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This gene has been characterised in Drosophila melanogaster and named as transport and Golgi organisation 2, hence the name Tango2.","domain_architectures":86,"interpro_id":"IPR008551","known_evidence_count":null,"matches":10698,"name":"Transport and Golgi organisation 2","partial_evidence_count":null,"pfam_id":"PF05742","proteins":10332,"proteomes":8215,"short_name":"TANGO2","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05742","structures":3,"taxa":15243,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF05742.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":7660,"domain_architectures":86,"matches":10698,"proteins":10332,"proteomes":8215,"structures":3,"taxa":15243},"curation_status":"SEEDED","description":"In eukaryotes this family is predicted to play a role in protein secretion and Golgi organisation [[cite:PUB00075420]]. In plants this family includes [swissprot:A9X6Y0], which is involved in water permeability in the cuticles of fruit [[cite:PUB00075421]]. [swissprot:P54797] has been found to be expressed during early embryogenesis in mice [[cite:PUB00011316]]. This protein contains a conserved NRDE motif. This gene has been characterised in Drosophila melanogaster and named as transport and Golgi organisation 2, hence the name Tango2.","id":"Pfam:PF05742","interpro_id":"InterPro:IPR008551","name":"Transport and Golgi organisation 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