{"cross_mech":[],"family":{"alphafold_models":8175,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family contains several actinomycete proteins. Family members such as DciA (dna[CI] antecedent) found in Pseudomonas aeruginosa, has been shown to share a common function with DnaC (in Escherichia coli) and DnaI (in Bacillus subtilis), acting as a replicative helicase. Furthermore, functional analysis revealed that DciA is essential for replication initiation and protein depletion resulted in a blockage of the initiation of replication after the formation of the open complex [[cite:PUB00085163]].","domain_architectures":11,"interpro_id":"IPR007922","known_evidence_count":null,"matches":12812,"name":"Dna[CI] antecedent, DciA","partial_evidence_count":null,"pfam_id":"PF05258","proteins":12811,"proteomes":12625,"short_name":"DciA","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05258","structures":2,"taxa":17544,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF05258.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":8175,"domain_architectures":11,"matches":12812,"proteins":12811,"proteomes":12625,"structures":2,"taxa":17544},"curation_status":"SEEDED","description":"This family contains several actinomycete proteins. Family members such as DciA (dna[CI] antecedent) found in Pseudomonas aeruginosa, has been shown to share a common function with DnaC (in Escherichia coli) and DnaI (in Bacillus subtilis), acting as a replicative helicase. Furthermore, functional analysis revealed that DciA is essential for replication initiation and protein depletion resulted in a blockage of the initiation of replication after the formation of the open complex [[cite:PUB00085163]].","id":"Pfam:PF05258","interpro_id":"InterPro:IPR007922","name":"Dna[CI] antecedent, DciA","pfam_id":"PF05258","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"DciA","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05258"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF05258.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"b3ad5c7a2cd4eda9fea8c6d1603b5211ac0cc9baf9be51e7d36a40c27d5b6018"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/dcia-pf05258.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF05258","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/dcia-pf05258.yaml"}],"pfam_ids":["PF05258"],"protein_name":"UPF0232 protein Rv0004","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTGSVDRPDQNRGERSMKSPGLDLVRRTLDEARAAARARGQDAGRGRVASVASGRVAGRRRSWSGPGPDIRDPQPLGKAARELAKKRGWSVRVAEGMVLGQWSAVVGHQIAEHARPTALNDGVLSVIAESTAWATQLRIMQAQLLAKIAAAVGNDVVRSLKITGPAAPSWRKGPRHIAGRGPRDTYG","sequence_length":187,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"fc966bde3eb556949ed1548b976ef1d39beab11a364db9eb264d3a753abcf732","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P9WFL1.json","taxon_id":"83332","uniprot_accession":"P9WFL1","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Rhodococcus jostii (strain RHA1)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/dcia-pf05258.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF05258","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/dcia-pf05258.yaml"}],"pfam_ids":["PF05258"],"protein_name":"UPF0232 protein RHA1_ro03670","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTDDLEPTAPAAAAPEPEVKGIDLARRALEEARAAAKASGKSVGQGRRSGTGVRALRARRRRGWSGPGPDDRDPQPFGALTNAIAKQRGWSPKVSEGTVLGRWVQVVGEDIAAHAEPTGLRDGILSVSAESTAWATQLRMMQSQILAKIAAAVGDGVVKSLRITGPTAPSWRKGERHIRGRGPRDTYG","sequence_length":188,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"9c9c6891d4ca665a10e16eae95e7674e2004bf0eba99b538edcef1ccdc33ed83","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q0SAG3.json","taxon_id":"101510","uniprot_accession":"Q0SAG3","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Bifidobacterium longum (strain NCC 2705)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/dcia-pf05258.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF05258","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/dcia-pf05258.yaml"}],"pfam_ids":["PF05258"],"protein_name":"UPF0232 protein BL0636","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MNPPIARQLNLDETKLPAEIFERLSRRGATLKDYRRRREEAIENFGKPGRDPAELGSVMTTIAGNGVWAANMKLAQLRNHWDQVVGQAIASHSAVADFTDGVLTIRAESTVWATQLTYLIPQLTDTIRRNLKGLTITEIRVTGPAAGYTRKWARRR","sequence_length":156,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"ff47f9b12e647095f75c9716a8f4231dd2103098dbd374c25ed6328d6f284efd","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8G6K4.json","taxon_id":"206672","uniprot_accession":"Q8G6K4","uniprot_release":"2026_03"}],"pfam_id":"PF05258","short_name":"DciA","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
