{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF05277","protein_label":"Probable lipase MIL1","reviewed":true,"short_name":"DUF726","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/clathrin-coated-vesicle-cargo-loading-go0035652.yaml","source_record_id":"GO:0035652","source_record_label":"clathrin-coated vesicle cargo loading","source_section":"canonical_examples","taxon_id":"NCBITaxon:559292","taxon_label":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","uniprot_accession":"P43564","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF05277","protein_label":"Probable lipase MIL1","reviewed":true,"short_name":"DUF726","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf726-pf05277.yaml","source_record_id":"Pfam:PF05277","source_record_label":"Protein of unknown function (DUF726)","source_section":"canonical_examples","taxon_id":"NCBITaxon:559292","taxon_label":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","uniprot_accession":"P43564","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF05277","protein_label":"Transmembrane and coiled-coil domain-containing protein STS1","reviewed":true,"short_name":"DUF726","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf726-pf05277.yaml","source_record_id":"Pfam:PF05277","source_record_label":"Protein of unknown function (DUF726)","source_section":"canonical_examples","taxon_id":"NCBITaxon:39947","taxon_label":"Oryza sativa subsp. japonica","uniprot_accession":"Q10SS2","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF05277","protein_label":"Transmembrane and coiled-coil domain-containing protein 4","reviewed":true,"short_name":"DUF726","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf726-pf05277.yaml","source_record_id":"Pfam:PF05277","source_record_label":"Protein of unknown function (DUF726)","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q5TGY1","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF05277","protein_label":"","reviewed":null,"short_name":"DUF726","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf726-pf05277.yaml","source_record_id":"Pfam:PF05277","source_record_label":"Protein of unknown function (DUF726)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":5329,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":3,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":2},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family consists of several uncharacterised eukaryotic proteins.","domain_architectures":124,"interpro_id":"IPR007941","known_evidence_count":null,"matches":7124,"name":"Protein of unknown function (DUF726)","partial_evidence_count":null,"pfam_id":"PF05277","proteins":6642,"proteomes":3362,"short_name":"DUF726","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05277","structures":0,"taxa":8425,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF05277.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":5329,"domain_architectures":124,"matches":7124,"proteins":6642,"proteomes":3362,"structures":0,"taxa":8425},"curation_status":"SEEDED","description":"This family consists of several uncharacterised eukaryotic proteins.","id":"Pfam:PF05277","interpro_id":"InterPro:IPR007941","name":"Protein of unknown function (DUF726)","pfam_id":"PF05277","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF726","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05277"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF05277.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"a5778b60e492a8a6049e0586b62240b529873687c1f40e0bbb6bb4e57ac58987"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/clathrin-coated-vesicle-cargo-loading-go0035652.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0035652","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/clathrin-coated-vesicle-cargo-loading-go0035652.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf726-pf05277.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF05277","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf726-pf05277.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:P43564","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF05277"],"protein_name":"Probable lipase MIL1","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"d63387cb5d42f42ef98daa564d9622ac65cedf1f2ba7c66b417ed6f7d8966e8b","sequence_version":2,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MSDSEEDLGVQLKGLKIARHLKESGEHTDEESNSSPEHDCGLSNQDDLTVMHTQAKEEVFKRREEDGTRTEDALHEGEAGKEGTGFPSSQSVCSPNEADSGIDRADKPILLDPFKSVHDTDPVPGTKSRSNSDSDSDSDDGGWQEMPAVSSFNIYNHRGELELTSKVRNSEQASETSPTVPPGKNCKSVNDSRFDYTKMAAEQQAQRSYRTNKKTDFLFDHKVLKKKINSSQTSVNLTSSPSTTSLNNEKNNDDDDDDSYDEYEDDVEPVNDLNRDSQLNITKNLLSDMEKFAYVGAINILANQMCTNLATLCLCIDIKSHKKLAHRLQFTQKDMAAWKTVVLSRLYDHLGISQEEIVMIEKLSLHKIQLEDLCKCLKTTQSIDNPWENDRDHEEDGIEETTERMSPNEQNGSVQASTPDPEQSATPETPKAKQSPLSSDVPGKVLDPENVKSQDKLNIDVAWTIICDLFLICLQSSTYDSRSRTLLINFAKVLNMTSLEICEFERRVTDSLDMEQSTEDQVWDEQDHMRNRRRSKRRKKMAYVALAMVGGSLVLGLSGGLLAPVIGGGIAAGLSTIGITGATSFLTGVGGTTVVAVSSTAIGANIGARGMSKRMGSVRTFEFRPLHNNRRVNLILTVSGWMVGNEDDVRLPFSTVDPVEGDLYSLYWEPEMLKSIGQTVSIVATEIFTTSLQQILGATVLTALISSIQWPMALSKLGYILDNPWNVSLDRAWSAGKILADTLIARNLGARPITLVGFSIGARVIFSCLIELCKKKALGLIENVYLFGTPAVMKKEQLVMARSVVSGRFVNGYSDKDWFLAYLFRAAAGGFSAVMGISTIENVEGIENINCTEFVDGHLNYRKSMPKLLKRIGIAVLSEEFVEIEEMMNPEEVKRKRKLINDVDAAQKKLSERKKHNSWVPKWLKPKKSKWKVMVEEAVEEGRDMQDLPENDVNNNENENPDEHEGIARQKRRDAALVDHGALMHELQLIKQAMHEDEIKNKACLPGEDKEVESSNDFLGESHYKPPSTPKINPPQSPNNFQLLSAGRTILPEDDDFDPRGKKKVEFSFPDDI","sequence_length":1073,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"d63387cb5d42f42ef98daa564d9622ac65cedf1f2ba7c66b417ed6f7d8966e8b","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/P43564.json","taxon_id":"559292","uniprot_accession":"P43564","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Oryza sativa subsp. japonica","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf726-pf05277.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF05277","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf726-pf05277.yaml"}],"pfam_ids":["PF05277"],"protein_name":"Transmembrane and coiled-coil domain-containing protein STS1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MATTLTPTQRYAAGALLALALRQAQIHQSVLLGAHHHHDDDDEEQGRTSTSSGGGGGSSSSSSNSGAGADADLWTHDSHGLLRPVFRFLEIDPKAWSGLEETAASSEAKHHIGAFLRIIFEEDGESSSDRSVQELALAKGVDVMVMSLGNDSEVGNTIKGGDQDALPSSSGTDKSPGESSHDDQLGINKLTLDDIPANNHRKMALLFALLSACVADKPVSQEEEDRKSTRFRKGYDARHRVALRLLSTWLDVKWIKMEAIEVMVACSAMAAAKEQEQSQESASPKSKWEKWKRGGIIGAAALTGGALLAITGGLAAPAIAAGFGALAPTLGTLVPVIGASGFAAMATAAGSVAGSVAVAASFGAAGAGLTGSKMARRIGSVKEFEFKPIGENHNQGRLAVGILISGFAFDEDDFCRPWEGWQDNLERYILQWESKHIIAVSTAIQDWLTSRLAMELMKQGAMRTVLSGLLAAFAWPATLLAATDFIDSKWSVAIDRSDKAGKMLAEVLLKGLQGNRPVTLIGFSLGARVIFKCLQELALSSDNEGLVERVVLLGAPVSVKGERWEAARKMVAGRFVNVYSTDDWILGVTFRASLLTQGLAGIQAIDVPGVENVDVTELVDGHSSYLSAAQQILEHLELNTYYPVFVPLSAANEETDGTVAQ","sequence_length":661,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"39874e66d1fa3c1f88df736d930d8be5e1b5b47d211b76fff951546b4ad15a7b","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q10SS2.json","taxon_id":"39947","uniprot_accession":"Q10SS2","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf726-pf05277.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF05277","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf726-pf05277.yaml"}],"pfam_ids":["PF05277"],"protein_name":"Transmembrane and coiled-coil domain-containing protein 4","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAMWNRPCQRLPQQPLVAEPTAEGEPHLPTGRELTEANRFAYAALCGISLSQLFPEPEHSSFCTEFMAGLVQWLELSEAVLPTMTAFASGLGGEGADVFVQILLKDPILKDDPTVITQDLLSFSLKDGHYDARARVLVCHMTSLLQVPLEELDVLEEMFLESLKEIKEEESEMAEASRKKKENRRKWKRYLLIGLATVGGGTVIGVTGGLAAPLVAAGAATIIGSAGAAALGSAAGIAIMTSLFGAAGAGLTGYKMKKRVGAIEEFTFLPLTEGRQLHITIAVTGWLASGKYRTFSAPWAALAHSREQYCLAWEAKYLMELGNALETILSGLANMVAQEALKYTVLSGIVAALTWPASLLSVANVIDNPWGVCLHRSAEVGKHLAHILLSRQQGRRPVTLIGFSLGARVIYFCLQEMAQEKDCQGIIEDVILLGAPVEGEAKHWEPFRKVVSGRIINGYCRGDWLLSFVYRTSSVQLRVAGLQPVLLQDRRVENVDLTSVVSGHLDYAKQMDAILKAVGIRTKPGWDEKGLLLAPGCLPSEEPRQAAAAASSGETPHQVGQTQGPISGDTSKLAMSTDPSQAQVPVGLDQSEGASLPAAASPERPPICSHGMDPNPLGCPDCACKTQGPSTGLD","sequence_length":634,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"a467dff62926f6aba0be2dbc9e29b4ff04e0ef5ea144cc64a08d2aeac12fd036","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q5TGY1.json","taxon_id":"9606","uniprot_accession":"Q5TGY1","uniprot_release":"2026_03"}],"pfam_id":"PF05277","short_name":"DUF726","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
