIKTKTVAFDNKTNKSSKDKKKNNRKNGKLTREQKLKEETEAELKEQVEDIPSEGSVAKDIPKKNQEKSDQNETSKKRKHDEEAPLMQVKENIEKPTKKQLTPLQQKMMAKLTGSRFRWINEQLYTISSDEALKLIKEQPQLFDEYHDGFRSQVQAWPENPVDVFVDQIRYRCMKPVNAPGGLPGLKDSKEIVIADMGCGEAQLALEINNFFKNYNKKAKKYLKRRHKVHSFDLKKANERITVADIRNVPLPDESCTIVVFCLALMGTNFLDFIKEAYRILAPRGELWIAEIKSRFSDGKGNEFVDALKLMGFFHKKTFDENKMFTRFEFFKPPAEIIEERRQKLERRQKFIEVETEKEELEKKRRKIAEGKWLLKPCIYKRR","sequence_length":392,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"72bd9179ce574f7fb1036695d406379d6f52b93ae5633559fbcfd88c0c56771c","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/P38961.json","taxon_id":"559292","uniprot_accession":"P38961","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Drosophila melanogaster","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/rrna-adenine-methyltransferase-activity-go0016433.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0016433","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/rrna-adenine-methyltransferase-activity-go0016433.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/methyltransf-8-pf05148.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF05148","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/methyltransf-8-pf05148.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/ribosomal-rna-processing-protein-8-n-terminal-domain-ipr042036.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR042036","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/ribosomal-rna-processing-protein-8-n-terminal-domain-ipr042036.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/ribosomal-rna-processing-protein-8-n-terminal-domain-1-10-10-2150.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:1.10.10.2150","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/ribosomal-rna-processing-protein-8-n-terminal-domain-1-10-10-2150.yaml"}],"pfam_ids":["PF05148"],"protein_name":"Ribosomal RNA-processing protein 8","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKPFEVPPWEEGADIIEFEPVNPSGNGVAAKKKPKKKKPKKKKAAVPNENLNVNKAAEKFTYRQGRGPLAPPQDSSDDDYEDVEDGIRAMHKVKSGRIEKQRPPTQATKGGKKELKLKPELAQAALEAMEATSSTTPAANSLASKLQSELLGGRFRYINEQLYSTTSRKAEALFRKDSSAFEAYHAGYRQQVEKWPINPLNRIIKTIKKIPKTAIIGDFGCGEGKLAQSVPNKVYSMDLVAARSDIIACNITDTPLQARTLDVAVYCLSLMGTDLNEFFLEANRVLKLHGTVYIAEIQSRFQDVREFVRCLNACGFDLNKKDVAVNYFYFFQFKKMRHVPKNTKMKAFSLKPCLYRKR","sequence_length":358,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"1755f56a15d974d255abf8c68e0f6e01d3aeaa1513019924c42bbcbb961a6d99","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q7K2B0.json","taxon_id":"7227","uniprot_accession":"Q7K2B0","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Arabidopsis thaliana","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/methyltransf-8-pf05148.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF05148","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/methyltransf-8-pf05148.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/ribosomal-rna-processing-protein-8-n-terminal-domain-ipr042036.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR042036","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/ribosomal-rna-processing-protein-8-n-terminal-domain-ipr042036.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/ribosomal-rna-processing-protein-8-n-terminal-domain-1-10-10-2150.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:1.10.10.2150","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/ribosomal-rna-processing-protein-8-n-terminal-domain-1-10-10-2150.yaml"}],"pfam_ids":["PF05148"],"protein_name":"Ribosomal RNA-processing protein 8","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTTEENKTSRNRKRKRQRNPKPSKEEPIETTPKNQNEKKNQRDTKNQQHGGSSAPSKRPKPSNFLDALRERLSGGQFRMLNEKLYTCSGKEALDYFKEDPQMFDMYHTGYQQQMSNWPELPVNSIINWLLSNSSSLVVADFGCGDARIAKSVKNKVFSFDLVSKNPSVIACDMSNTSLESSSVDVAVFCLSLMGTNYSSYIKEAHRVLRPSGMLLIAEVKSRFDPNNGGADPKDFVKAVCDLGFTSVLKDFSNKMFILFHFKKKEQMNSNQKIIKWPELKACLYKRR","sequence_length":287,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"c9e1087a3847bc1bd39af36151d551f213d2ffb50ea28c3d4b156c1828e92b37","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q84JC0.json","taxon_id":"3702","uniprot_accession":"Q84JC0","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/enosc-complex-go0061773.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0061773","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/enosc-complex-go0061773.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/regulation-of-g1-to-g0-transition-go1903450.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:1903450","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/regulation-of-g1-to-g0-transition-go1903450.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/regulation-of-transcription-by-glucose-go0046015.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0046015","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/regulation-of-transcription-by-glucose-go0046015.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/methyltransf-8-pf05148.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF05148","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/methyltransf-8-pf05148.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/ribosomal-rna-processing-protein-8-n-terminal-domain-ipr042036.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR042036","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/ribosomal-rna-processing-protein-8-n-terminal-domain-ipr042036.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/ribosomal-rna-processing-protein-8-n-terminal-domain-1-10-10-2150.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:1.10.10.2150","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/ribosomal-rna-processing-protein-8-n-terminal-domain-1-10-10-2150.yaml"}],"pfam_ids":["PF05148"],"protein_name":"Ribosomal RNA-processing protein 8","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MFEEPEWVEAAPAIVGLGAATAQVRPATAPPVKGRKRRHLLATLRALEAASLSQQTPSLPGSDSEEEEEVGRKKRHLQRPSLASVSKEVGKKRKGKCQKQAPSISDSEGKEIRRKCHRQAPPLGGVSAGEEKGKRKCQEYSSLHLTQPLDSVDQTVHNSRTSTATIDPSKPSPESMSPNSSHTLSRKQWRNRQKNKRRHKNKFRPLQTPEQAPPKASIEETEVPPVPKSDSQESRAGALRARMTQRLDGARFRYLNEQLYSGPSSAARRLFQEDPEAFLLYHRGFQRQVKKWPLHPVDRIAKDLRQKPASLVVADFGCGDCRLASSVRNPVHCFDLASLDPRVTVCDMAQVPLEDESVDVAVFCLSLMGTNIRDFLEEANRVLKTGGLLKVAEVSSRFEDIRTFLGAVTKLGFKIIYKDLTNSHFFLFDFEKTGPPRVGPKAQLSGLKLQPCLYKRR","sequence_length":457,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"e686ae1f6e61d4878b9c3652810a7049a4066d0f7ae38039b07917c5fae5c141","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9DB85.json","taxon_id":"10090","uniprot_accession":"Q9DB85","uniprot_release":"2026_03"}],"pfam_id":"PF05148","short_name":"Methyltransf_8","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}